Gao, Feng Wang, Xiao-Chen Luo, Zhi-Dan Hu, Guang-Quan Ma, Meng-Qing Liang, Yi Xu, Bang-Long Lin, Xian-He
Published in
ESC heart failure
Long non-coding RNA HOXA11-AS participated in heart disease. In this study, we aim to evaluate the potential roles of HOXA11-AS in atherosclerosis and its underlying mechanisms. The expression levels of HOXA11-AS in ox-LDL-treated HUVECs and arch tissues of high-fat diet-fed ApoE-/- mice (n = 10) were assessed by qRT-PCR. The effects of HOXA11-AS k...
Fan, Xinhui Li, Xiaoxing Liu, Huiruo Xu, Feng Ji, Xiaoping Chen, Yuguo Li, Chuanbao
Published in
Frontiers in Pharmacology
Diabetes mellitus (DM) often involves cardiovascular complications; however, treatment regimens are limited. ROCK1 (rho-associated coiled-coil containing protein kinase 1) serves as a pathological factor in several diabetic complications. Herein, we aimed to explore the effect of Fasudil (a ROCK1 inhibitor) on the progress of cardiac dysfunction in...
huang;, xu shaobo
Clusterin (CLU) is a heterodimeric glycoprotein that has been detected in diverse human tissues and implicated in many cellular processes. Accumulating evidence indicates that the expression of secreted CLU correlates with the progression of cancers. However, the molecular mechanisms underlying its tumor-suppressive roles are incompletely uncovered...
Wang, Huanlan Huang, Shenghua Hu, Taotao Fei, Shizhi Zhang, Huanqiao
Published in
BMC Endocrine Disorders
Circ_0000064 knockdown relieves HG-induced HK-2 cells injury. Circ_0000064 acts as a sponge of miR-532-3p. MiR-532-3p directly targets ROCK1. Supplementary Information The online version contains supplementary material available at 10.1186/s12902-022-00968-x.
Nie, Yingying Zhu, Xuedan Bu, Nan Jiang, Yang Su, Yue Pan, Keming Li, Shanshan
Published in
BMC cancer
Reportedly, circular RNA (circRNA) is a key modulator in the development of human malignancies. This work is aimed to probe the expression pattern, biological effects and mechanism of circ_0064288 on hepatocellular carcinoma (HCC) progression. The differentially expressed circRNA was screened by analyzing the expression profiles of circRNAs in HCC ...
Liu, Guoqing Zhu, Qiang Wang, Hao Zhou, Jianfeng Jiang, Bin
Published in
Aging (Albany NY)
Hepatoblastoma (HB) is the most common pediatric liver tumor. The significant tumor heterogeneity of HB leads to varied prognoses among children with the disease. Recent studies have suggested that long non-coding RNAs (lncRNAs) can serve as novel therapies for HB treatment. Thus, in this study, we aimed to reveal the function and mechanism of the ...
Geng, Zhuang Dong, Bingzi Lv, Wenshan Wang, Zhongchao Wang, Xiang Huang, YaJing Wang, Yangang Xu, Lili
Published in
Diabetology & Metabolic Syndrome
BackgroundDiabetic nephropathy (DN) is a critical and the most common microvascular complication and its pathogenesis is still faintly understood. Thus, this study was performed to examine the long non-coding RNA ZNFX1 Antisense Gene Protein 1 (lncRNA ZFAS1) biological function and mechanism of regulation in DN.MethodHuman glomerular mesangial cell...
Wang, Wei Yang, Tao Li, Dongsheng Huang, Yinpeng Bai, Guang Li, Qing
Published in
Journal of Translational Medicine
BackgroundLINC00491 was involved in some tumors development, but its function in liver cancer has not been reported. This study aimed to investigate LINC00491 expression and function in liver cancer progression.MethodsSixty liver cancer cases were enrolled. LINC00491, miR-324-5p and rho-associated kinase 1 (ROCK1) expression in liver cancer patient...
Yang, Qi Dong, Yu-Jie
Published in
Journal of Ovarian Research
BackgroundOvarian cancer (OC) is characterized by early metastasis and poor prognosis, which threatens the health of women worldwide. Small nucleolar RNA host gene 20 (SNHG20), a long noncoding RNA (lncRNA), has been verified to be significantly up-regulated in several tumors, including OC. MicroRNA-148a (miR-148a)/rho-kinase1 (ROCK1) axis plays an...
Wang, Qian-Lu Xing, Wei Yu, Can Gao, Min Deng, Long-Tian
Published in
Molecular immunology
It has been reported that ROCK1 participates in the progression of multiple diseases, including septic intestinal barrier, cardiac dysfunction and acute lung injury. However, its regulatory role and specific mechanism in sepsis-induced acute kidney injury (AKI) remain unclear. Cecal ligation puncture (CLP) was conducted to establish sepsis mouse mo...
