Santana, Monique F. M. Lira, Aécio L. A. Pinto, Raphael S. Minanni, Carlos A. Silva, Amanda R. M. Sawada, Maria I. B. A. C. Nakandakare, Edna R. Correa-Giannella, Maria L. C. Queiroz, Marcia S. Ronsein, Graziella E.
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Published in
Lipids in Health and Disease
Background and aimsDiabetic kidney disease (DKD) is associated with lipid derangements that worsen kidney function and enhance cardiovascular (CVD) risk. The management of dyslipidemia, hypertension and other traditional risk factors does not completely prevent CVD complications, bringing up the participation of nontraditional risk factors such as ...
Li, Siming Alfaro, Andrea C. Nguyen, Thao V. Young, Tim Lulijwa, Ronald
Published in
Metabolomics
BackgroundGreen-lipped mussels, commercially known as Greenshell™ mussels (Perna canaliculus Gmelin 1791), contribute > $300 million to New Zealand’s aquaculture exports. However, mortalities during summer months and potential pathogenic outbreaks threaten the industry. Thermal stress mechanisms and immunological responses to pathogen infections ne...
Mohd Nasri, Farah Amirah Zainal Ariffin, Shahrul Hisham Karsani, Saiful Anuar Megat Abdul Wahab, Rohaya
Published in
BMC Oral Health
BackgroundOrthodontically-induced root resorption is an iatrogenic effect and it cannot be examined regularly due to the harmful effects of sequential doses of radiation with more frequent radiography. This study aims to compare protein abundance (PA) of pre-treatment and during orthodontic treatment for root resorption and to determine potential e...
Drew, Kevin Lee, Chanjae Cox, Rachael M Dang, Vy Devitt, Caitlin C McWhite, Claire D Papoulas, Ophelia Huizar, Ryan L Marcotte, Edward M Wallingford, John B
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Published in
Developmental biology
Cell-type specific RNA-associated proteins are essential for development and homeostasis in animals. Despite a massive recent effort to systematically identify RNA-associated proteins, we currently have few comprehensive rosters of cell-type specific RNA-associated proteins in vertebrate tissues. Here, we demonstrate the feasibility of determining ...
Taylor, Erin M. Byrum, Stephanie D. Edmondson, Jacob L. Wardell, Christopher P. Griffin, Brittany G. Shalin, Sara C. Gokden, Murat Makhoul, Issam Tackett, Alan J. Rodriguez, Analiz
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Published in
Acta Neuropathologica Communications
Melanoma brain metastases (MBM) portend a grim prognosis and can occur in up to 40% of melanoma patients. Genomic characterization of brain metastases has been previously carried out to identify potential mutational drivers. However, to date a comprehensive multi-omics approach has yet to be used to analyze brain metastases. In this case report, we...
Grabsztunowicz, Magda Rokka, Anne Farooq, Irum Aro, Eva-Mari Mulo, Paula
Published in
BMC Plant Biology
BackgroundNon-photosynthetic plastids of plants are known to be involved in a range of metabolic and biosynthetic reactions, even if they have been difficult to study due to their small size and lack of color. The morphology of root plastids is heterogeneous and also the plastid size, density and subcellular distribution varies depending on the cel...
Schuster-Little, Naviya Madera, Sergio Whelan, Rebecca
Published in
Analytical and bioanalytical chemistry
Ovarian cancer diagnosis and the monitoring of ovarian cancer patients currently rely on the detection of the glycoprotein CA125 through a double-determinant immunoassay. This immunoassay may not provide accurate reporting of CA125 amounts in serum samples if the antibodies fail to detect all proteoforms (false negative results) or because of antib...
Kodidela, Sunitha Wang, Yujie Patters, Benjamin J Gong, Yuqing Sinha, Namita Ranjit, Sabina Gerth, Kelli Haque, Sanjana Cory, Theodore McArthur, Carole
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Published in
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Abuse of alcohol and tobacco could exacerbate HIV pathogenesis by transferring materials through exosomes (small nanovesicles). Exosomes present a stable and accessible source of information concerning the health and/or disease status of patients, which can provide diagnostic and prognostic biomarkers for myriad conditions. Therefore, we aimed to s...
Kline, Rachel A Wishart, Thomas M Mills, Kevin Heywood, Wendy E
Published in
Biochimica et biophysica acta. Molecular basis of disease
The Neuronal Ceroid Lipofuscinoses are a group of severe and progressive neurodegenerative disorders, which generally present during childhood. With new treatments emerging on the horizon, there is a growing need to understand the specific disease mechanisms as well as identify prospective biomarkers for use to stratify patients and monitor treatme...
Jeong, Heesoo Vacanti, Nathaniel M.
Published in
Nutrition & Metabolism
The kinetics and localization of the reactions of metabolism are coordinated by the enzymes that catalyze them. These enzymes are controlled via a myriad of mechanisms including inhibition/activation by metabolites, compartmentalization, thermodynamics, and nutrient sensing-based transcriptional or post-translational regulation; all of which are in...
