Herlambang, Fitri, Amelia Dwi Syauqy, Ahmad Yuwono, Puspasari, Anggelia Enis, Rina Nofri Faried, Ahmad
Published in
BMC Research Notes
ObjectiveCalcitonin receptor-like receptor (CRLR) regulates vasoconstriction and dilatation; the expression increases during hypoxia via activation of hypoxia response element (HRE) in CRLR gene promoter region. Variant in HRE, as well short tandem repeat (STR) variants near HRE in CRLR alters the gene expression. This study focused on a case–contr...
von Hellens, Hetti Keski-Nisula, Leea Sahlman, Heidi
Published in
BMC Pregnancy and Childbirth
BackgroundThe maternal use of paracetamol during pregnancy has been associated with the development of preeclampsia. This study aims to clarify whether the connection is causal or whether it is due to reverse causation.MethodsThis study is a continuation of the retrospective case cohort study examining 2,508 pregnant women using a variety of drugs ...
Lang, Xiao Liu, Wei Hou, Yanyan Zhao, Wenxia Yang, Xingyu Chen, Lan Yan, Qi Cheng, Weiwei
Published in
BMC Medical Genomics
BackgroundPreeclampsia (PE) is a pregnancy-related condition that affects both the infant and the mother. Although the role of various inflammatory molecules in PE has been demonstrated, the importance of pro-inflammatory molecules such as IL-17A, IL-23 is not well understood. In the present investigation, a potential association of common genetic ...
Kelly, Rachel S. Giorgio, Rachel T. Chawes, Bo L. Palacios, Natalia I. Gray, Kathryn J. Mirzakhani, Hooman Wu, Ann Blighe, Kevin Weiss, Scott T. Lasky-Su, Jessica
...
Published in
Metabolomics
IntroductionPreeclampsia represents a major public health burden worldwide, but predictive and diagnostic biomarkers are lacking. Metabolomics is emerging as a valuable approach to generating novel biomarkers whilst increasing the mechanistic understanding of this complex condition.ObjectivesTo summarize the published literature on the use of metab...
Pan, Xuefeng Wei, Benjie Wang, Hong Ma, Lingyu Du, Zhaoli Chen, Ying
Published in
BMC Pregnancy and Childbirth
BackgroundBoth genetic susceptibility and dysregulated lipid metabolism are important susceptibilities to preeclampsia. In the study, we devote to investigate the associations of FOXO3 and TLR7 genetic polymorphisms with preeclampsia in a Chinese population.MethodsThis case-control study involved 335 Han Chinese pregnant women, including 177 pregna...
Mulder, Eva Ghossein-Doha, Chahinda Appelman, Evine van Kuijk, Sander Smits, Luc van der Zanden, Rogier van Drongelen, Joris Spaanderman, Marc
Published in
BMC Pregnancy and Childbirth
BackgroundIn contrast to severe gestational hypertension, it is questioned whether antihypertensive medication for mild to moderate gestational hypertension prevents adverse maternal and offspring outcomes. Hypertensive drugs halve the risk of severe hypertension, but do not seem to prevent progression to preeclampsia or reduce the risk of complica...
Kazemi, Farideh Masoumi, Seyedeh Zahra Shayan, Arezoo Shahidi Yasaghi, Seyedeh Zahra
Published in
Agriculture & Food Security
BackgroundThe results of some studies have indicated the association between food insecurity and certain adverse pregnancy outcomes. The present study aimed to investigate the prevalence of food insecurity in pregnant women and its association with pregnancy outcomes and complications.MethodsThe present cross-sectional study was conducted on 772 mo...
Tang, Rui Zhang, Zhilei Han, Wenjun
Published in
Placenta
Many studies have shown that circular RNAs (circRNAs) are related to the occurrence of preeclampsia (PE). However, the role of circLRRK1 in the progression of PE is unclear. The identification and localization of circLRRK1 were verified by Actinomycin D (ActD) assay, Ribonuclease R (RNase R) digestion assay and subcellular localization assay. Moreo...
Godhamgaonkar, Aditi A Wadhwani, Nisha S Joshi, Sadhana R
Published in
Prostaglandins, leukotrienes, and essential fatty acids
Maternal nutrition during pregnancy plays a significant role in growth and development of the placenta and influencing pregnancy outcome. Suboptimal nutritional status during early gestational period compromises the normal course of pregnancy leading to adverse maternal and fetal outcomes. Omega-3 and omega-6 long chain polyunsaturated fatty acids ...
Marín, Reinaldo Chiarello, Delia I Abad, Cilia Rojas, Deliana Toledo, Fernando Sobrevia, Luis
Published in
Biochimica et biophysica acta. Molecular basis of disease
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by the onset of clinical signs and symptoms and delivery before (early-onset preeclampsia, eoPE), or after (late-onset preeclampsia, loPE), the 34 weeks of gestation. Preecl...
