The genetics of gaits in Icelandic horses goes beyond DMRT3, with RELN and STAU2 identified as two new candidate genes
status: published
status: published
Although large-scale genome-wide association studies (GWAS) have identified an association between
Published in Stem Cell Reports
Park et al. have established and demonstrated the successful use of TUJ1EGFP/NGN2TagRFP dual-reporter induced pluripotent stem cells to monitor human neural differentiation in 2D and 3D culture systems. They also document the responses of fluorescent signals to drugs and genetic manipulations affecting neural differentiation. Furthermore, the knock...
Published in Cell stem cell
Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair. Epithelial stem cells of small and large intestines (ISCs) respond to their local microenvironments (niches) to fulfill a continuous demand for tissue turnover. The complexity of these niches and underlying communication pathways are not fully known. Here, we re...
Focal malformations of cortical development (FMCDs) account for the majority of drug-resistant pediatric epilepsy. Postzygotic somatic mutations activating the phosphatidylinositol-4,5-bisphosphate-3-kinase (PI3K)-protein kinase B (AKT)-mammalian target of rapamycin (mTOR) pathway are found in a wide range of brain diseases, including FMCDs. It rem...
European Commission
European Commission
European Commission
10.1074/jbc.M110.123729 / JOURNAL OF BIOLOGICAL CHEMISTRY / 285 / 26 / 19720-19726
An abnormality in neurodevelopment is one of the most robust etiologic hypotheses in schizophrenia (SZ). There is also strong evidence that genetic factors may influence abnormal neurodevelopment in the disease. The present study evaluated in SZ patients, whose brain structural data had been obtained with magnetic resonance imaging (MRI), the possi...