Pelaz, Sara G Flores-Hernández, Raquel Vujic, Tatjana Schvartz, Domitille Álvarez-Vázquez, Andrea Ding, Yuxin García-Vicente, Laura Belloso, Aitana Talaverón, Rocío Sánchez, Jean-Charles
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Published in
Translational research : the journal of laboratory and clinical medicine
Glioblastoma (GBM) is the most frequent and aggressive primary brain cancer. The Src inhibitor, TAT-Cx43266-283, exerts antitumor effects in in vitro and in vivo models of GBM. Because addressing the mechanism of action is essential to translate these results to a clinical setting, in this study we carried out an unbiased proteomic approach. Data-i...
Di Stefano, Julia Garcia-Pupo, Laura Di Marco, Federica Motaln, Helena Govaerts, Jonas Van Breedam, Elise Mateiu, Ligia Monica Van Calster, Siebe Ricciardi, Leonardo Quarta, Alessandra
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Published in
Brain, behavior, and immunity
induced-pluripotent stem cell (iPSC)-derived neurospheroid (NSPH) models are an emerging in vitro toolkit to study the influence of inflammatory triggers on neurodegeneration and repair in a 3D neural environment. In contrast to their human counterpart, the absence of murine iPSC-derived NSPHs for profound characterisation and validation studies is...
Cheng, Yuemei Liang, Xiaolei Bi, Xuehan Liu, Chang Yang, Yongxiu
Published in
Biochemical genetics
In developed countries, endometrial cancer (EC) is the most prevalent gynecological cancer. ATP5F1D is a subunit of ATP synthase, as well as an important component of the mitochondrial electron transport chain (ETC). ETC plays a compelling role in carcinogenesis. To date, little is known about the role of ATP5F1D in EC. We undertook data-independen...
Gangfuß, Andrea Rating, Philipp Ferreira, Tomas Hentschel, Andreas Marina, Adela Della Kölbel, Heike Sickmann, Albert Abicht, Angela Kraft, Florian Ruck, Tobias
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Peer reviewed: True / BACKGROUND: The NADH dehydrogenase [ubiquinone] iron-sulfur protein 6 (NDUFS6) gene encodes for an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Bi-allelic NDUFS6 variants have been linked with a severe disorder mostly reported as a lethal infantile mitochondrial disease (LMI...
Bhutada, Sumit Hoyle, Anna Piuzzi, Nicolas S Apte, Suneel S
Published in
Osteoarthritis and cartilage
Proteolytic cartilage extracellular matrix breakdown is a major mechanism of articular cartilage loss in osteoarthritis (OA) pathogenesis. We sought to determine the overlap of proteolytic peptides in matched knee OA cartilage and synovial fluid on a proteome-wide scale to increase the prospective biomarker repertoire and to attribute proteolytic c...
Bontemps, Alexandra Bertrand, Benoit Bray, Fabrice Hédouin, Valéry Rolando, Christian
Proteomics is a powerful tool for studying the proteins present in biological tissues. This method is attracting growing interest in forensic anthropology. Currently, the post-mortem interval is difficult to determine due to the complexity of biochemical processes during body decomposition, especially if the remains are only bones and teeth. In col...
Xie, Yongyan Fang, Cong Lu, Longhui Wang, Jingjing Wu, Li Wang, Shuaikang Guo, Qiujing Yan, Wenyan Wei, Jinghua Duan, Feipeng
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Published in
Journal of ethnopharmacology
The dried rattan stem of Tinospora sinensis (Lour.) Merr. is valued for its efficacy of clearing heat and removing toxicity, calming and soothing the nerves. It is widely used in Tibetan medicine for the treatment of rheumatic and aging diseases. Studies have confirmed its anti-inflammatory and ameliorating effects on Alzheimer's disease; however, ...
Bjørnstad, Ole Vidhammer Carrasco, Manuel Finne, Kenneth Ardawatia, Vandana Winge, Ingeborg Askeland, Cecilie Arnes, Jarle B Knutsvik, Gøril Kleftogiannis, Dimitrios Paulo, Joao A
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Published in
EBioMedicine
Presence of nerves in tumours, by axonogenesis and neurogenesis, is gaining increased attention for its impact on cancer initiation and development, and the new field of cancer neuroscience is emerging. A recent study in prostate cancer suggested that the tumour microenvironment may influence cancer progression by recruitment of Doublecortin (DCX)-...
Diaz, Rocio Vacik Munsch, Gaelle Iglesias, Maria Jesus Robles, Alejandro Pallares Ibrahim-Kosta, Manal Nourse, Jamie Khan, Essak Castoldi, Elisabetta Saut, Noemie Boland, Anne
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BACKGROUND: The thrombin generation assay (TGA) evaluates the potential of plasma to generate thrombin over time, providing a global picture of an individual's hemostatic balance. OBJECTIVES: This study aimed to identify novel biological determinants of thrombin generation using a multi-omics approach. METHODS: Associations between TGA parameters a...
Polacco, Benjamin Lobingier, Braden Blythe, Emily Abreu, Nohely Khare, Prachi Howard, Matthew Gonzalez-Hernandez, Alberto Xu, Jiewei Li, Qiongyu Novy, Brandon
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The μ-opioid receptor (μOR) represents an important target of therapeutic and abused drugs. So far, most understanding of μOR activity has focused on a subset of known signal transducers and regulatory molecules. Yet μOR signaling is coordinated by additional proteins in the interaction network of the activated receptor, which have largely remained...
