El-Mikkawy, Dalia M. E. EL-Sadek, Maha A. EL-Badawy, Mohja A. Samaha, Dalia
Published in
Egyptian Rheumatology and Rehabilitation
BackgroundObesity is an important feature of metabolic syndrome, and the link between them has been attributed to the state of chronic inflammatory process.The purpose of the study is to investigate the relation of circulating level of IL-6 as an inflammatory cytokine to body mass index and lipid profile in adults with overweight and obesity.Method...
Spiesshoefer, Jens Henke, Carolin Kabitz, Hans Joachim Nofer, Jerzy Roch Mohr, Michael Evers, Georg Strecker, Jan-Kolia Brix, Tobias Randerath, Winfried Johannes Herkenrath, Simon
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Published in
Respiration
Background: In lung transplant recipients (LTRs), restrictive ventilation disorder may be present due to respiratory muscle dysfunction that may reduce exercise capacity. This might be mediated by pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Objective: We investigated lung respiratory muscle function ...
Chen, Shu Wang, Qian Han, Bing Wu, Jia Liu, Ding-kun Zou, Jun-dong Wang, Mi Liu, Zhi-hui
Published in
Journal of Zhejiang University-SCIENCE B
Combined radiation-wound injury (CRWI) is characterized by blood vessel damage and pro-inflammatory cytokine deficiency. Studies have identified that the direct application of leptin plays a significant role in angiogenesis and inflammation. We established a sustained and stable leptin expression system to study the mechanism. A lentivirus method w...
Lange-Consiglio, Anna Romele, Pietro Magatti, Marta Silini, Antonietta Idda, Antonella Martino, Nicola Antonio Cremonesi, Fausto Parolini, Ornella
Published in
Stem Cell Research & Therapy
BackgroundEquine amniotic mesenchymal stromal cells (AMSCs) and their conditioned medium (CM) were evaluated for their ability to inhibit in vitro proliferation of peripheral blood mononuclear cells (PBMCs) with and without priming. Additionally, AMSC immunogenicity was assessed by expression of MHCI and MHCII and their ability to counteract the in...
Altowyan, Mezna Saleh Barakat, Assem Al-Majid, Abdullah Mohammed Al-Ghulikah, H.A.
Published in
Saudi Journal of Biological Sciences
To design and discover a new compound can used as a COX with TNF-α and IL-6 inhibitors is highly challenge. A series of spiroindolone-bearing benzofuran moieties were resynthesized from the chalcone-based benzo[ b ]furan with substituted isatin, and amino acids. The requisite spiroindolone analogues were tested for their potential inhibitory activi...
Chen, Jiezhong Vitetta, Luis
Published in
Immune Network
An excessive hyperinflammatory response-caused septic shock is a major medical problem that is associated with pathogenic bacterial infections leading to high mortality rates. The intestinal microbiota and the associated elaborated metabolites such as short chain fatty acid butyrate have been shown to relieve pathogenic bacterial-caused acute infla...
Salaverry, Luciana S Parrado, Andrea C Mangone, Franco M Dobrecky, Cecilia B Flor, Sabrina A Lombardo, Tomás Sotelo, Agustina D Saccodossi, Natalia Rugna, Ana Z Blanco, Guillermo
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Published in
Journal of ethnopharmacology
Extracts of Smilax campestris Griseb (Smilacaceae) have been employed in the treatment of several inflammatory diseases as a traditional herbal medicine. However, the cellular and molecular mechanisms involved in the observed effects remain elusive. Macrophages are known to play a central role in inflammatory responses. These cells are activated in...
Alicka, Michalina Kornicka-Garbowska, Katarzyna Kucharczyk, Katarzyna Kępska, Martyna Rӧcken, Michael Marycz, Krzysztof
Published in
Stem Cell Research & Therapy
BackgroundProgressive loss of cell functionality caused by an age-related impairment in cell metabolism concerns not only mature specialized cells but also its progenitors, which significantly reduces their regenerative potential. Adipose-derived stem cells (ASCs) are most commonly used in veterinary medicine as an alternative treatment option in l...
Qiao, Yanhong Jiao, Haiyan Wang, Feng Niu, Huimin
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear. The present study was performed to investig...
Wang, Jing Lai, Simin Li, Guodong Zhou, Ting Wang, Biao Cao, Fang Chen, Teng Zhang, Xia Chen, Yanjiong
Published in
Brain, behavior, and immunity
We previously demonstrated that the dopamine D3 receptor (D3R) inhibitor, NGB2904, increases susceptibility to depressive-like symptoms, elevates pro-inflammatory cytokine expression, and alters brain-derived neurotrophic factor (BDNF) levels in mesolimbic dopaminergic regions, including the medial prefrontal cortex (mPFC), nucleus accumbens (NAc),...
