Xiong, Hui Luo, Miao Ju, Yankun Zhao, Zhongqiu Zhang, Man Xu, Ran Ren, Yongshen Yang, Guangzhong Mei, Zhinan
Published in
Journal of ethnopharmacology
The stems of Entada phaseoloides (L.) Merr commonly named "Guo-gang-long", is a traditional Chinese folk medicine that has been used clinically in China for the treatment of arthritis. Our previous study described that triterpene saponins isolated from "Guo-gang-long" could inhibit the inflammatory response. However, the potential mechanism of "Guo...
Ma, Qingyi Dasgupta, Chiranjib Shen, Guofang Li, Yong Zhang, Lubo
Published in
Journal of Neuroinflammation
BackgroundNeonatal hypoxic-ischemic (HI) brain injury is a leading cause of acute mortality and chronic disability in newborns. Our previous studies demonstrated that HI insult significantly increased microRNA-210 (miR-210) in the brain of rat pups and inhibition of brain endogenous miR-210 by its inhibitor (LNA) provided neuroprotective effect in ...
Kouli, Antonina Camacho, Marta Allinson, Kieren Williams-Gray, Caroline H.
Published in
Acta Neuropathologica Communications
Parkinson’s disease dementia is neuropathologically characterized by aggregates of α-synuclein (Lewy bodies) in limbic and neocortical areas of the brain with additional involvement of Alzheimer’s disease-type pathology. Whilst immune activation is well-described in Parkinson’s disease (PD), how it links to protein aggregation and its role in PD de...
Souza, Clarissa Leal Silva e Oliveira, Hellen Braga Martins Santos Júnior, Manoel N. Silva, Mariângela de Oliveira Coqueiro, Igor Lopes Silva, Ícaro Bonyek Santos da Campos, Guilherme Barreto Silva, Robson Amaro Augusto da Soares, Telma de Jesus Oliveira, Márcio Vasconcelos de
...
ABSTRACT Objective: Staphylococcus aureus infections remain associated with considerable morbidity and mortality in both hospitals and the community. There is little information regarding the role of ovarian hormones in infections caused by S. aureus. The aim of this study was to evaluate the effects of ovariectomy in the immune response induced by...
Lee, Jung-Hyun Eberhardt, Martin Blume, Katja Vera, Julio Baur, Andreas S
Published in
EBioMedicine
Before and after surgery melanoma patients harbor elevated levels of extracellular vesicles in plasma (pEV), suppressing tumor cell activity. However, due to technical reasons and lack of cell-specific biomarkers, their cellular origin remains obscure. We mimicked the interaction of tumor cells with liver cells and PBMC in vitro, and compared newly...
Saleem, Ammara Saleem, Mohammad Akhtar, Muhammad Furqan Shahzad, Muhammad Jahan, Shah
Published in
Inflammopharmacology
Polystichum braunii (Spenn.) Fée is a traditional remedy for rheumatoid arthritis, a chronic inflammatory disorder of polygenetic origin. The current project was intended to demonstrate the role of inflammatory and oxidative stress biomarkers in the anti-arthritic activity of the P. braunii extracts. Methanolic and aqueous extracts of the plant roo...
Carty, Michael Guy, Coralie Bowie, Andrew G
Published in
Biochemical pharmacology
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to viral infections critically depend on the initial activation of PRRs by viruses, mainly by viral DNA and RNA. The signalling pathway...
Wang, Yan Liao, Mengling Zhang, Yu Deng, Fei Luo, Jing Wang, Nuoyan Liu, Min Ao, Lin Fang, Qimei Wang, Qingchun
...
Published in
European journal of pharmacology
Glucocorticoids are commonly used in clinic, but the immunosuppression seriously hinders their usage. Herein, immunomodulatory effect of artesunate (AS) on hydrocortisone (HC)-induced immunosuppression was investigated. HC-induced immunosuppression mice (HC mice) were established by intramuscular administration with HC (20 mg/kg) once a day for 5 c...
Kouli, Antonina Camacho, Marta Allinson, Kieren Williams-Gray, Caroline H.
Abstract: Parkinson’s disease dementia is neuropathologically characterized by aggregates of α-synuclein (Lewy bodies) in limbic and neocortical areas of the brain with additional involvement of Alzheimer’s disease-type pathology. Whilst immune activation is well-described in Parkinson’s disease (PD), how it links to protein aggregation and its rol...
Yuan, Yazhi Su, Mei Liu, Jing Lou, Yajing Xia, Yufeng Zhou, Bo
Published in
Naunyn-Schmiedeberg's archives of pharmacology
The study was undertaken to evaluate the safety of vitacamphorae (VCP) injection in Sprague-Dawley (SD) rats. Rats were intravenously administered with VCP at the doses of 0, 5, 15, and 50 mg/kg/day (equivalent to 0, 5, 15, and 50 times the clinical equivalent dose) for 4 weeks, respectively. In addition, we also tested oxidative stress-related par...
