Dennison, Lauren Mohan, Aditya A. Yarchoan, Mark
Published in
Current Oncology Reports
AbstractPurpose of ReviewMitogen-activated protein kinase (MAPK) kinase (MEK) is an integral component of the RAS signaling pathway, one of the most frequently mutated pathways in cancer biology. MEK inhibitors were initially developed to directly target oncogenic signaling, but are recognized to have pleiotropic effects on both tumor cells and lym...
Thein, Kyaw Z. Biter, Amadeo B. Hong, David S.
Aberrations in rat sarcoma (RAS) viral oncogene are the most prevalent and best-known genetic alterations identified in human cancers. Indeed, RAS drives tumorigenesis as one of the downstream effectors of EGFR activation, regulating cellular switches and functions and triggering intracellular signaling cascades such as the MAPK and PI3K pathways. ...
Li, Yan-Ping Ma, Ya Wang, Ningli Jin, Zi-Bing
Published in
Stem Cell Research
Recently, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has spread around the world and is receiving worldwide attention. Approximately 20% of infected patients are suffering from severe disease of multiple systems and in danger of death, while the ocular complications of SARS-CoV-2-infected patients have not been reported generally. Her...
Grit, Jamie L. Johnson, Benjamin K. Dischinger, Patrick S. J. Essenburg, Curt Adams, Marie Campbell, Stacy Pollard, Kai Pratilas, Christine A. Triche, Tim J. Jr. Graveel, Carrie R.
...
Published in
Epigenetics & Chromatin
Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share nearly identical histology, but maintain different growth rates and risk of malignant conversion. The reasons for this disparate clinical be...
Han, Jing Liu, Yang Yang, Sen Wu, Xuan Li, Hongle Wang, Qiming
Published in
Journal of Hematology & Oncology
BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAPK signaling pathway. Concomitant mutations in both KRAS and BRAF genes have been identified in non-small cell lung cancer (NSCLC). They lead to the proliferation, differentiation, and apoptosis of tumor cells by activating the RAS/RAF/MEK/ERK signaling pathway. To date, agents that target RA...
Panizo, Sara Martínez-Arias, Laura Alonso-Montes, Cristina Cannata, Pablo Martín-Carro, Beatriz Fernández-Martín, José L. Naves-Díaz, Manuel Carrillo-López, Natalia Cannata-Andía, Jorge B.
Published in
International Journal of Molecular Sciences
Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix as a response to different types of tissue injuries, which leads to organ dysfunction. The process can be initiated by multiple and different stimuli and pathogenic factors which trigger the cascade of reparation converging in molecular signals responsible ...
Liu, Yan Gao, Galen F Minna, John D Williams, Noelle S Westover, Kenneth D
Published in
Lung cancer (Amsterdam, Netherlands)
Wild type RAS (RASWT) suppresses the function of oncogenic RAS mutants (RASMUT) in laboratory models. Loss of RASWT, which we termed loss of heterozygosity (LOH) for any RAS (LAR) or LAKR in the context of KRAS (LOH at KRAS), is found in patients with RASMUT cancers. However, the incidence and prognostic significance of LAR has not been studied in ...
Sheffels, Erin Sealover, Nancy E Theard, Patricia L Kortum, Robert L
Published in
Small GTPases
The RAS family of genes (HRAS, NRAS, and KRAS) is mutated in around 30% of human tumours. Wild-type RAS isoforms play an important role in mutant RAS-driven oncogenesis, indicating that RasGEFs may play a significant role in mutant RAS-driven transformation. We recently reported a hierarchical requirement for SOS2 in mutant RAS-driven transformatio...
Dong, Xubin Song, Jingjing Hu, Jing Zheng, Cheng Zhang, Xiaohua Liu, Haiguang
Published in
Frontiers in Cell and Developmental Biology
Papillary thyroid cancer (PTC) is the most common malignant disease in endocrine systems. T-box transcription factor 22 (TBX22) is a phylogenetically conserved family member that has not been widely characterized in cancers. In this study, we explored the potential clinical significance and biological functions of TBX22 in PTC. Comprehensive analys...
Franco, Rafael Lillo, Alejandro Rivas-Santisteban, Rafael Rodríguez-Pérez, Ana I. Reyes-Resina, Irene Labandeira-García, José L. Navarro, Gemma
Published in
International Journal of Molecular Sciences
Angiotensin-converting enzyme 2 (ACE2) is a membrane peptidase and a component of the renin-angiotensin system (RAS) that has been found in cells of all organs, including the lungs. While ACE2 has been identified as the receptor for severe acute respiratory syndrome (SARS) coronaviruses, the mechanism underlying cell entry remains unknown. Human im...