Zuccarello, Elisa Zhang, Hong Acquarone, Erica Pham, Dang Staniszewski, Anna Deng, Shi-Xian Landry, Donald W Arancio, Ottavio Fiorito, Jole
Published in
Bioorganic & medicinal chemistry letters
Phosphodiesterase 5 (PDE5) is a cyclic guanosine monophosphate-degrading enzyme involved in numerous biological pathways. Inhibitors of PDE5 are important therapeutics for the treatment of neurodegenerative diseases, including Alzheimer's disease (AD). We previously reported the first generation of quinoline-based PDE5 inhibitors for the treatment ...
Kumar, Nitish Khanna, Aanchal Kaur, Komalpreet Kaur, Harmandeep Sharma, Anchal Bedi, Preet Mohinder Singh
Published in
Molecular diversity
Emergence of antimicrobial resistance has become a great threat to human species as there is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR by initiating research and developing new novel antimicrobial agents. Among phytoconstituents, Quinoline (nitrogen containing heterocyclic) have played a wide role in provi...
Li, Kun Xu, Yuanbo Sun, Jun Zhang, Wei Ma, Peizhi
Published in
Anti-cancer agents in medicinal chemistry
Cancer is a major public health problem worldwide, and is the leading cause of death. The discovery and development of cancer therapeutic drugs have become the most urgent measure, which significantly benefited from the usage of small molecule compounds. The quinoline core possessed a vast number of biological activities that were found to be imper...
Pradhan, Vikas Salahuddin, Kumar, Rajnish Mazumder, Avijit Abdullah, Mohammad Mustaqeem Shahar Yar, Mohammad Ahsan, Mohamed Jawed Ullah, Zabih
Published in
Chemical biology & drug design
One of the leading causes of death worldwide is cancer, which poses substantial risks to both society and an individual's life. Cancer therapy is still challenging, despite developments in the field and continued research into cancer prevention. The search for novel anticancer active agents with a broader cytotoxicity range is therefore continuousl...
Van Thong, Pham; Van Meervelt, Luc; 14577; Chi, Nguyen Thi Thanh;
status: published
Gnawali, Giri R Okumura, Koichi Perez, Karolina Gallagher, Rosa Wulfkuhle, Julia Petricoin, Emanuel F Padi, Sathish Kumar Reddy Bearss, Jeremiah He, Zhiyong Wang, Wei
...
Published in
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents
Wang, Minghua Zhang, Guoning Zhao, Jianyuan Cheng, Ningning Wang, Yujia Fu, Yuanhui Zheng, Yanpeng Wang, Juxian Zhu, Mei Cen, Shan
...
Published in
European journal of medicinal chemistry
We report herein the synthesis of a series of novel quinoline derivatives, based on the lead compound 1a, identified from a rRSV-mGFP high-throughput screening assay. Our results revealed that target compounds 1b, 1g-h, 1af and 1ah (IC50 = 3.10-6.93 μM) had good in vitro activity against RSV, which were better than 1a and ribavirin. In addition, we...
Dib, Mustapha Ouchetto, Hajiba Ouchetto, Khadija Hafid, Abderrafia Khouili, Mostafa
Published in
Current organic synthesis
Heterocyclic compounds containing the quinoline ring play a significant role in organic synthesis and therapeutic chemistry. Polyfunctionalized quinolines have attracted the attention of many research groups, especially those who work on drug discovery and development. These derivatives have been widely explored by the research biochemists and are ...
da Rosa Monte Machado, Gabriella Diedrich, Denise Ruaro, Thaís Carine Zimmer, Aline Rigon Lettieri Teixeira, Mário de Oliveira, Luís Flávio Jean, Mickael Van de Weghe, Pierre de Andrade, Saulo Fernandes Baggio Gnoatto, Simone Cristina
...
Published in
Brazilian Journal of Microbiology
Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines d...
Tabassum, Rukhsana Ashfaq, Muhammad Oku, Hiroyuki
Published in
Heliyon
We have developed a new and facile one pot three component protocol catalyzed by ammonium acetate for construction of new functionalized 7-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives. A variety of quinoline derivatives were obtained in good to excellent yield from inexpensive reagents and catalyst in mild reaction conditions that provide atom...
