Davydova, Erna Shimazu, Tadahiro Schuhmacher, Maren Kirstin Jakobsson, Magnus E. Willemen, Hanneke L. D. M. Liu, Tongri Moen, Anders Ho, Angela Y. Y. Małecki, Jędrzej Schroer, Lisa
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Published in
Nature Communications
Only very few enzymes are known to catalyze protein histidine methylation. Here, the authors show that METTL9 is responsible for most 1-methylhistidine modifications in mouse and human proteomes, and characterize METTL9′s substrate specificity and potential cellular functions.
Piras, Cristian Hale, Oliver J. Reynolds, Christopher K. Jones, A. K. Taylor, Nick Morris, Michael Cramer, Rainer
Published in
Scientific Reports
Growing interest in food quality and traceability by regulators as well as consumers demands advances in more rapid, versatile and cost-effective analytical methods. Milk, as most food matrices, is a heterogeneous mixture composed of metabolites, lipids and proteins. One of the major challenges is to have simultaneous, quantitative detection (profi...
Wu, Yuexin Cao, Yuyan Xu, Keren Zhu, Yue Qiao, Yuemei Wu, Yanjun Chen, Jianfeng Li, Chen Zeng, Rong Ge, Gaoxiang
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Published in
Cell Death & Disease
Liver cirrhosis remains major health problem. Despite the progress in diagnosis of asymptomatic early-stage cirrhosis, prognostic biomarkers are needed to identify cirrhotic patients at high risk developing advanced stage disease. Liver cirrhosis is the result of deregulated wound healing and is featured by aberrant extracellular matrix (ECM) remod...
Drastichova, Zdenka Rudajev, Vladimir Pallag, Gergely Novotny, Jiri
Published in
Biological Research
BackgroundEarly-life stress in the form of maternal separation can be associated with alterations in offspring neurodevelopment and brain functioning. Here, we aimed to investigate the potential impact of prolonged maternal separation on proteomic profiling of prefrontal cortex, hippocampus and cerebellum of juvenile and young adult rats. A special...
Lee, Sang-Yeop Yun, Sung Ho Lee, Hayoung Seo, Giwan Kim, Seung Il
Published in
Journal of Analytical Science and Technology
Delftia sp. K82 is a soil bacterium capable of utilizing monocyclic aromatic hydrocarbons, including aniline, as its sole carbon and nitrogen source. In this study, the genome analysis of Delftia sp. K82 was completed and the genome data (6117 protein-coding genes and 62 RNA genes) were utilized for proteomic and transcriptomic analysis of Delftia ...
Youssef, Lina Miranda, Jezid Blasco, Miquel Paules, Cristina Crovetto, Francesca Palomo, Marta Torramade-Moix, Sergi García-Calderó, Héctor Tura-Ceide, Olga Dantas, Ana Paula
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Published in
Scientific Reports
Preeclampsia is a pregnancy-specific multisystem disorder and a leading cause of maternal and perinatal morbidity and mortality. The exact pathogenesis of this multifactorial disease remains poorly defined. We applied proteomics analysis on maternal blood samples collected from 14 singleton pregnancies with early-onset severe preeclampsia and 6 unc...
Mörth, Charlott Sabaa, Amal Abu Freyhult, Eva Christersson, Christina Hashemi, Jamileh Hashemi, Nashmil Kamali-Moghaddam, Masood Molin, Daniel Höglund, Martin Eriksson, Anna
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Published in
Cardio-Oncology
BackgroundCardiovascular toxicity is a notorious complication of doxorubicin (DXR) therapy for diffuse large B-cell lymphoma (DLBCL). Although surveillance of well-known biological markers for cardiovascular disease (CVD) as NTproBNP and Troponins may be helpful, there are no established markers to monitor for evolving CVD during treatment. New pos...
Xu, Chen Luo, Shengchang Wei, Leixin Wu, Huiqiao Gu, Wei Zhou, Wenchao Sun, Baifeng Hu, Bo Zhou, Hongyu Liu, Yang
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Published in
BMC Medical Genomics
BackgroundDegeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis. However, neither have fully elucidated the exact mechanism of degeneration process. Since post-transcriptional regulation may affect gene expression b...
Bernasocchi, Tiziano El Tekle, Geniver Bolis, Marco Mutti, Azzurra Vallerga, Arianna Brandt, Laura P. Spriano, Filippo Svinkina, Tanya Zoma, Marita Ceserani, Valentina
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Published in
Nature Communications
Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render prostate tumor cells sensitive to antiandrogen therapy and that the presence of ERG promotes sensitivity...
Rörby, Emma Adolfsson, Jörgen Hultin, Erik Gustafsson, Thomas Lotfi, Kourosh Cammenga, Jörg Jönsson, Jan-Ingvar
Published in
Experimental Hematology & Oncology
BackgroundFms-related tyrosine kinase 3 (FLT3) receptor serves as a prognostic marker and therapeutic target in acute myeloid leukemia (AML). Approximately one-third of AML patients carry mutation in FLT3, associated with unfavourable prognosis and high relapse rate. The multitargeted kinase inhibitor midostaurin (PKC412) in combination with standa...