Shen, Zhibo Xue, Wenhua Zheng, Yuanyuan Geng, Qishun Wang, Le Fan, Zhirui Wang, Wenbin Yue, Ying Zhai, Yunkai Li, Lifeng
...
Published in
Cancer Cell International
BackgroundHepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Given the role of this signaling pathway, the primary therapeutic direction focuses on identifying and designing HGF inhibitors, anta...
Mongiardi, Maria Patrizia Merolle, Matilde Fustaino, Valentina Levi, Andrea Falchetti, Maria Laura
Published in
Aging clinical and experimental research
Endothelial cells senescence is a physiological process affecting vascular integrity. It can contribute to heart and arterial stiffening and remodeling, impaired angiogenesis, defective vascular repair, and with an increasing prevalence of atherosclerosis. Drugs used as antineoplastic therapies, targeting tumor as well as endothelial cells, can als...
Koutroumpa, Fotini A. Monsempes, Christelle François, Marie-Christine Severac, Dany Montagné, Nicolas Meslin, Camille Jacquin-Joly, Emmanuelle
Published in
Frontiers in Ecology and Evolution
Illumina-based transcriptome sequencing of chemosensory organs has become a standard in deciphering the molecular bases of chemical senses in insects, especially in non-model species. A plethora of antennal transcriptomes is now available in the literature, describing large sets of chemosensory receptors and binding proteins in a diversity of speci...
Xu, Hui-Hui Gan, Jun Xu, Dan-Ping Li, Lu Yan, Wei-Hua
Published in
Frontiers in Immunology
Human leukocyte antigen G (HLA-G) is known as a novel immune checkpoint molecule in cancer; thus, HLA-G and its receptors might be targets for immune checkpoint blockade in cancer immunotherapy. The aim of this study was to systematically identify the roles of checkpoint HLA-G molecules across various types of cancer. ONCOMINE, GEPIA, CCLE, TRRUST,...
Zhang, Aqin Liu, Mengxue Gu, Wei Chen, Ziyun Gu, Yuchen Pei, Lingfeng Tian, Rong
Published in
BMC Plant Biology
BackgroundAtractylodes lancea (Thunb.) DC, a medicinal herb belonging to the Asteraceae family, often faces severe drought stress during its growth. Until now, there has been no research on the effect of drought stress on the quality formation of A. lancea. Therefore, the present study aimed to study the effects of drought stress on A. lancea throu...
Lismer, Ariane Lambrot, Romain Lafleur, Christine Dumeaux, Vanessa Kimmins, Sarah
Published in
STAR protocols
In the field of epigenetic inheritance, delineating molecular mechanisms implicated in the transfer of paternal environmental conditions to descendants has been elusive. This protocol details how to track sperm chromatin intergenerationally. We describe mouse model design to probe chromatin states in single mouse sperm and techniques to assess pre-...
Takase, Hajime Hamanaka, Gen Ohtomo, Ryo Ishikawa, Hidehiro Chung, Kelly K. Mandeville, Emiri T. Lok, Josephine Fornage, Myriam Herrup, Karl Tse, Kai-Hei
...
Published in
Frontiers in Cell and Developmental Biology
White matter damage caused by cerebral hypoperfusion is a major hallmark of subcortical ischemic vascular dementia (SIVD), which is the most common subtype of vascular cognitive impairment and dementia (VCID) syndrome. In an aging society, the number of SIVD patients is expected to increase; however, effective therapies have yet to be developed. To...
Xiong, Qiuhong Song, Ning Li, Ping Fischer, Sarah Konertz, Roman Wagle, Prerana Glöckner, Gernot Wu, Changxin Eichinger, Ludwig
Published in
BMC Genomics
BackgroundAutophagy is an evolutionary ancient mechanism that sequesters substrates for degradation within autolysosomes. The process is driven by many autophagy-related (ATG) proteins, including the core members ATG9 and ATG16. However, the functions of these two core ATG proteins still need further elucidation. Here, we applied RNAseq and tandem ...
Grieco, Giuseppina E. Sebastiani, Guido Fignani, Daniela Brusco, Noemi Nigi, Laura Formichi, Caterina Licata, Giada Bruttini, Marco D’Aurizio, Romina Mathieu, Chantal
...
Published in
STAR Protocols
The identification and validation of circulating small non-coding RNA (sncRNA) as biomarkers for disease diagnosis, staging, and response to novel therapies is still a compelling challenge. Pre-analytical variables, such as storage temperature or blood hemolysis, and different analytical approaches affect sncRNA stability, detection, and expression...
Eddie, Brian J. Malanoski, Anthony P. Onderko, Elizabeth L. Phillips, Daniel A. Glaven, Sarah M.
Published in
Biofilm
Marinobacter spp. are opportunitrophs with a broad metabolic range including interactions with metals and electrodes. Marinobacter atlanticus strain CP1 was previously isolated from a cathode biofilm microbial community enriched from a sediment microbial fuel cell. Like other Marinobacter spp., M. atlanticus generates small amounts of electrical cu...
