Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients - mulTi-Arm Therapeutic study in pre-ICu patients adm...
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ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in fro...
The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for repor...
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Adaptive designs (ADs) allow pre-planned changes to an ongoing trial without compromising the validity of conclusions and it is essential to distinguish pre-planned from unplanned changes that may also occur. The reporting of ADs in randomised trials is inconsistent and needs improving. Incompletely reported AD randomised trials are difficult to re...
Transcatheter aortic valve implantation versus surgical aortic valve replacement for treatment of severe aortic stenosis...
Abstract Objective: Results from randomized controlled trials (RCTs) and real-world study (RWS) appear to be discordant. We aimed to investigate whether data derived from RCTs and RWS evaluating long-term all-cause mortality of transcatheter aortic valve implantation (TAVI) versus surgical aortic valve replacement (SAVR) in patients with severe aor...
Review of precision cancer medicine: Evolution of the treatment paradigm.
In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify these characteristics for optimization of anticancer therapy in individual patients. Consequently, c...
The challenge of early detection in cancer.
P. D. P. P. receives salary support from the National Health Service (NHS) in the East of England through the Clinical Academic Reserve. / Multiple developments in imaging and biomarkers have shown promise as tests for the earlier detection of cancer, but a prerequisite for their success in reducing death from cancer is taking into account heteroge...
FDA collaboration to improve safe use of fluoroquinolone antibiotics: an ex post facto matched control study of targeted...
Published in Pharmacy Practice
Objective: This ex post facto matched control study was conducted to evaluate the effect of targeted short-form messages or continuing medical education (CME) on fluoroquinolone prescribing among high prescribers. Methods: A total of 11,774 Medscape healthcare provider (HCP) members prescribing high volumes of fluoroquinolones were randomized into ...
Inpatient self-administered medication under the supervision of a multidisciplinary team: a randomized, controlled, blin...
Published in Pharmacy Practice
Background: Self-administered medication (SAM) is encouraged in many hospitals worldwide as it increases patients’ knowledge and understanding of their medication, but the effects on other outcomes, e.g. compliance or medication errors, were unclear. Objectives: To compare medication knowledge, adherence, medication errors, and hospital readmission...
A randomized control trial assessing the effect of a pharmaceutical care service on Syrian refugees’ quality of life and...
Published in Pharmacy Practice
Background: Syrian refugees residing in Jordan suffer from chronic illnesses, low quality of life (QoL) and anxiety. Pharmacists delivering the medication review service can have a role in improving this growing worldwide problem. Objectives: To assess the effect of the medication review service on QoL and anxiety scores for Syrian refugees living ...
Telerehabilitation for people with low vision.
BACKGROUND:Low vision affects over 300 million people worldwide and can compromise both activities of daily living and quality of life. Rehabilitative training and vision assistive equipment (VAE) may help, but some visually impaired people have limited resources to attend in-person visits at rehabilitation clinics to receive training to learn to u...
