farahani, ramin m.
Mitochondrial ATP synthesis is driven by harnessing the electrochemical gradient of protons (proton motive force) across the mitochondrial inner membrane via the process of chemiosmosis. While there is consensus that the proton gradient is generated by components of the electron transport chain, the mechanism by which protons are supplied to ATP sy...
fei, fei telatar, milhan tomasian, vanina chang, lisa gust, mariel yew, hooi dyer, tamerisa danilova, olga arias-stella, javier pillai, raju
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Recurrent fusions drive the pathogenesis of many hematological malignancies. Compared to routine cytogenetic/fluorescence in situ hybridization (FISH) studies, the RNA-based next-generation sequencing (NGS) fusion assay enables the identification of both known and novel fusions. In many cases, these recurrent fusions are crucial for diagnosis and a...
dansereau, stephen j. cui, hua dartawan, ricky p. sheng, jia
The notion of RNA-based therapeutics has gained wide attractions in both academic and commercial institutions. RNA is a polymer of nucleic acids that has been proven to be impressively versatile, dating to its hypothesized RNA World origins, evidenced by its enzymatic roles in facilitating DNA replication, mRNA decay, and protein synthesis. This is...
Sopić, Miron Vladimirov, Sandra Munjas, Jelena Mitić, Tijana Hall, Ignacio Fernando Jusic, Amela Ruzic, Dusan Devaux, Yvan
Published in
British journal of pharmacology
Noncoding RNAs (ncRNAs) are pivotal for various pathological processes, impacting disease progression. The potential for leveraging ncRNAs to prevent or treat atherosclerosis and associated cardiovascular diseases is of great significance, especially given the increasing prevalence of atherosclerosis in an ageing and sedentary population. Together,...
Montano, Christy Flores-Arenas, Cristina Carpenter, Susan
Long noncoding RNAs (LncRNAs) are key regulators of gene expression and can mediate their effects in both the nucleus and cytoplasm. Some of the best-characterized lncRNAs are localized within the nucleus, where they modulate the nuclear architecture and influence gene expression. In this review, we discuss the role of lncRNAs in nuclear architectu...
klabenkova, kristina zakhryamina, alyona burakova, ekaterina bizyaev, sergei fokina, alesya stetsenko, dmitry
Nowadays, nucleic acid derivatives capable of modulating gene expression at the RNA level have gained widespread recognition as promising therapeutic agents. A suitable degree of biological stability of oligonucleotide therapeutics is required for in vivo application; this can be most expeditiously achieved by the chemical modification of the inter...
Davey-Young, Josephine Hasan, Farah Tennakoon, Rasangi Rozik, Peter Moore, Henry Hall, Peter Cozma, Ecaterina Genereaux, Julie Hoffman, Kyle S Chan, Patricia P
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Translation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do not recognize the anticodon bases. Single nucleotide anticodon variants in their cognate tRNAs can lead to mistranslation. Human genomes include both rare ...
Forlano, R Martinez-Gili, L Takis, P Miguens-Blanco, J Liu, T Triantafyllou, E Skinner, C Loomba, R Thursz, M Marchesi, JR
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Aberration of the "gut-liver axis" contributes to the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we use multi-omics to analyze the gut microbiota composition and metabolic profile of patients with type-2 diabetes mellitus (T2DM). T2DM patients were screened for liver disease by blood tests...
Mohammadi, Aida Chiang, Samantha Li, Feng Wei, Fang Lau, Chang Aziz, Mohammad Ibarrondo, Francisco Fulcher, Jennifer Yang, Otto Chia, David
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We developed a 4-parameter clinical assay using Electric Field Induced Release and Measurement (EFIRM) technology to simultaneously assess SARS-CoV-2 RNA (vRNA), nucleocapsid antigen, host binding (BAb) and neutralizing antibody (NAb) levels from a drop of saliva with performance that equals or surpasses current EUA-approved tests. The vRNA and ant...
liu, runhan zhou, jiaxin chen, xiaochen zhang, jie chen, qunzhi liu, xiaoming yao, kunhou
Gastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding and non-coding RNAs as emerging biomarkers for these malignancies, detectable by liquid biopsies, and as innovative the...
