Colín, Elizabeth Ramírez-Jarquín, Uri Nimrod Tapia, Ricardo
Published in
Neuroscience letters
Motor behavior alterations are a shared hallmark of neurodegenerative diseases affecting motor circuits, such as amyotrophic lateral sclerosis (ALS), Parkinson's, and Huntington's diseases. In patients and transgenic animal models of amyotrophic lateral sclerosis fine movements controlled by distal muscles are the first to be affected, but its stud...
Pitsikas, Nikolaos Carli, Mirjana
Published in
Neuroscience letters
Ketamine, a non-competitive NMDA receptor antagonist, has been reported to mimic the cognitive symptoms of schizophrenia in animals. It has been reported to produce learning and memory deficits in rodents. However, there have limited number of reports that investigated the specific components of memory process that are affected with ketamine. In th...
Nozari, Elham Moradi, Ali Samadi, Morteza
Published in
Life sciences
Liver fibrosis is an inflammatory and fibrogenic process that occurs following chronic liver damage. TGFβ1 is the key inducer of fibrosis. MiR-21 and miR-122 are two miRNAs that their expression changes during fibrosis. In the present study, we investigate the effects of curcumin, quercetin, and atorvastatin on the expression levels of miR-21 and m...
Dolenec, Petra Pilipović, Kristina Janković, Tamara Župan, Gordana
Published in
Journal of neuropathology and experimental neurology
We examined damage and repair processes in the rat cerebellum within the first week following moderate traumatic brain injury (TBI) induced by lateral fluid percussion injury (LFPI) over the left parietal cortex. Rats were killed 1, 3, or 7 days after the injury or sham procedure. Fluoro-Jade B staining revealed 2 phases of neurodegenerative change...
Laue, Heike Badertscher, Remo P Hostettler, Lu Weiner-Sekiya, Yumiko Haupt, Tina Nordone, Adrian Adamson, Gregory M Natsch, Andreas
Published in
Archives of toxicology
A number of para-substituted benzoic acids (p-BA) and chemicals metabolized to p-BA have been found to confer adverse effects in male rats on sperm viability, motility, and morphology. These effects are putatively associated with the metabolism of p-BA to toxic intermediates. We had shown that p-BA lead to accumulation of high levels of p-alkyl-ben...
Elsedawi, Basma Fathi Hussein, Youssef Sabry, Mohamed Ahmed Aziz, Joseph Amin
Published in
Anatomical science international
Fluoxetine (FLX) is extensively used for the treatment of a diversity of psychiatric disorders, mainly depression. However, it can adversely affect male fertility. This study was done to clarify the changes which take place in the testes after the oral administration of FLX and to evaluate the possible preventative role of curcumin. Seventy-six adu...
Sivas, Mustafa Can Tapisiz, Omer Lutfi Ayik, Rasit Tan Kahraman, Devrim Kiykac Altinbas, Sadiman Moraloglu Tekin, Ozlem
Published in
Heliyon
Physiology; Surgery; Women's health; Gynecology; Reproductive system; Endocrinology; Uterine hypertrophy; Endometrial hyperplasia; Melatonin; Rat; Estradiol.
González, Pau González-Fernández, Carlos Campos-Martín, Yolanda Mollejo, Manuela Carballosa-Gautam, Melissa Marcillo, Alexander Norenberg, Michael García-Ovejero, Daniel Rodríguez, Francisco Javier
Published in
Cellular and molecular neurobiology
Despite the emerging role of protein tyrosine kinase 7 (PTK7) as a Wnt co-receptor and the relevant functions of the Wnt family of proteins in spinal cord injury (SCI), the potential involvement of PTK7 in SCI is currently unknown. As a first essential step to shed light on this issue, we evaluated the spatio-temporal and cellular expression patter...
Taylor, Rachel M Jeong, Isaac H May, Matthew D Bergman, Elizabeth M Capaldi, Vincent F Moore, Nicole L T Matson, Liana M Lowery-Gionta, Emily G
Published in
Psychopharmacology
Evaluation of pharmacotherapies for acute stress disorder (ASD) or post-traumatic stress disorder (PTSD) is challenging due to robust heterogeneity of trauma histories and limited efficacy of any single candidate to reduce all stress-induced effects. Pursuing novel mechanisms, such as the nociceptin/orphanin FQ (NOP) system, may be a viable path fo...
Kaya-Yertutanol, Fatma Duygu Uzbay, İ Tayfun Çevreli, Burcu Bolay-Belen, Hayrunnisa
Published in
Psychopharmacology
There are controversial reports on the effects of gabapentin in respect to psychotic symptoms. Prepulse inhibition of the acoustic startle response is an operational measure of sensorimotor gating. In laboratory rodents, deficits in sensorimotor gating are used to model behavioral endophenotypes of schizophrenia. Sleep deprivation disrupts prepulse...
