Galante, Julieta Friedrich, Claire Dalgleish, Tim White, Ian R Jones, Peter B
Introduction
With mental ill health listed as a top cause of global disease burden, there is an urgent need to prioritise mental health promotion programmes. Mindfulness-based programmes (MBPs) are being widely implemented to reduce stress in non-clinical settings. In a recent aggregate-level meta-analysis we found that, compared with no interventio...
Ponsford, Ruth Meiksin, Rebecca Allen, Elizabeth Melendez-Torres, G J Morris, Steve Mercer, Catherine Campbell, Rona Young, Honor Lohan, Maria Coyle, Karin
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Background
Positive Choices is a whole-school social-marketing intervention to promote sexual health among secondary school students. Intervention comprises the following: school health promotion council involving staff and students coordinating delivery, student survey to inform local tailoring, teacher-delivered classroom curriculum, student-run c...
Lee, Tara T M Collett, Corinne Man, Mei-See Hammond, Matt Shepstone, Lee Hartnell, Sara Gurnell, Eleanor Byrne, Caroline Scott, Eleanor M Lindsay, Robert S
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Background
Pregnant women with type 1 diabetes strive for tight glucose targets (3.5-7.8 mmol/L) to minimise the risks of obstetric and neonatal complications. Despite using diabetes technologies including continuous glucose monitoring (CGM), insulin pumps and contemporary insulin analogues, most women struggle to achieve and maintain the recommende...
Bennett, Marc P Knight, Rachel Dunning, Darren Archer-Boyd, Alan Blakemore, Sarah-Jayne Dalmaijer, Edwin Ford, Tamsin Jane Williams, J Mark G Clegg, Hannah Kuyken, Willem
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INTRODUCTION: Decentering describes the ability to voluntarily adopt an objective self-perspective from which to notice internal, typically distressing, stressors (eg, difficult thoughts, memories and feelings). The reinforcement of this skill may be an active ingredient through which different psychological interventions accrue reductions in anxie...
Earwaker, Melissa Villar, Sofia Fox-Rushby, Julia Duckworth, Melissa Dawson, Sarah Steele, Jo Chiu, Yi-da Litton, Edward Kunst, Gudrun Murphy, Gavin
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BACKGROUND: High-flow nasal therapy is a non-invasive form of respiratory support that delivers low-level, flow dependent positive airway pressure. The device can be better tolerated by patients than alternatives such as continuous positive airway pressure. The primary objective is to determine if prophylactic high-flow nasal therapy after tracheal...
Smith, Patrick Ehlers, Anke Carr, Ewan Clark, David Dalgleish, Tim Forbes, Gordon Goldsmith, Kimberley Griffiths, Helena Gupta, Monica King, Dorothy
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Introduction
Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition that affects a significant minority of young people exposed to traumatic events. Effective face-to-face psychological treatments for PTSD exist. However, most young people with PTSD do not receive evidence-based treatment. Remotely delivered digital interventions...
Pellino, Gianluca Fuschillo, Giacomo Simillis, Costantinos Selvaggi, Lucio Signoriello, Giuseppe Vinci, Danilo Kontovounisios, Christos Selvaggi, Francesco Sciaudone, Guido
BACKGROUND: External rectal prolapse (ERP) is a debilitating condition in which surgery plays an important role. The aim of this study was to evaluate the outcomes of abdominal approaches (AA) and perineal approaches (PA) to ERP. METHODS: This was a PRISMA-compliant systematic review with meta-analysis. Studies published between 1990 and 2021 were ...
Lee, MJ Collins, S Babalis, D Johnson, N Falaschetti, E Prevost, AT Ashraf, A Jacob, M Cole, T Hurley, L
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Background: Antiretroviral therapy (ART) has led to dramatic improvements in survival for people living with HIV, but is unable to cure infection, or induce viral control off therapy. Designing intervention trials with novel agents with the potential to confer a period of HIV remission without ART remains a key scientific and community goal. We det...
Long, Yu-Qin Feng, Xiao-Mei Shan, Xi-Sheng Chen, Qing-Cai Xia, Zhengyuan Ji, Fu-Hai Liu, Hong Peng, Ke
BackgroundResults from previous studies evaluating the effects of remote ischemic preconditioning (RIPC) on morbidity and mortality after cardiac surgery are inconsistent. This meta-analysis of randomized controlled trials (RCTs) aims to determine whether RIPC improves cardiac and renal outcomes in adults undergoing cardiac surgery.MethodsPubMed, E...
Aapkes, SE; Bernts, LHP; van den Berg, AP; van den Berg, M; Blokzijl, H; Cantineau, AEP; van Gastel, MDA; de Haas, RJ; Kappert, P; Muller, RU;
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BACKGROUND: In patients with severe polycystic liver disease (PLD), there is a need for new treatments. Estrogens and possibly other female sex hormones stimulate growth in PLD. In some patients, liver volume decreases after menopause. Female sex hormones could therefore be a target for therapy. The AGAINST-PLD study will examine the efficacy of th...