Cirne, Filipe Aghel, Nazanin Petropoulos, Jo-Anne Klotz, Laurence Lenihan, Daniel J Saad, Fred Pinthus, Jehonathan Leong, Darryl P
Published in
European heart journal. Cardiovascular pharmacotherapy
The aim of this study was to determine whether gonadotropin-releasing hormone (GnRH) antagonists (an emerging class of drugs to suppress testosterone synthesis in the treatment of prostate cancer) cause less adverse cardiovascular events than the more commonly use GnRH agonists. We conducted a systematic review to identify all randomized, controlle...
Ge, Fan Huo, Zhenyu Liu, Yeling Du, Xiaoqin Wang, Rui Lin, Weiyi Wang, Runchen Chen, Jiana Lu, Yi Wen, Yaokai
...
Published in
Comprehensive psychiatry
Observational studies analyzing the risk of prostate cancer in schizophrenia patients have generated mixed results. We performed a meta-analysis and a Mendelian randomization (MR) analysis to evaluate the relationship and causality between schizophrenia and the risk of prostate cancer. A comprehensive and systematic search of cohort studies was con...
Pacheco, Mariana Brütt Camilo, Vânia Henrique, Rui Jerónimo, Carmen
Published in
Epigenetics
Epigenome editing consists of fusing a predesigned DNA recognition unit to the catalytic domain of a chromatin modifying enzyme leading to the introduction or removal of an epigenetic mark at a specific locus. These platforms enabled the study of the mechanisms and roles of epigenetic changes in several research domains such as those addressing pat...
Levenson, Anait S
Published in
Seminars in cancer biology
Dietary bioactive polyphenols that demonstrate beneficial biological functions including antioxidant, anti-inflammatory, and anticancer activity hold immense promise as effective and safe chemopreventive and chemosensitizing natural anticancer agents. The underlying molecular mechanisms of polyphenols' multiple effects are complex and these molecul...
Tewari, Devesh Patni, Pooja Bishayee, Anusha Sah, Archana N Bishayee, Anupam
Published in
Seminars in cancer biology
The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of rapamycin (mTOR) represent two vital intracellular signaling pathways, which are associated with various aspects of cellular functions. These functions play vital roles in quiescence, survival, and growth in normal physiological circumstances as well as in various pathological...
Agarwal, Vibhore Yadav, Sher Singh Kumar, Sanjay Mehta, Nishkarsh Talwar, Gagandeep Qadri, Javed Sarwar, Saba
Published in
Urologia
To our knowledge, EVs (extracellular vesicles) are heterogenous encapsulated nanoparticles generated by the biological cells. EVs can be found in blood, urine and tissue of origin. They contain DNAs, RNAs, proteins specific to the cell of origin. It has been found that in PCa, increase in number of EVs can modulate phenotype and function of the rec...
Anderson, Ashley B Grazal, Clare Wedin, Rikard Kuo, Claire Chen, Yongmei Christensen, Bryce R Cullen, Jennifer Forsberg, Jonathan A
Published in
BMC cancer
Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate survival duration after treatment for skeletal-related events (SREs) (symptomatic bone metastasis, including impending or actual pathologic fract...
Tao, Yan Liu, Shanhui Lu, Jianzhong Fu, Shengjun Li, Lanlan Zhang, Jing Wang, Zhiping Hong, Mei
Published in
BMC urology
Although FOXO3a can inhibit the cell proliferation of prostate cancer, its relationship with reactive oxygen species (ROS) in prostate cancer (PCa) has not been reported. We analyzed the correlation between the expression of FOXO3a and the antioxidant enzyme catalase in prostate cancer with the TCGA and GEPIA databases. We also constructed a PPI ne...
Scholman, Renzo (author)
Even if a Multi-modal Multi-Objective Evolutionary Algorithm (MMOEA) is designed to find all locally optimal approximation sets of a Multi-modal Multi-objective Optimization Problem (MMOP), there is a risk that the found approximation sets are not smoothly navigable because the solutions belong to various niches, which reduces the insight for decis...
Jouberton, Elodie Voissiere, Aurélien Penault-Llorca, Frédérique Cachin, Florent Miot-Noirault, Elisabeth
An increasing number of studies concerning solid cancers, including prostate cancer, are tending to demonstrate the predominant role of the interactions of tumor cells with their microenvironment, and underlining the relevance of therapeutic approaches co-targeting these two components. Artificial in vitro 3D culture models, such as spheroids, are ...
