Weidemann, Sören A. Sauer, Charlotte Luebke, Andreas M. Möller-Koop, Christina Steurer, Stefan Hube-Magg, Claudia Büscheck, Franziska Höflmayer, Doris Tsourlakis, Maria Christina Clauditz, Till S.
...
Published in
BMC Cancer
BackgroundProtein tyrosine phosphatase non-receptor 12 (PTPN12) is ubiquitously tyrosine phosphatase with tumor suppressive properties.MethodsPTPN12 expression was analyzed by immunohistochemistry on a tissue microarray with 13,660 clinical prostate cancer specimens.ResultsPTPN12 staining was typically absent or weak in normal prostatic epithelium ...
Lu, Jiacheng Li, Hailin Chen, Zhengxin Fan, Ligang Feng, Shuang Cai, Xiaomin Wang, Huibo
Published in
Cancer Cell International
BackgroundTumor-infiltrating immune cells (TIICs) are highly relevant to clinical outcome of glioma. However, previous studies cannot account for the diverse functions that make up the immune response in malignant transformation (MT) from low-grade glioma (LGG) to high-grade glioma (HGG).MethodsTranscriptome level, genomic profiles and its relation...
Zhang, Chenghao Ren, Xiaolei He, Jieyu Wang, Wanchun Tu, Chao Li, Zhihong
Published in
Cancer Cell International
BackgroundCancer has been a worldwide health problem with a high risk of morbidity and mortality, however ideal biomarkers for effective screening and diagnosis of cancer patients are still lacking. Small nucleolar RNA host gene 16 (SNHG16) is newly identified lncRNA with abnormal expression in several human malignancies. However, its prognostic va...
Liu, Haiyan Wu, Yan Wang, Shunye Jiang, Jie Zhang, Chenlu Jiang, Yijing Wang, Xingfeng Hong, Lewen Huang, Hongming
Published in
BMC Cancer
BackgroundWe aimed to investigate the correlation of Circ-SMARCA5 with disease severity and prognosis in multiple myeloma (MM), and its underlying mechanisms in regulating cell proliferation and apoptosis.MethodsBone marrow samples from 105 MM patients and 36 healthy controls were collected for Circ-SMARCA5 expression measurement. And the correlati...
Wu, Xiaoli Lin, Han Li, Shaotang
Published in
BMC Gastroenterology
BackgroundWhether the prognoses of different pathological subtypes of colorectal cancer (CRC) at different stages are distinct is unclear.MethodsWe extracted data on all cases of CRC from the Surveillance, Epidemiology, and End Results database between 2004 and 2015. The incidence of different pathological subtypes, clinical characteristics, and fi...
Zhang, Zhanglin Chen, Zhiwei Jiang, Mei Liu, Shuyuan Guo, Yang Wan, Lagen Li, Fei
Published in
BMC Cancer
BackgroundAlthough extensive use of tyrosine kinase inhibitors has resulted in high and durable response rate and prolonged survival time in patients with BCR-ABL1 positive chronic myeloid leukemia (CML) and acute leukemia, relapse and drug resistance still remain big challenges for clinicians. Monitoring the expression of BCR-ABL1 fusion gene and ...
Ye, Shu-Biao Cheng, Yi-Kan Zhang, Lin Wang, Xue-Ping Wang, Lei Lan, Ping
Published in
BMC Cancer
BackgroundPrognostic assessment is crucial for optimal treatment. The aim of our study was to investigate the potential impact of estrogen receptor-α (ER-α) and progesterone receptor (PR) on the prognosis of colorectal cancer (CRC) patients who received curative resection.MethodsRetrospective evaluation of two independent cohorts of CRC patients ma...
Padeganeh, Abbas Song, Joo Aoun, Patricia Mei, Matthew Ali, Haris
Micale, Mark A
Plasma cell myeloma (PCM) is a complex and genetically heterogenous hematological malignancy involving clonal proliferation of plasma cells in bone marrow. It is the third most common hematolymphoid malignancy in the United States and primarily affects elderly people with a median onset age of 69 years and a survival duration ranging from a few mon...
Klatte, Tobias Gallagher, Kevin M. Afferi, Luca Volpe, Alessandro Kroeger, Nils Ribback, Silvia McNeill, Alan Riddick, Antony C. P. Armitage, James N. ‘Aho, Tevita F.
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Published in
BMC Medicine
BackgroundThe current World Health Organization classification recognises 12 major subtypes of renal cell carcinoma (RCC). Although these subtypes differ on molecular and clinical levels, they are generally managed as the same disease, simply because they occur in the same organ. Specifically, there is a paucity of tools to risk-stratify patients w...
