Messmer, Sarah J Salmeron, Kathleen E Frank, Jacqueline A McLouth, Christopher J Lukins, Douglas E Hammond, Tyler C Lin, Ai-Ling Fraser, Justin F Pennypacker, Keith R
Published in
Translational stroke research
Stroke remains a leading global cause of death and disability. In the last decade, the therapeutic window for mechanical thrombectomy has increased from a maximum of 6 to 24 h and beyond. While endovascular advancements have improved rates of recanalization, no post-stroke pharmacotherapeutics have been effective in enhancing neurorepair and recove...
Zhao, Chunfang Han, Yujiao Wang, Chenfang Ren, Man Hu, Qianqian Gu, Youfang Ye, Pengfei Li, Shenghe Jin, Erhui
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Biological trace element research
As an essential trace element, appropriate boron supplementation can promote immune function of animals. To illustrate the effects of boron in a rat model, RNA-Seq was conducted for the RNA from duodenum after treatment with different concentration of boron in which boron was given in the form of boric acid. More than 47 million reads were obtained...
Bonnin, Philippe Kubis, Nathalie Charriaut-Marlangue, Christiane
Published in
Translational stroke research
Enhancing the collateral blood supply during the acute phase of cerebral ischemia may limit both the extension of the core infarct, by rescuing the penumbra area, and the degree of disability. Many imaging techniques have been applied to rodents in preclinical studies, to evaluate the magnitude of collateral blood flow and the time course of respon...
Deibel, Scott H Lewis, Leanna M Cleary, Jillian Cassell, Taylor T S Skinner, Darlene M Thorpe, Christina M
Published in
Behavioural processes
Some degree of circadian rhythm disruption is hard to avoid in today's society. Along, with many other deleterious effects, circadian rhythm disruption impairs memory. One way to study this is to expose rats to daylengths that are outside the range of entrainment. As a result, circadian processes and behaviours occur during phases of the light dark...
Kalati, Zinat Heydarnia Gholami, Omid Amin, Bahareh Pejhan, Akbar Sahab-Negah, Sajad Gholami, Masoumeh Azhdari-Zarmehri, Hassan Mohammad-Zadeh, Mohammad
Published in
Neurochemical research
Dentate gyrus (DG) has a high density of 5-HT1A receptors. It has neural nitric oxide synthase (nNOS), which is involved in neural excitability. The purpose of this study was to investigate the role of 5-HT1A receptors and nNOS of DG in perforant path kindling model of epilepsy. To achieve this purpose, a receptor antagonist (WAY100635, 0.1 mg/kg, ...
Park, Sung-Hyeuk Lim, Je-Oh Kim, Woong-Il Park, So-Won Lee, Se-Jin Shin, In-Sik Moon, Changjong Kim, Je-Hein Heo, Jeong-Doo Kim, Jong-Choon
...
Published in
Biological trace element research
Several studies on the potential adverse effects of aluminum oxide nanoparticles (Al2O3NPs) have reported conflicting results. The present study investigated the potential adverse effects of Al2O3NPs in Sprague-Dawley rats following 28-day repeated oral administration. In addition, we aimed to determine the target organ and no-observed-adverse-effe...
Song, Xiaopeng Zhao, Mingchao Tang, Jilang Ma, Tianwen Bai, Hui Wang, Xinyu Liu, Lin Li, Ting Xu, Xinyu Sheng, Xuanbo
...
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Arthritis research & therapy
Light alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate osteoarthritis (OA). Therefore, the aim of this study was to evaluate the effects of continuous dark-light (DL) cycle on joint inflammation, bone structure, and metabo...
Korgan, Austin C. Foxx, Christine L. Hashmi, Heraa Sago, Saydie A. Stamper, Christopher E. Heinze, Jared D. O’Leary, Elizabeth King, Jillian L. Perrot, Tara S. Lowry, Christopher A.
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Published in
Scientific Reports
Exposing a male rat to an obesogenic high-fat diet (HFD) influences attractiveness to potential female mates, the subsequent interaction of female mates with infant offspring, and the development of stress-related behavioral and neural responses in offspring. To examine the stomach and fecal microbiome’s potential roles, fecal samples from 44 offsp...
Antonello, Priscila C Varley, Thomas F Beggs, John Porcionatto, Marimélia Sporns, Olaf Faber, Jean
Published in
eLife
Activity-dependent self-organization plays an important role in the formation of specific and stereotyped connectivity patterns in neural circuits. By combining neuronal cultures, and tools with approaches from network neuroscience and information theory, we can study how complex network topology emerges from local neuronal interactions. We constru...
Fahmy, Heba M Mohamed, Eman R Hussein, Aida A Khadrawy, Yasser A Ahmed, Nawal A
Published in
BMC pharmacology & toxicology
The current study evaluates the free gallic acid (GA) and GA-loaded mesoporous silica nanoparticles (MSNs) antidepressant efficacy in a rat model of depression caused by reserpine. By using a scanning electron microscope (SEM), dynamic light scattering (DLS), and zeta potential, MSNs and GA-loaded MSNs were characterized. The efficiency of encapsul...
