Rosenblatt, Amir Hekselman, Igal Rosenblatt, Irit Hekselman, Idan Gaton, Dan
Published in
Israel Journal of Health Policy Research
BackgroundHigh and increasing drug prices have prompted the establishment of a broad range of cost-containment treatment policies in health systems globally. In 2012, the supplemental insurance program of a large Israeli health maintenance organization (Clalit Health Services) introduced a prior authorization process for second-line use of ranibizu...
Oshima, Yuji Ishibashi, Yumi Umeda, Naoyasu Nagata, Tatsuo Yoshida, Shigeo Uchio, Eiichi Kondo, Hiroyuki Sonoda, Koh-hei Ishibashi, Tatsuro
Published in
BMC Ophthalmology
BackgroundTo evaluate the correlation between visual acuity improvement and vision-related QOL after ranibizumab treatment in Japanese patients with AMD.MethodsIn this one-year prospective, interventional, open-label, multicenter study involving four sites, patients with neovascular AMD were enrolled and observed for 12 months. Treatment-naïve pati...
Narayanan, Raja Kelkar, Aditya Abbas, Zahir Goel, Neha Soman, Manoj Naik, Naveen Sudhalkar, Aditya Walinjkar, Jaydeep Shah, Utkarsh Maksane, Nitin
...
Published in
BMC Ophthalmology
BackgroundMacular edema secondary to retinal vein occlusion (RVO) is an important cause of loss of vision. Intravitreal injections (IVI) of anti-vascular endothelial growth factor (VEGF) are the standard of care in this disease, as shown in numerous randomized controlled trials. The purpose of this study was to study the efficacy and safety of rani...
Li, Jun Zhang, Rui Gu, Feng Liu, Zhe-Li Sun, Peng
Published in
World Journal of Clinical Cases
BACKGROUND Waldenström macroglobulinemia (WM) is a distinct clinicopathologic entity characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M (IgM) in the blood, and patients may present with symptoms related to the infiltration of the hematopoietic tissues or the effects of mon...
Abdelrahman, Amr Massoud, Wagiha Elshafei, Ahmed Mohamed Kamal Genidy, Mahmoud Abdallah, Raafat Mohyeldeen Abdelrahman
Published in
International Journal of Retina and Vitreous
BackgroundTo compare the therapeutic effects of subthreshold micropulse laser (SML) versus intravitreal injection of ranibizumab in treatment of diabetic macular edema (DME) both anatomically using optical coherence tomography (OCT) and functionally using best corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG).Methodshis study ...
Wu, Wen-Chuan Chen, Jiann-Torng Tsai, Ching-Yao Wu, Chien-Liang Cheng, Cheng-Kuo Shen, Yun-Dun Tsai, Arslan Wu, Pei-Chang
Published in
BMC Ophthalmology
BackgroundThe current National Health Insurance scheme in Taiwan reimburses 3 initial plus 4 additional injections of ranibizumab 0.5 mg for eligible patients with neovascular age-related macular degeneration (nAMD). The Ranibizumab AMD Clinical Efficacy in Real-world practice (RACER) study aimed to observe the effectiveness of ranibizumab injectio...
Wang, Zonghua Liu, Anqi Zhang, Han Wang, Ming Tang, Qiao Huang, Yifei Wang, Liqiang
Published in
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Previously, we have demonstrated the use of lipidoid (lipid-like) nanoparticles (e.g., "1-O16B") for gene delivery to live cells, as an alternative to viral vectors. Here, we encapsulate VEGF siRNA (siVEGF) in bioreducible lipidoid nanoparticles and examine whether these nanocomplexes can reduce intravitreal neovascularization in a rodent model of ...
Chen, Kailin Xu, Wen Zheng, Jiao Shen, Yupeng Ma, Jian Chen, Zhiqing
Published in
BMC Ophthalmology
BackgroundNumerous cytokines have been proven to participate in the pathogenesis of neovascular age-related macular degeneration (nAMD). The present study aimed to investigate the aqueous humor cytokine expression profile in nAMD patients before and after ranibizumab treatments in comparison to cataract patients.MethodsThis prospective study includ...
Falcão, Manuel
Published in
Kompass Ophthalmologie
Purpose: Evaluation of the impact of the injection frequency of ranibizumab on best-corrected visual acuity (BCVA) outcomes in patients with diabetic macular edema (DME). Methods: A meta-analysis of randomized controlled trials (RCTs) and real-world studies was performed to quantify the effect of ranibizumab treatment on BCVA and central foveal thi...
Feltgen, Nicolas
Published in
Kompass Ophthalmologie
Purpose: The aim of this study was to evaluate the 9-year outcome of ranibizumab monotherapy for myopic choroidal neovascularization (mCNV). Methods: This was a retrospective, nonrandomized, multicentric study to evaluate the long-term outcomes of mCNV treated with ranibizumab monotherapy for at least 9 years according to a strict pro re nata regim...
