van Son, Marieke Peters, Max Moerland, Marinus van de Pol, Sandrine Eppinga, Wietse Lagendijk, Jan van der Voort van Zyp, Jochem
Published in
Clinical and translational radiation oncology
Local re-treatment of radiorecurrent prostate cancer is potentially curative. However, the increased risk of severe toxicity may outweigh the opportunity of cancer control. This study aims to evaluate treatment-related toxicity from ultrafocal salvage high-dose-rate brachytherapy (HDR-BT) and to investigate potential risk factors. Toxicity data fro...
Sutton, E Lane, J A Davis, M Walsh, E I Neal, D E Hamdy, F C Mason, M Staffurth, J Martin, R M Metcalfe, C
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Published in
Cancer causes & control : CCC
To investigate men's experiences of receiving external-beam radiotherapy (EBRT) with neoadjuvant Androgen Deprivation Therapy (ADT) for localized prostate cancer (LPCa) in the ProtecT trial. A longitudinal qualitative interview study was embedded in the ProtecT RCT. Sixteen men with clinically LPCa who underwent EBRT in ProtecT were purposively sam...
Rinne, Sara S. Abouzayed, Ayman Gagnon, Katherine Tolmachev, Vladimir Orlova, Anna
Published in
Scientific Reports
Molecular imaging of the gastrin-releasing peptide receptor (GRPR) could improve patient management in prostate cancer. This study aimed to produce gallium-66 (T½ = 9.5 h) suitable for radiolabeling, and investigate the imaging properties of gallium-66 labeled GRPR-antagonist NOTA-PEG2-RM26 for later-time point PET-imaging of GRPR expression. Galli...
Makarov, Danil V. Feuer, Zachary Ciprut, Shannon Lopez, Natalia Martinez Fagerlin, Angela Shedlin, Michele Gold, Heather T. Li, Huilin Lynch, Gina Warren, Rueben
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Published in
Trials
BackgroundBlack men are disproportionately affected by prostate cancer, the most common non-cutaneous malignancy among men in the USA. The United States Preventive Services Task Force (USPSTF) encourages prostate-specific antigen (PSA) testing decisions to be based on shared decision-making (SDM) clinician professional judgment, and patient prefere...
Rowe, Lindsay S. Harmon, Stephanie Horn, Adam Shankavaram, Uma Roy, Soumyajit Ning, Holly Lindenberg, Liza Mena, Esther Citrin, Deborah E. Choyke, Peter
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Published in
Radiation Oncology
BackgroundProstate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate cancer (PCa). In this study, we aimed to outline patterns of failure in a group of post-prostatectomy patients who received adjuvant o...
Briggs, Erica M. McKerrow, Wilson Mita, Paolo Boeke, Jef D. Logan, Susan K. Fenyö, David
Published in
Mobile DNA
BackgroundLong INterspersed Element-1 (LINE-1) is an autonomous retroelement able to “copy-and-paste” itself into new loci of the host genome through a process called retrotransposition. The LINE-1 bicistronic mRNA codes for two proteins, ORF1p, a nucleic acid chaperone, and ORF2p, a protein with endonuclease and reverse transcriptase activity. Bot...
Jochumsen, Mads Ryø Sörensen, Jens Tolbod, Lars Poulsen Pedersen, Bodil Ginnerup Frøkiær, Jørgen Borre, Michael Bouchelouche, Kirsten
Published in
EJNMMI Research
BackgroundBoth prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressiveness. The aim of the present study was to evaluate the potential synergistic benefit of combining the two physiologic parameters fo...
Ploussard, Guillaume Fossati, Nicola Wiegel, Thomas D'Amico, Anthony Hofman, Michael S Gillessen, Silke Mottet, Nicolas Joniau, Steven Spratt, Daniel E
Published in
European urology oncology
The prognosis and optimal management of pN0/pN1 patients with persistently elevated prostate-specific antigen (PSA) 6-8 wk after radical prostatectomy (RP) remain unclear. To perform a systematic review of oncologic outcomes and effectiveness of salvage therapies in men with a detectable PSA level after RP. A systematic review was performed in May ...
Williams, Sophie Therese El Badri, Salma Hussain, Syed Anwer
Published in
British Journal of Cancer
Background Active cancer, immunosuppressive treatments and immunotherapies have been reported to increase cancer patients’ risk of developing severe COVID-19 infection. For patients and clinicians, treatment risk must be weighed against disease progression. Methods This retrospective case series surveys urological cancer patients who made informed ...
Ajami, Tarek Durruty, Jaime Mercader, Claudia Rodriguez, Leonardo Ribal, Maria J. Alcaraz, Antonio Vilaseca, Antoni
Published in
BMC Urology
BackgroundIn May 2012 the US Preventive Task Force issued a ‘D’ recommendation against routine PSA-based early detection of prostate cancer. This recommendation was implemented progressively in our health system. The aim of this study is to define its impact on prostate cancer staging at a tertiary care institution.MethodsA retrospective analysis w...
