Klaus, Kristel Vaht, Mariliis Pennington, Kyla Harro, Jaanus
Previous research has shown that dopaminergic dysregulation and early life stress interact to impact on aspects of impulse control. This study aimed to explore the potentially interactive effects of the rs6277 polymorphism of the dopamine D2 receptor gene (DRD2), stressful or supportive environment and sex on behavioural and self-reported measures ...
Zhang, Rou Ma, Wen-Qi Fu, Meng-Jun Li, Juan Hu, Chun-Hua Chen, Yi Zhou, Mi-Mi Gao, Zhi-Jie He, Ying-Li
Published in
World Journal of Clinical Cases
Bile acids (BAs) are classically known to play a vital role in the metabolism of lipids and in absorption. It is now well established that BAs act as signaling molecules, activating different receptors (such as farnesoid X receptor, vitamin D receptor, Takeda G-protein-coupled receptor 5, sphingosine-1-phosphate, muscarinic receptors, and big potas...
Verkhratsky, Alexei Sun, Dandan Tanaka, Junya
Published in
Neurochemistry international
Microglia as a defensive arm of the nervous system emerged early in evolution. The surveilling microglia with motile and ramified processes are the main phenotype in the healthy CNS; the surveilling microglial patrol neuronal somata, dendrites, dendritic spines and axons. Increasing evidence suggests that microglia play fundamental roles in develop...
Kim, Jung-Hwan Matsubara, Tsutomu Lee, Jaekwon Fenollar-Ferrer, Cristina Han, Kyungreem Kim, Donghwan Jia, Shang Chang, Christopher J Yang, Heejung Nagano, Tomokazu
...
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function. SL...
Klaus, K Vaht, M Pennington, K Harro, J
Published in
Behavioural brain research
Previous research has shown that dopaminergic dysregulation and early life stress interact to impact on aspects of impulse control. This study aimed to explore the potentially interactive effects of the rs6277 polymorphism of the dopamine D2 receptor gene (DRD2), stressful or supportive environment and sex on behavioural and self-reported measures ...
Azizi, Michel
Blocking the mineralocorticoid receptor (MR) is one of the most effective ways of reducing blood pressure in patients with resistant hypertension and improving cardiovascular prognosis in patients with heart failure with reduced ejection fraction and left ventricular dysfunction after myocardial infarction. Blockade of the biological effects of ald...
Gao, Yuan Zhang, Hang Lirussi, Frédéric Garrido, Carmen Ye, Xiang-Yang Xie, Tian
Published in
Biochemical pharmacology
Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug targets which have been studied intensively in the past few decades. Although several drugs have been approved in this field, they are still limited to a subset of hematological malignancies (in particular T-cell lymphomas), with therapeutic potential not fully...
Sinha, Pratik Calfee, Carolyn S Cherian, Shiney Brealey, David Cutler, Sean King, Charles Killick, Charlotte Richards, Owen Cheema, Yusuf Bailey, Catherine
...
BackgroundIn acute respiratory distress syndrome (ARDS) unrelated to COVID-19, two phenotypes, based on the severity of systemic inflammation (hyperinflammatory and hypoinflammatory), have been described. The hyperinflammatory phenotype is known to be associated with increased multiorgan failure and mortality. In this study, we aimed to identify th...
Samuel, Ryan M Majd, Homa Richter, Mikayla N Ghazizadeh, Zaniar Zekavat, Seyedeh Maryam Navickas, Albertas Ramirez, Jonathan T Asgharian, Hosseinali Simoneau, Camille R Bonser, Luke R
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SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the disease and potential treatment options remains limited. The infection occurs through binding of the virus with angiotensin converting enzyme 2 (ACE2) on the cell membrane. Here, we established a screening strategy to identify drugs that reduce ACE2 levels in h...
Bakare, Olalekan Olanrewaju Keyster, Marshall Pretorius, Ashley
Published in
BMC Molecular and Cell Biology
BackgroundPneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A few biomarkers, which up to this point have been distinguished for its determination lack specificity, as these biomarkers fail to bu...