Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair
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10.1136/gutjnl-2020-322779 / GUT / 70 / 10 / 1833-1846
Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-...
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Hematopoietic stem and progenitor cell (HSPC) engraftment after transplantation during anticancer treatment depends on support from the recipient bone marrow (BM) microenvironment. Here, by studying physiological homing of fetal HSPCs, we show the critical requirement of balanced local crosstalk within the skeletal niche for successful HSPC settlem...
A fast and efficient method for selective extraction of lithium from spent lithium iron phosphate battery
A new recovery method for fast and efficient selective leaching of lithium from lithium iron phosphate cathode powder is proposed. Lithium is expelled out of the Oliver crystal structure of lithium iron phosphate due to oxidation of Fe2+ into Fe3+ by ammonium persulfate. 99% of lithium is therefore leached at 40 degrees C with only 1.1 times the am...
A fast and efficient method for selective extraction of lithium from spent lithium iron phosphate battery
A new recovery method for fast and efficient selective leaching of lithium from lithium iron phosphate cathode powder is proposed. Lithium is expelled out of the Oliver crystal structure of lithium iron phosphate due to oxidation of Fe2+ into Fe3+ by ammonium persulfate. 99% of lithium is therefore leached at 40 degrees C with only 1.1 times the am...
Lattice implants that generate homeostatic and remodeling strains in bone
Bone remodeling is mediated by several factors including strain. An increase in strain between 1% and 10% compared to homeostasis can trigger bone formation. We aim to create an orthopedic implant using clinically established imaging and manufacturing methods that induces this strain control in human bone. Titanium scaffolds were manufactured with ...
Bone morphogenetic protein 2-induced cellular chemotaxis drives tissue patterning during critical-sized bone defect heal...
Critical-sized bone defects are critical healing conditions that, if left untreated, often lead to non-unions. To reduce the risk, critical-sized bone defects are often treated with recombinant human BMP-2. Although enhanced bone tissue formation is observed when BMP-2 is administered locally to the defect, spatial and temporal distribution of call...
Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila
Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of multiple stem cell niches. However, its role in adult intestinal homeostasis remains largely understudied. Here we uncover a previously unrecognised crosstalk betw...
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation
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Tissue damage dramatically alters how cells interact with their microenvironment. These changes in turn dictate cellular responses, such as stem cell activation, yet early cellular responses in vivo remain ill defined. We generated single-cell and nucleus atlases from intact, dissociated, and injured muscle and liver and identified a common stress ...
Toward adipose tissue engineering using thiol-norbornene photo-crosslinkable gelatin hydrogels
Nowadays, breast implants, lipofilling, and microsurgical free tissue transfer are the most often applied procedures to repair soft tissue defects resulting from mastectomies/lumpectomies following breast cancer. Due to the drawbacks and limitations associated with these conventional clinical practices, there is a need for alternative reconstructiv...
A calmodulin antagonist protects in vitro raspberries against disturbed photosynthesis caused by constant light and cyto...
Leaf chlorosis is often a problem in micropropagated Rubus idaeus, which makes successful acclimatization difficult. We found that leaf bleaching becomes extreme when in vitro plants are exposed to continuous fluorescent light in the presence of 6-benzyl adenine (BA) or isopentenyl adenine (2iP). These cytokinins had a profound negative effect on t...
