Hamilton, Samina Bernstein, Aaron B. Blakey, Graham Fagan, Vivien Farrow, Tracy Jordan, Debbie Seiler, Walther Gertel, Art
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Research Integrity and Peer Review
BackgroundCORE (Clarity and Openness in Reporting: E3-based) Reference (released May 2016 by the European Medical Writers Association [EMWA] and the American Medical Writers Association [AMWA]) is a complete and authoritative open-access user’s guide to support the authoring of clinical study reports (CSRs) for current industry-standard-design inte...
Tshitoyan, Vahe Dagdelen, John Weston, Leigh Dunn, Alexander Rong, Ziqin Kononova, Olga Persson, Kristin A Ceder, Gerbrand Jain, Anubhav
The overwhelming majority of scientific knowledge is published as text, which is difficult to analyse by either traditional statistical analysis or modern machine learning methods. By contrast, the main source of machine-interpretable data for the materials research community has come from structured property databases1,2, which encompass only a sm...
Gendre, Delphine Baral, Anirban Dang, Xie Esnay, Nicolas Boutté, Yohann Stanislas, Thomas Vain, Thomas Claverol, Stéphane Gustavsson, Anna Lin, Deshu
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Root hairs are protrusions from root epidermal cells with crucial roles in plant soil interactions. Although much is known about patterning, polarity and tip growth of root hairs, contributions of membrane trafficking to hair initiation remain poorly understood. Here, we demonstrate that the trans-Golgi network-localized YPT-INTERACTING PROTEIN 4a ...
Gamir-Morralla, Andrea Sacristán, Sandra Medina, Miguel Iglesias, Teresa
The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism to study lifespan and aging, protein aggregation, and neurodegeneration, as well as to carry out drug screenings. The C. elegans strain aex-3/T337 expresses human pathogenic V337M mutant tau under a pan-neuronal promoter and presents uncoordinated locomotion, accumulation...
Bardakjian, Tanya M. Naczi, Kaylee Faulkner Gonzalez-Alegre, Pedro
BACKGROUND: Advances in molecular therapeutic approaches in the last decade are translating into the design of non-traditional clinical trials. In order to improve their feasibility, it is important to understand the attitudes of potential participants towards these trials, their motivations to get involved and acceptance of risks. OBJECTIVE: We ai...
Tousley, Adelaide Iuliano, Maria Weisman, Elizabeth Sapp, Ellen Zhang, Ningzhe Vodicka, Petr Alexander, Jonathan Aviolat, Hubert Gatune, Leah Reeves, Patrick
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BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington’s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTPase Rac1 is a downstream target of growth factor s...
Younce, John R. Davis, Albert A. Black, Kevin J.
The atypical antipsychotic ziprasidone has been considered inappropriate for use in patients with Parkinson’s disease (PD), as most atypical antipsychotics worsen parkinsonism. However, the current evidence for safety and efficacy of ziprasidone in PDP has not been evaluated in a systematic fashion. We review published experience with ziprasidone f...
Semrad, Thomas J Groshen, Susan Luo, Chunqiao Pal, Sumanta Vaishampayan, Ulka Joshi, Monika Quinn, David I. Mack, Philip C. Gandara, David R. Lara, Primo N.
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BACKGROUND: In renal cell carcinoma (RCC), angiopoietin (Ang) 2 is elevated at the time of progression on anti-vascular endothelial growth factor (VEGF) therapy and may contribute to resistance. OBJECTIVE: We tested trebananib, an Ang 1 and 2 neutralizing peptibody in patients with RCC progressing on anti-VEGF treatment. METHODS: Patients with meas...
Santiago, Anthony Langston, James W. Gandhy, Rita Dhall, Rohit Brillman, Salima Rees, Linda Barlow, Carrolee
BACKGROUND: Wearable sensors provide accurate, continuous objective measurements, quantifying the variable motor states of patients with Parkinson’s disease (PD) in real time. OBJECTIVES: To evaluate the impact of using continuous objective measurement using the Personal KinetiGraph™ (PKG(®)) Movement Recording System in the routine clinical care o...
Bohush, Anastasiia Niewiadomska, Grażyna Weis, Serge Filipek, Anna
BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the presence of inclusions known as Lewy bodies in some brain regions. Lewy bodies consist of α-synuclein and many other proteins including chaperones. OBJECTIVE: To learn more about the role of chaperone complexes in PD and a related disorder, i.e., dementia with...
