de Miranda, Joachim R. Brettell, Laura E. Chejanovsky, Nor Childers, Anna K. Dalmon, Anne Deboutte, Ward de Graaf, Dirk C. Doublet, Vincent Gebremedhn, Haftom Genersch, Elke
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Published in
Virology Journal
In 1977, a sample of diseased adult honeybees (Apis mellifera) from Egypt was found to contain large amounts of a previously unknown virus, Egypt bee virus, which was subsequently shown to be serologically related to deformed wing virus (DWV). By sequencing the original isolate, we demonstrate that Egypt bee virus is in fact a fourth unique, major ...
Farooqi, Ammad Ahmad Fayyaz, Sundas Poltronieri, Palmiro Calin, George Mallardo, Massimo
Published in
Seminars in cancer biology
Data obtained from cutting-edge research have shown that deregulated epigenetic marks are critical hallmarks of cancer. Rapidly emerging scientific evidence has helped in developing a proper understanding of the mechanisms leading to control of cellular functions, from changes in chromatin accessibility, transcription and translation, and in post-t...
Caterino, Marco Paeschke, Katrin
Published in
Methods (San Diego, Calif.)
The nucleic acid structure called G-quadruplex (G4) is currently discussed to function in nucleic acid-based mechanisms that influence several cellular processes. They can modulate the cellular machinery either positively or negatively, both at the DNA and RNA level. The majority of what we know about G4 biology comes from DNA G4 (dG4) research. RN...
Cani, Andi K Hu, Kevin Liu, Chia-Jen Siddiqui, Javed Zheng, Yingye Han, Sumin Nallandhighal, Srinivas Hovelson, Daniel H Xiao, Lanbo Pham, Trinh
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Published in
European urology oncology
Despite biomarker development advances, early detection of aggressive prostate cancer (PCa) remains challenging. We previously developed a clinical-grade urine test (Michigan Prostate Score [MiPS]) for individualized aggressive PCa risk prediction. MiPS combines serum prostate-specific antigen (PSA), the TMPRSS2:ERG (T2:ERG) gene fusion, and PCA3 l...
Zhao, Chuanxiang Xu, Guoying Zhang, Xiaoxian Ye, Yunfeng Cai, Weili Shao, Qixiang
Published in
Frontiers in Immunology
RNA, one of the major building blocks of the cell, participates in many essential life processes. RNA stability is well-established to be closely related to various RNA modifications. To date, hundreds of different RNA modifications have been identified. N6-methyladenosine (m6A) is one of the most important RNA modifications in mammalian cells. An ...
Zappa, Francesca Muniozguren, Nerea L Wilson, Maxwell Z Costello, Michael S Ponce-Rojas, Jose Carlos Acosta-Alvear, Diego
The double-stranded RNA sensor kinase PKR is one of four integrated stress response (ISR) sensor kinases that phosphorylate the α subunit of eukaryotic initiation factor 2 (eIF2α) in response to stress. The current model of PKR activation considers the formation of back-to-back PKR dimers as a prerequisite for signal propagation. Here we show that ...
Jin, Yuanting Aguilar-Gómez, Diana Y C Brandt, Débora Square, Tyler A Li, Jiasheng Liu, Zhengxia Wang, Tao Sudmant, Peter H Miller, Craig T Nielsen, Rasmus
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The variegated toad-headed agama, Phrynocephalus versicolor, lives in the arid landscape of the Chinese Gobi Desert. We analyzed populations from three different locations which vary in substrate color and altitude: Heishankou (HSK), Guazhou County (GZ), and Ejin Banner (EJN). The substrate color is either light-yellow (GZ-y), yellow (EJN-y), or bl...
Nanjo, Shigeki Wu, Wei Karachaliou, Niki Blakely, Collin M Suzuki, Junji Chou, Yu-Ting Ali, Siraj M Kerr, D Lucas Olivas, Victor R Shue, Jonathan
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Molecularly targeted cancer therapy has improved outcomes for patients with cancer with targetable oncoproteins, such as mutant EGFR in lung cancer. Yet, the long-term survival of these patients remains limited, because treatment responses are typically incomplete. One potential explanation for the lack of complete and durable responses is that onc...
Vogt, Guido Verheyen, Sarah Schwartzmann, Sarina Ehmke, Nadja Potratz, Cornelia Schwerin-Nagel, Anette Plecko, Barbara Holtgrewe, Manuel Seelow, Dominik Blatterer, Jasmin
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Published in
Journal of medical genetics
Genes implicated in the Golgi and endosomal trafficking machinery are crucial for brain development, and mutations in them are particularly associated with postnatal microcephaly (POM). Exome sequencing was performed in three affected individuals from two unrelated consanguineous families presenting with delayed neurodevelopment, intellectual disab...
Chen, Tao Cao, Chen Zhang, Jianyun Streets, Aaron Li, Tiejun Huang, Yanyi
Both the composition of cell types and their spatial distribution in a tissue play a critical role in cellular function, organ development, and disease progression. For example, intratumor heterogeneity and the distribution of transcriptional and genetic events in single cells drive the genesis and development of cancer. However, it can be challeng...
