Pei, J. Schuldt, M. Nagyova, E. Gu, Z. el Bouhaddani, S. Yiangou, L. Jansen, M. Calis, J. J. A. Dorsch, L. M. Blok, C. Snijders
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Published in
Clinical Epigenetics
BackgroundHypertrophic cardiomyopathy (HCM) is the most common genetic disease of the cardiac muscle, frequently caused by mutations in MYBPC3. However, little is known about the upstream pathways and key regulators causing the disease. Therefore, we employed a multi-omics approach to study the pathomechanisms underlying HCM comparing patient heart...
Uzozie, Anuli C. Ergin, Enes K. Rolf, Nina Tsui, Janice Lorentzian, Amanda Weng, Samuel S. H. Nierves, Lorenz Smith, Theodore G. Lim, C. James Maxwell, Christopher A.
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Published in
Journal of Experimental & Clinical Cancer Research
BackgroundMurine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein maturation by proteolytic processing in 11 pediatric B- and T- cell ALL patients and 19 corresponding xenograf...
Wang, Wenxia Du, Jie Chen, Liming Zeng, Yongjun Tan, Xueming Shi, Qinghua Pan, Xiaohua Wu, Ziming Zeng, Yanhua
Published in
BMC Genomics
BackgroundLow temperature (LT) often occurs at the seedling stage in the early rice-growing season, especially for direct seeded early-season indica rice, and using flooding irrigation can mitigate LT damage in rice seedlings. The molecular mechanism by which flooding mitigates the damage induced by LT stress has not been fully elucidated. Thus, LT...
Chen, Lingling Carlton, Morgan Chen, Xiaodan Kaur, Navdeep Ryan, Hollie Parker, Tony J Lin, Zhengmei Xiao, Yin Zhou, Yinghong
Published in
Stem Cell Research & Therapy
BackgroundGrowing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors. Fibronectin (FN), fibroblast growth factor 2 (FGF2), and bone morphogenetic protein 4 (BMP4) are the key players in the regulation of stemness and lineage com...
Askarian, Fatemeh Uchiyama, Satoshi Masson, Helen Sørensen, Henrik Vinther Golten, Ole Bunæs, Anne Cathrine Mekasha, Sophanit Røhr, Åsmund Kjendseth Kommedal, Eirik Ludviksen, Judith Anita
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The recently discovered lytic polysaccharide monooxygenases (LPMOs), which cleave polysaccharides by oxidation, have been associated with bacterial virulence, but supporting functional data is scarce. Here we show that CbpD, the LPMO of Pseudomonas aeruginosa, is a chitin-oxidizing virulence factor that promotes survival of the bacterium in human b...
Pech, Sabine Rehberg, Markus Janke, Robert Benndorf, Dirk Genzel, Yvonne Muth, Thilo Sickmann, Albert Rapp, Erdmann Reichl, Udo
Published in
Applied Microbiology and Biotechnology
Abstract Adaptations of animal cells to growth in suspension culture concern in particular viral vaccine production, where very specific aspects of virus-host cell interaction need to be taken into account to achieve high cell specific yields and overall process productivity. So far, the complexity of alterations on the metabolism, enzyme, and prot...
Alpha-Bazin, Béatrice Gorlas, Aurore Lagorce, Arnaud Joulié, Damien Boyer, Jean-Baptiste Dutertre, Murielle Gaillard, Jean-Charles Lopes, Anne Zivanovic, Yvan Dedieu, Alain
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Thermococcus gammatolerans EJ3 is an extremophile archaeon which was revealed as one of the most radioresistant organisms known on Earth, withstanding up to 30 kGy gamma-ray radiations. While its theoretical proteome is rather small, T. gammatolerans may enhance its toolbox by post-translational modification of its proteins. Here, we explored its e...
Navajas, Rosana Corrales, Fernando Paradela, Alberto
Published in
Clinical Proteomics
BackgroundQuantitative proteomics is an invaluable tool in biomedicine for the massive comparative analysis of protein component of complex biological samples. In the last two decades, this technique has been used to describe proteins potentially involved in the pathophysiological mechanisms of preeclampsia as well as to identify protein biomarkers...
Lin, Ping Bai, Hui-ru He, Ling Huang, Qiu-xiang Zeng, Qin-han Pan, Yuan-zhi Jiang, Bei-bei Zhang, Fan Zhang, Lei Liu, Qing-Lin
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Published in
BMC Genomics
BackgroundLow-temperature severely affects the growth and development of chrysanthemum which is one kind of ornamental plant well-known and widely used in the world. Lysine crotonylation is a recently identified post-translational modification (PTM) with multiple cellular functions. However, lysine crotonylation under low-temperature stress has not...
Lathwal, Anjali Kumar, Rajesh Raghava, Gajendra P S
Published in
Computers in biology and medicine
Globally, ~20% of cancer malignancies are associated with virus infections. Lung cancer is the most prevalent cancer and has a 10% 5-year survival rate when diagnosed at stage IV. Cancer vaccines and oncolytic immunotherapy are promising treatment strategies for better clinical outcomes in advanced-stage cancer patients. Here, we used a reverse vac...
