Volik, Pavel I Kopeina, Gelina S Zhivotovsky, Boris Zamaraev, Alexey V
Published in
Trends in molecular medicine
The PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell di...
Sidi, Samuel Bouchier-Hayes, Lisa
Published in
Molecular & cellular oncology
Despite being frequently mutated or deregulated in acute myeloid leukemia (AML) and many other cancers, the mechanisms by which nucleophosmin (NPM1) regulates oncogenesis remain elusive. We found that NPM1 plays a direct and conserved role in DNA damage-induced assembly of the PIDDosome complex, the activating platform for caspase-2. This function ...
Maney, Sathish Kumar Xu, Haifeng C. Huang, Jun Pandyra, Aleksandra A. Ehlting, Christian Aguilar-Valenzuela, Renan Pozdeev, Vitaly I. McIlwain, David R. Zimmermann, Albert Bode, Johannes G.
...
Published in
Cellular Physiology and Biochemistry
Background/Aims: Viral infections represent a global health problem with the need for new viral therapies and better understanding of the immune response during infection. The most immediate and potent anti-viral defense mechanism is the production of type I interferon (IFN-I) which are activated rapidly following recognition of viral infection by ...
Shah, Richa B Thompson, Ruth Sidi, Samuel
Published in
Molecular & cellular oncology
In contrast to the apoptosome and death-inducing signaling complex, the PIDDosome remains an orphan caspase activation platform unassigned to a specific apoptotic pathway. We found that DNA damage-induced PIDDosome formation is blocked by the mitotic checkpoint factor BUBR1 (budding uninhibited by benzimidazole-related 1), via a direct interaction ...
Medrano, Juan F. Horvat, Simon
Smith, Jacueline Paton, Robert Ian Horvat, Simon Burt, David William
Jang, Tae-Ho Seo, En Kyung Park, Hyun Ho
Published in
Applied Biochemistry and Biotechnology
PIDDosome is a recently-identified caspase-2-activating molecular complex formed by genotoxic stress that leads to caspase-2-dependent apoptosis. PIDD, RAIDD, and caspase-2 are three protein components of PIDDosome. The core portion of PIDDosome is formed by the unique screw rotation of seven RAIDD DD and five PIDD DD. In the current study, we foun...
Jang, Tae-Ho Lee, Sung-Jun Woo, Chang-Hoon Lee, Kyung Jin Jeon, Ju-Hong Lee, Dong-Sup Choi, Kihang Kim, In-Gyu Kim, Young Whan Lee, Tae-Jin
...
Published in
Biochemical Pharmacology
Jang, Tae-ho Zheng, Chao Wu, Hao Jeon, Ju-Hong Park, Hyun Ho
Published in
Apoptosis
Caspase-2 is critical for genotoxic stress induced apoptosis and is activated by formation of the PIDDosome, an oligomeric caspase-2 activating complex. The PIDDosome comprises three protein components, PIDD, RAIDD, and caspase-2. RAIDD contains both a death domain (DD) and a caspase recruitment domain (CARD). It acts as the bridge to recruit PIDD ...
Yang, Cao Hornicek, Francis J. Wood, Kirkham B. Schwab, Joseph H. Mankin, Henry Duan, Zhenfeng
Published in
Cancer Chemotherapy and Pharmacology
PurposeTo identify the apoptosis genes involved in the multidrug resistant phenotype of osteosarcoma.MethodsMultidrug resistant human osteosarcoma cell line (U-2 OS MR) and a drug sensitive parental cell line (U-2 OS) were both treated with paclitaxel and analyzed by the gene array containing 96 apoptosis associated genes. The different expression ...
