This research was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo/FAPESP (grant number 2004/12054–9), Rede Proteoma do Estado de São Paulo/FAPESP (grant number 2004/14846–0), and Conselho Nacional de Pesquisas/CNPq (grant number 308904/2014–1).
This work was supported by the EU in the framework of the Marie-Curie FP7 COFUND People Programme, through the award of an AgreenSkills fellowship, under grant agreement n° 267196. This work was also supported by INRA CI PHASE grant, by COST Action-EPICONCEPT-FA1201 and COST ActionSLAAM-BM1308. The high-resolution mass spectrometer was financed (SM...
Published in Journal of affective disorders
Although the search for reliable biomarkers of depression and/or treatment outcome is ongoing, the rapidly-expanding field of research along with promising new technologies may provide the foundation for identifying key factors which will ultimately help direct patients toward a quicker and more effective treatment for MDD.
Published in International journal of biological macromolecules
Fucoidans are complex sulfated polysaccharides that have a wide range of biological activities. Previously, we reported the various effects of Fucus vesiculosus fucoidan on tyrosinase and B16 melanoma cells. In this study, to identify fucoidan-targeted proteins in B16 melanoma cells, we performed a proteomics study and integrated enzyme kinetics. W...
Published in Free radical biology & medicine
Impaired bioenergetics and oxidative damage in the mitochondria are implicated in the etiology of temporal lobe epilepsy, and hyperacetylation of mitochondrial proteins has recently emerged as a critical negative regulator of mitochondrial functions. However, the roles of mitochondrial acetylation and activity of the primary mitochondrial deacetyla...
Published in International journal of biological macromolecules
Proteomics is the study of the functional aspect of all expressed proteins. Laudable progress has been made in context to protein profiles and interactions and this progress has been augmented with the help of the blueprint provided by the genomics field. Liver fibrosis is the starting point of various chronic liver diseases ultimately leading to c...
Published in Resuscitation
The depletion of serum kallistatin at admission to the ICU was associated with the poor neurological outcome of out-of-hospital cardiac arrest survivors.
Published in Ecotoxicology (London, England)
Ammonia is both a highly toxic environmental pollutant and the major nitrogenous waste produced by ammoniotelic teleosts. Although the acute toxic effects of ammonia have been widely studied in fish, the biochemical mechanisms of its toxicity have not been understood comprehensively. In this study, we performed comparative proteomic and metabolomic...
Diabetes is associated with numerous metabolic and vascular risk factors that contribute to a high rate of microvascular and macro-vascular disorders leading to mortality and morbidity from diabetic complications. In this case, the major cause of death in overall diabetic patients results from diabetic nephropathy (DN) or renal failure. The risk fa...
Published in Journal of the American Society of Nephrology : JASN
The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CCD) is highlighted by various water and electrolyte disorders that arise when the unique transport properties of these segments are disturbed. Despite this critical role, little is known about which proteins have a regulatory role in these cells and how these...
