Zhang, Yan Zou, Dongmei Yin, Jingjing Zhang, Li Zhang, Xiao Wang, Wei Zhang, Meifen Zhou, Daobin Zhang, Wei
Published in
BMC Cancer
Backgroud Establishing diagnostic and prognostic biomarkers of primary central nervous system lymphoma (PCNSL) is a challenge. This study evaluated the value of dynamic interleukin (IL)-10 cerebrospinal fluid (CSF) concentrations for prognosis and relapse prediction in PCNSL. Methods Consecutive 40 patients newly diagnosed with PCNSL between April ...
Enya, Takuji Morimoto, Yuichi Oshima, Rina Miyazaki, Kohei Miyazawa, Tomoki Okada, Mitsuru Sugimoto, Keisuke
Published in
CEN Case Reports
Clinical data on coronavirus disease-19 (COVID-19) in children during the management of nephrotic syndrome (NS) is lacking. Patients on prednisolone are compromised hosts at the risk of severe infections. Some infections may induce NS relapse. We describe the clinical course of a child with NS and COVID-19. A 3-year-old boy was admitted with clinic...
Christian, Martin T. Maxted, Andrew P.
Published in
Pediatric Nephrology (Berlin, Germany)
The use of corticosteroids in the treatment of steroid-sensitive nephrotic (SSNS) syndrome in children has evolved surprisingly slowly since the ISKDC consensus over 50 years ago. From a move towards longer courses of corticosteroid to treat the first episode in the 1990s and 2000s, more recent large, well-designed randomized controlled trials (RCT...
Rahn, Anne Christin Wenzel, Lisa Icks, Andrea Stahmann, Alexander Scheiderbauer, Jutta Grentzenberg, Kristina Vomhof, Markus Montalbo, Joseph Friede, Tim Heesen, Christoph
...
Published in
Trials
Introduction Multiple sclerosis is a chronic inflammatory, degenerative disease of the central nervous system manifesting at first with relapses in about 85% of cases. In Germany, intravenous therapy with high-dose corticosteroids is the treatment standard of acute relapses. The treatment leads to a faster reduction of symptoms in about 25 of 100 t...
Delgado, Silvia Hernandez, Jeffrey Tornes, Leticia Rammohan, Kottil
Published in
BMC Neurology
BackgroundFingolimod is a S1P1 receptor modulator that prevents activated lymphocyte egress from lymphoid tissues causing lymphopenia, mainly affecting CD4+ T lymphocytes. Withdrawal from fingolimod can be followed by severe disease reactivation, and this coincides with return of autoreactive lymphocytes into circulation. The CD8+ T cytotoxic popul...
Kabisa, Eric Biracyaza, Emmanuel Habagusenga, Jean d’Amour Umubyeyi, Aline
Published in
Substance Abuse Treatment, Prevention, and Policy
BackgroundRelapse to substance use after successful detoxication and rehabilitation is a public health concern worldwide. Forty to sixty percent of persons in general relapsed after completing detoxication and rehabilitation treatments. Although substance use remains a burden in Rwanda, very little is known about relapse among people with substance...
Jenkins, Garrett James Cleveland, Michael J Knapp, Kyler Scott Bunce, Scott C Cleveland, H Harrington
Published in
Addictive behaviors
Opioid use disorders are chronic and relapse is common. Both negative affect and craving have been suggested antecedents of relapse and have been shown to demonstrate within- and between-person variability, as well as association with each other. The present study extends previous research by examining the covariation of negative affect and craving...
Kimura, Hiroshi Kanahara, Nobuhisa Iyo, Masaomi
Published in
Behavioural brain research
The long-term treatment of patients with schizophrenia often involves the management of relapses for most patients and the development of treatment resistance in some patients. To stabilize the clinical course and allow as many patients as possible to recover, clinicians need to recognize dopamine supersensitivity, which can be provoked by administ...
Levin, May Stark, Michal Ofran, Yishai Assaraf, Yehuda G.
Published in
Cancer Cell International
BackgroundAcute myeloid leukemia (AML) remains a devastating disease with a 5-year survival rate of less than 30%. AML treatment has undergone significant changes in recent years, incorporating novel targeted therapies along with improvements in allogeneic bone marrow transplantation techniques. However, the standard of care remains cytarabine and ...
Caravedo, Maria A. Kaura, Abhimanyu Reynoso, David
Published in
IDCases
In developing countries, typhoid fever is a common cause of febrile illness accompanied by abdominal pain and weakness. It is caused by Salmonella enterica serovar Typhi. Humans are the only known reservoir of infection, and typhoid fever is common in regions where access to clean water and sanitation is limited. The antimicrobials of choice for a ...
