Liu, Yanmei Lou, Wilson Pak-Kin Fei, Ji-Feng
Published in
Cell Regeneration
A successful tissue regeneration is a very complex process that requires a precise coordination of many molecular, cellular and physiological events. One of the critical steps is to convert the injury signals into regeneration signals to initiate tissue regeneration. Although many efforts have been made to investigate the mechanisms triggering tiss...
Zhao, Feijie Hong, Xiaoling Li, Danjie Wei, Zhentong Ci, Xinxin Zhang, Songling
Published in
Medical Oncology
The fatality rate of ovarian cancer ranks first among gynecological tumors, and the prognosis is poor. Diosmetin (Dio), a natural flavonoid obtained from citrus fruits, has been shown to have anti-tumor effects in lung, liver, and skin cancers. We aimed to investigate the effects of Dio on ovarian cancer A2780 and SKOV3 cells along with the underly...
Lopes-Pires, M E Ahmed, N S Vara, D Gibbins, J M Pula, G Pugh, N
Published in
Platelets
Vascular complications resulting from atherosclerosis development are a major cause of death. Reactive oxygen species (ROS) are produced by platelets during activation, and have been demonstrated to positively regulate platelet activatory responses. Zn2+ is also an important hemostatic cofactor in platelets, acting both as a platelet agonist and se...
Geng, Shao-Lei Zhang, Xiao-Shuai Xu, Wei-Hua
Published in
The FEBS journal
Previous studies have shown that high physiological levels of reactive oxygen species (ROS) in the brain promote pupal diapause, which extends the pupal lifespan. However, the molecular mechanisms of ROS generation are unclear. In this paper, we found that mitochondrial ROS (mtROS) levels in the brains of Helicoverpa armigera diapause-destined pupa...
Zhang, Bin Wang, Yan Wu, Caihong Qiu, Shulei Chen, Xiaolan Cai, Bingyan Xie, Huimei
Published in
BMC Veterinary Research
BackgroundCryopreservation is an efficient way to store spermatozoa and is closely associated with the quality of sperm after the freeze-thaw process. During freeze-thaw cycling, excessive reactive oxygen species (ROS) are produced, and the effects of ROS on boar sperm during cryopreservation have not been identified.ResultsIn this study, we evalua...
Geng, Jiqun Yang, Kaihua
Published in
DNA and cell biology
Circular RNAs have been shown to regulate cancer tumorigenesis and drug resistance. Recently, circCCND1 is reported to promote laryngeal squamous cell carcinoma; however, whether circCCND1 is implicated in non-small cell lung cancer (NSCLC) remains unclear. In this research, The Cancer Genome Atlas data of lung adenocarcinoma were analyzed to show ...
Wu, Juan Cui, Dongmei Li, Honghui Zeng, Junwen
Published in
European journal of ophthalmology
Accumulation of endogenous all-trans retinoic acid (ATRA) plays a role in the degeneration of photoreceptor cells and retinal pigment epithelium (RPE) cells, contributing to age-related macular degeneration (AMD). This study attempted to investigate the influence of antioxidant N-acetylcysteine (NAC) and selective endoplasmic reticulum stress (ERS)...
Waghela, Bhargav N. Vaidya, Foram U. Pathak, Chandramani
Published in
Biochemistry (Moscow)
AbstractAltered expression of cellular redox genes and proteins contributes to invasion, metastasis, and drug resistance in cancer. NADPH oxidase (NOX) isoforms are the pro-oxidant enzymes that generate ROS as a primary product. Dysregulation of NOX activity and expression alters ROS generation, which either directly or indirectly modulates cell de...
Wang, Ssu-Han Chen, Yu-Lin Hsiao, Jenn-Ren Tsai, Fang-Yu Jiang, Shih Sheng Lee, Alan Yueh-Luen Tsai, Hui-Jen Chen, Ya-Wen
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundEctopic insulin-like growth factor binding protein 3 (IGFBP3) expression has been shown to enhance cell migration and lymph node metastasis of oral squamous cell carcinoma (OSCC) cells. However, OSCC patients with high IGFBP3 expression had improved survival compared with those with low expression. Therefore, we speculated that IGFBP3 exp...
Castelli, Serena Ciccarone, Fabio Tavian, Daniela Ciriolo, Maria Rosa
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundIn the last decades, the concept of metabolic rewiring as a cancer hallmark has been expanded beyond the “Warburg effect” and the importance of other metabolic routes, including lipid metabolism, has emerged. In cancer, lipids are not only a source of energy but are also required for the formation of membranes building blocks, signaling a...