Zhang, Xinwu Song, Xixi Hu, Guangchun Yang, Yaqing Liu, Ruotong Zhou, Na Basu, Sankar Qiao, Dongdong Hou, Qingzhen
Published in
Computational and structural biotechnology journal
Disrupted genes linked to mental disorders sometimes exhibit characteristics of Intrinsically Disordered Proteins (IDPs). However, few studies have comprehensively explored the functional associations between protein disorder properties and different psychiatric disorders. In this study, we collected disrupted proteins for seven mental diseases (MD...
Gallop, Lucy Westwood, Samuel J Lewis, Yael Campbell, Iain C Schmidt, Ulrike
Published in
European child & adolescent psychiatry
Transcranial direct current stimulation (tDCS) has demonstrated benefits in adults with various psychiatric disorders, but its clinical utility in children and young people (CYP) remains unclear. This PRISMA systematic review used published and ongoing studies to examine the effects of tDCS on disorder-specific symptoms, mood and neurocognition in ...
Louiset, Robin
The biological mechanisms that underlie the symptoms of psychiatric diseases, such as schizophrenia, bipolar, or autistic disorders, are still poorly understood in many regards.One of the main reasons is the neurobiological heterogeneity associated with these diseases. Furthermore, healthy subjects usually share common but irrelevant factors of var...
Tsui, Yen-Chen He, Minhao Hu, Yuwen Lake, Ethan Wang, Taige Watanabe, Kenji Taniguchi, Takashi Zaletel, Michael P Yazdani, Ali
Wigner predicted that when the Coulomb interactions between electrons become much stronger than their kinetic energy, electrons crystallize into a closely packed lattice1. A variety of two-dimensional systems have shown evidence for Wigner crystals2-11 (WCs). However, a spontaneously formed classical or quantum WC has never been directly visualized...
Zambon, Alice Rico, Laura Cuenca Herman, Mathieu Gundacker, Anna Telalovic, Amina Hartenberger, Lisa-Marie Kuehn, Rebekka Romanov, Roman A Hussaini, S Abid Harkany, Tibor
...
Published in
Molecular psychiatry
Immune activation is one of the most common complications during pregnancy, predominantly evoked by viral infections. Nevertheless, how immune activation affects mother-offspring relationships postpartum remains unknown. Here, by using the polyinosinic-polycytidylic acid (Poly I:C) model of gestational infection we show that viral-like immune activ...
Chu, Hongyuan Wang, Bing Zhao, Xinyu Mu, Li
Published in
Journal of affective disorders
Psychiatric comorbidities are relatively common among patients with epilepsy; however, the underlying mechanisms of this association remain largely unknown. The objective of this Mendelian randomization (MR) study was to analyze the genetic correlations and causality underlying these reciprocal associations. Single-nucleotide polymorphisms associat...
Lopes-Marques, Mónica Mort, Matthew Carneiro, João Azevedo, António Amaro, Andreia P Cooper, David N Azevedo, Luísa
Published in
Human genomics
De novo mutations (DNMs) are variants that occur anew in the offspring of noncarrier parents. They are not inherited from either parent but rather result from endogenous mutational processes involving errors of DNA repair/replication. These spontaneous errors play a significant role in the causation of genetic disorders, and their importance in the...
Xue, Hua Liu, Shuangjuan Zeng, Li Fan, Wenhui
Published in
Journal of affective disorders
This study aims to investigate the association between systemic lupus erythematosus (SLE) and the risk of seven psychiatric disorders through the application of Mendelian randomization (MR) analysis due to previous observational studies that have suggested a potential link between SLE and psychiatric disorders. We collected genetic instruments for ...
Dufumier, Benoit Gori, Pietro Petiton, Sara Louiset, Robin Mangin, Jean-François Grigis, Antoine Duchesnay, Edouard
The perspective of personalized medicine for brain disorders requires efficient learning models for anatomical neuroimagingbased prediction of clinical conditions. There is now a consensus on the benefit of deep learning (DL) in addressing many medical imaging tasks, such as image segmentation. However, for single-subject prediction problems, recen...
Parker, Nadine Cheng, Weiqiu Hindley, Guy F L O'Connell, Kevin S Karthikeyan, Sandeep Holen, Børge Shadrin, Alexey A Rahman, Zillur Karadag, Naz Bahrami, Shahram
...
Published in
Biological psychiatry
For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This may be driven in part by shared genetic architecture. Therefore, we investigated the phenotypic and genetic associations linking global cortical surface area and thickness with blood immune m...
