Amgad, Mohamed Stovgaard, Elisabeth Specht Balslev, Eva Thagaard, Jeppe Chen, Weijie Dudgeon, Sarah Sharma, Ashish Kerner, Jennifer K. Denkert, Carsten Yuan, Yinyin
...
Published in
npj Breast Cancer
Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variabili...
Annaert, Wim; 3594; Kaether, Christoph;
The quote "bring it back, bring it back, don't take it away from me" from Queen's Love of my life describes the function of the sorting receptor RER1, a 23 kDa protein with four transmembrane domains (TMDs) that localizes to the intermediate compartment and the cis-Golgi. From there it returns escaped proteins that are not supposed to leave the end...
Nagrani, Rajini Foraita, Ronja Gianfagna, Francesco Iacoviello, Licia Marild, Staffan Michels, Nathalie Molnár, Dénes Moreno, Luis Russo, Paola Veidebaum, Toomas
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Published in
Scientific Reports
As the prevalence of metabolic syndrome (MetS) in children and young adults is increasing, a better understanding of genetics that underlie MetS will provide critical insights into the origin of the disease. We examined associations of common genetic variants and repeated MetS score from early childhood to adolescence in a pan-European, prospective...
Cannaert, Annelies Ramírez Fernández, Maria Del Mar Theunissen, Eef L Ramaekers, Johannes G Wille, Sarah M R Stove, Christophe P
Published in
Analytical chemistry
The rapid proliferation of new synthetic cannabinoid receptor agonists (SCRAs) has initiated considerable interest in the development of so-called "untargeted" screening strategies. One of these new screening technologies involves the activity-based detection of SCRAs. In this study, we evaluated whether (synthetic) cannabinoid activity can be dete...
Yang, Yanli Song, Yanmin Lin, Xuan Li, Shuai Li, Zhengjun Zhao, Qizu Ma, Guanghui Zhang, Songping Su, Zhiguo
Destruction of assembly structures has been identified as a major cause for activity loss of virus and virus-like particles during their chromatographic process. A deep insight into the denaturation process at the solid-liquid interfaces is important for rational design of purification. In this study, in-situ differential scanning calorimetry (DSC)...
Yang, Yanli Song, Yanmin Lin, Xuan Li, Shuai Li, Zhengjun Zhao, Qizu Ma, Guanghui Zhang, Songping Su, Zhiguo
Destruction of assembly structures has been identified as a major cause for activity loss of virus and virus-like particles during their chromatographic process. A deep insight into the denaturation process at the solid-liquid interfaces is important for rational design of purification. In this study, in-situ differential scanning calorimetry (DSC)...
Song, Yanmin Yang, Yanli Lin, Xuan Li, Xiunan Zhang, Xuan Ma, Guanghui Su, Zhiguo Zhang, Songping
Adjuvants are important to enhance the antigens immunogenicity, but may also alter the structures of antigens. Currently off-line methods for adjuvants induced antigen alteration suffer from incomplete release and possible structural alteration of antigens. Here we investigated the differential scanning fluorimetry (DSF) as an in-situ and high-thro...
Song, Yanmin Yang, Yanli Lin, Xuan Li, Xiunan Zhang, Xuan Ma, Guanghui Su, Zhiguo Zhang, Songping
Adjuvants are important to enhance the antigens immunogenicity, but may also alter the structures of antigens. Currently off-line methods for adjuvants induced antigen alteration suffer from incomplete release and possible structural alteration of antigens. Here we investigated the differential scanning fluorimetry (DSF) as an in-situ and high-thro...
Van Paemel, Ruben De Koker, Andries Caggiano, Christa Morlion, Annelien Mestdagh, Pieter De Wilde, Bram Vandesompele, Jo De Preter, Katleen
The methylation pattern of cfDNA, isolated from liquid biopsies, is gaining substantial interest for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood collection tube and time delay between blood draw and plasma preparation on bisulphite-based cfDNA methylation profiling. Fifteen tubes of blood were drawn from thre...
Geeurickx, Edward Hendrix, An
Assessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection, tumor dynamics assessment, minimal residual disease detection and therapy monitoring. However, few liquid biopsy tests progress towards clinical application because res...
