Corroyer-Dulmont, Aurélien Valable, Samuel Fantin, Jade Chatre, Laurent Toutain, Jérôme Teulier, Sylvain Bazille, Céline Letissier, Elise Levallet, Jérôme Divoux, Didier
...
Published in
Scientific Reports
Lung cancer patients frequently develop brain metastases (BM). Despite aggressive treatment including neurosurgery and external-radiotherapy, overall survival remains poor. There is a pressing need to further characterize factors in the microenvironment of BM that may confer resistance to radiotherapy (RT), such as hypoxia. Here, hypoxia was first ...
Sotiropoulos, Marios Prezado, Yolanda
Published in
Scientific Reports
In proton minibeam radiation therapy, proton minibeams are typically produced by modulating a uniform field using a multislit collimator. Multislit collimators produce minibeams of fixed length and width, and a new collimator has to be manufactured each time a new minibeam array is required, limiting its flexibility. In this work, we propose a scan...
Mallet, R. Decazes, P. Modzelewski, R. Lequesne, J. Vera, P. Dubray, B. Thureau, S.
Published in
Scientific Reports
Low skeletal muscle mass is a well-known prognostic factor for patients treated for a non-small-cell lung cancer by surgery or chemotherapy. However, its impact in patients treated by exclusive radiochemotherapy has never been explored. Our study tries to evaluate the prognostic value of low skeletal muscle mass and other antropometric parameters o...
von der Grün, Jens Winkelmann, Ria Rödel, Franz Balster, Sven Neumayer, Thomas Ghanaati, Shahram Brandts, Christian Burck, Iris Martin, Daniel Rödel, Claus
...
Published in
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Salivary gland carcinomas (SGC) cover a heterogeneous group of malignancies with a lack of data of high-level evidence. Clinical data of 127 patients treated for SGC at a university cancer center between 2002 and 2017 were analyzed retrospectively. The association of clinicopathological characteristics, treatment modalities, adverse events, and out...
Cheng, Jing Liu, Beibei Wang, Biao Long, Xicui Li, Zhihong Chen, Ruili Wu, Ruiting Xu, Lin
Published in
BMC Cancer
Background Cervical cancer is a common malignancy of the female genital tract. Treatment options for cervical cancer patients diagnosed at FIGO (2009) stage IB2 and IIA2 remains controversial. Methods We perform a Bayesian network meta-analysis to directly or indirectly compare various interventions for FIGO (2009) IB2 and IIA2 disease, in order to...
Vilinovszki, Oliver Andratschke, Nicolaus Huellner, Martin Curioni-Fontecedro, Alessandra Kroeze, Stephanie G. C.
Published in
Radiation Oncology (London, England)
Background Systemic response to local anticancer treatment is a phenomenon called ‘abscopal effect’. The immune system is thought to play a pivotal role in its occurrence. To date, several cases have been reported, particularly in patients receiving combined local treatment and immune checkpoint inhibitors. In such cases, it is impossible to discri...
Liu, Ao Wang, Yalin Wang, Xin Zhu, Liqiong Nie, Yu Li, Minghuan
Published in
Radiation Oncology (London, England)
Background Whether adjuvant chemotherapy (AC) after concurrent chemoradiotherapy (CCRT) could provide benefit to esophageal squamous cell carcinoma (ESCC) patients is controversial. Therefore, we decided to investigate the potential benefit of AC after CCRT for ESCC and to identify biomarkers predictive of a clinical benefit. Methods We retrospecti...
Lee, Joo Ho Eom, Keun-Yong Phi, Ji Hoon Park, Chul-Kee Kim, Seung Ki Cho, Byung-Kyu Kim, Tae Min Heo, Dae Seog Hong, Kyung Taek Choi, Jung Yoon
...
Published in
Cancer research and treatment
We aimed to refine the radiotherapy (RT) volume and dose for intracranial germinoma considering recurrences and long-term toxicities. Total 189 patients with intracranial germinoma were treated with RT alone (n=50) and RT with upfront chemotherapy (CRT) (n=139). All cases were confirmed histologically. RT fields comprised the extended-field and inv...
Dieperink, Karin B Hansen, Steinbjørn Wagner, Lis Minet, Lisbeth R Hansen, Olfred
Published in
Journal of cancer survivorship : research and practice
In the Rehabilitation of Prostate Cancer (RePCa) study, the intervention reduced early adverse effects in prostate cancer 6 months after radiotherapy. This 3-year follow-up study assesses late adverse effects, evaluates rehabilitative long-term effects and identifies patients who benefit the most. RePCa was a randomized clinical trial with multidis...
Lee, Sung Jong Kim, Hee Youn Lee, Dong Sup
Published in
International urogynecology journal
Storage-phase bladder dysfunction can develop after pelvic radiotherapy. As the alpha-1d adrenoreceptor (a1d-AR) is dominant in the human detrusor, we aimed to investigate the effect of an a1d-AR antagonist on bladder dysfunction after pelvic radiotherapy in a rat model. Twenty-four female Wistar rats were used. Eight rats (14-15 weeks, 250-300 g) ...
