Mansour, Nadine M. Balas, E. Andrew Yang, Frances M. Vernon, Marlo M.
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Studies have found that many published life sciences research results are irreproducible. Our goal was to provide comprehensive risk estimates of familiar reproducibility deficiencies to support quality improvement in research. Material/Methods Reports included were peer-reviewed, published between 1980 and 2016, and presented frequency ...
Sounderajah, V Ashrafian, H Aggarwal, R De Fauw, J Denniston, AK Greaves, F Karthikesalingam, A King, D Liu, X Markar, SR
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Villca Villegas, Jose Luis Moreno Choque, Rocio Aracely
En Bolivia, la investigación está poco estandarizada1-3, empezando por la pregunta de investigación que se ve reflejada en lo descrito en los objetivos de investigación que los autores reportan en sus manuscritos científicos4 , en artículos originales o artículos de revisión , que son los dos tipos de artículos que deben reportar su objetivo genera...
Recchia, Gabriel Chiappi, Antonia Chandratillake, Gemma Raymond, Lucy Freeman, Alex
PURPOSE Guidelines recommend that genetic reports should be clear to nonspecialists, including patients. We investigated the feasibility of creating reports for cystic fibrosis carrier testing through a rapid user-centered design process that built on a previously developed generic template. We evaluated the new reports’ communication efficacy and ...
Hamilton, Samina Bernstein, Aaron B. Blakey, Graham Fagan, Vivien Farrow, Tracy Jordan, Debbie Seiler, Walther Gertel, Art
Published in
Research Integrity and Peer Review
BackgroundCORE (Clarity and Openness in Reporting: E3-based) Reference (released May 2016 by the European Medical Writers Association [EMWA] and the American Medical Writers Association [AMWA]) is a complete and authoritative open-access user’s guide to support the authoring of clinical study reports (CSRs) for current industry-standard-design inte...
Tshitoyan, Vahe Dagdelen, John Weston, Leigh Dunn, Alexander Rong, Ziqin Kononova, Olga Persson, Kristin A Ceder, Gerbrand Jain, Anubhav
The overwhelming majority of scientific knowledge is published as text, which is difficult to analyse by either traditional statistical analysis or modern machine learning methods. By contrast, the main source of machine-interpretable data for the materials research community has come from structured property databases1,2, which encompass only a sm...
Gendre, Delphine Baral, Anirban Dang, Xie Esnay, Nicolas Boutté, Yohann Stanislas, Thomas Vain, Thomas Claverol, Stéphane Gustavsson, Anna Lin, Deshu
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Root hairs are protrusions from root epidermal cells with crucial roles in plant soil interactions. Although much is known about patterning, polarity and tip growth of root hairs, contributions of membrane trafficking to hair initiation remain poorly understood. Here, we demonstrate that the trans-Golgi network-localized YPT-INTERACTING PROTEIN 4a ...
Gamir-Morralla, Andrea Sacristán, Sandra Medina, Miguel Iglesias, Teresa
The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism to study lifespan and aging, protein aggregation, and neurodegeneration, as well as to carry out drug screenings. The C. elegans strain aex-3/T337 expresses human pathogenic V337M mutant tau under a pan-neuronal promoter and presents uncoordinated locomotion, accumulation...
Bardakjian, Tanya M. Naczi, Kaylee Faulkner Gonzalez-Alegre, Pedro
BACKGROUND: Advances in molecular therapeutic approaches in the last decade are translating into the design of non-traditional clinical trials. In order to improve their feasibility, it is important to understand the attitudes of potential participants towards these trials, their motivations to get involved and acceptance of risks. OBJECTIVE: We ai...
Tousley, Adelaide Iuliano, Maria Weisman, Elizabeth Sapp, Ellen Zhang, Ningzhe Vodicka, Petr Alexander, Jonathan Aviolat, Hubert Gatune, Leah Reeves, Patrick
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BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington’s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTPase Rac1 is a downstream target of growth factor s...
