Khomari, Fateme Nabi-Afjadi, Mohsen Yarahmadi, Sahar Eskandari, Hanie Bahreini, Elham
Published in
Biological Procedures Online
The proteostasis network includes all the factors that control the function of proteins in their native state and minimize their non-functional or harmful reactions. The molecular chaperones, the important mediator in the proteostasis network can be considered as any protein that contributes to proper folding and assembly of other macromolecules, t...
Meller, Anatoly Shalgi, Reut
Published in
Experimental Cell Research
The aging proteostasis decline manifests in a failure of aging cells and organisms to properly respond to proteotoxic challenges. This proteostasis collapse has long been considered a hallmark of aging in nematodes, and has recently been shown to occur also in human cells upon entry to senescence, opening the way to exploring the phenomenon in the ...
van Oosten-Hawle, Patricija Bergink, Steven Blagg, Brian Brodsky, Jeff Edkins, Adrienne Freeman, Brian Genest, Olivier Hendershot, Linda Kampinga, Harm Johnson, Jill
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Published in
Cell Stress & Chaperones
Members of the Cell Stress Society International (CSSI), Patricija van Oosten-Hawle (University of Leeds, UK), Mehdi Mollapour (SUNY Upstate Medical University, USA), Andrew Truman (University of North Carolina at Charlotte, USA) organized a new virtual meeting format which took place on November 5–6, 2020. The goal of this congress was to provide ...
Besemer, Anna S Maus, Joanna Ax, Mirjam D A Stein, Anna Vo, Stella Freese, Christian Nalbach, Karsten von Hilchen, Christian Pfalzgraf, Ines F Koziollek-Drechsler, Ingrid
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Published in
Cellular and molecular life sciences : CMLS
The cellular protein homeostasis (proteostasis) network responds effectively to insults. In a functional screen in C. elegans, we recently identified the gene receptor-mediated endocytosis 8 (rme-8; human ortholog: DNAJC13) as a component of the proteostasis network. Accumulation of aggregation-prone proteins, such as amyloid-β 42 (Aβ), α-synuclein...
Swovick, Kyle Firsanov, Denis Welle, Kevin A Hryhorenko, Jennifer Wise, John P George, Craig Sformo, Todd L Seluanov, Andrei Gorbunova, Vera Ghaemmaghami, Sina
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Published in
Molecular & cellular proteomics : MCP
Cells continually degrade and replace damaged proteins. However, the high energetic demand of protein turnover generates reactive oxygen species (ROS) that compromise the long-term health of the proteome. Thus, the relationship between aging, protein turnover and energetic demand remains unclear. Here, we used a proteomic approach to measure rates ...
Noori, Ayush Mezlini, Aziz M. Hyman, Bradley T. Serrano-Pozo, Alberto Das, Sudeshna
Published in
Neurobiology of disease
Neurodegenerative disorders such as Alzheimer’s disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are defined by the accumulation of specific misfolded protein aggregates. However, the mechanisms by which each proteinopathy leads to neurodegeneration remain elusive. We hypot...
Preissler, Steffen Rato, Claudia Yan, Yahui Perera, Luke Czako, Aron Ron, David
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium release-dependent cellular processes. ER calcium depletion robustly activates the unfolded protein response (UPR). However, it is unclear how fluctuations in ER calcium impact org...
Stevens, Mckayla Howe, Chris Ray, Anne-Marie Washburn, Alex Chitre, Siddhi Sivinski, Jared Park, Yangshin Hoang, Quyen Q Chapman, Eli Johnson, Steven M
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Published in
Bioorganic & medicinal chemistry
In two previous studies, we identified compound 1 as a moderate GroEL/ES inhibitor with weak to moderate antibacterial activity against Gram-positive and Gram-negative bacteria including Bacillus subtilis, methicillin-resistant Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, and SM101 Escherichia coli (which has a compromised ...
Wiedmer, Petra Jung, Tobias Castro, José Pedro Pomatto, Laura C D Sun, Patrick Y Davies, Kelvin J A Grune, Tilman
Published in
Ageing research reviews
Sarcopenia represents a muscle-wasting syndrome characterized by progressive and generalized degenerative loss of skeletal muscle mass, quality, and strength occurring during normal aging. Sarcopenia patients are mainly suffering from the loss in muscle strength and are faced with mobility disorders reducing their quality of life and are, therefore...
Caldwell, Kim A Willicott, Corey W Caldwell, Guy A
Published in
Disease models & mechanisms
The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors. The nematode Caenorhabditis elegans has served as the experimental subject for multiple transformative discoveries that have redefined our understanding of biology for ∼60 years. More recent...