Publication search
with Post-translational Modifications, Proteolysis & Proteomics as keyword
Le, Viet Q Iacob, Roxana E Tian, Yuan McConaughy, William Jackson, Justin Su, Yang Zhao, Bo Engen, John R Pirruccello-Straub, Michelle Springer, Timothy A
...
Published in
The EMBO journal
Growth differentiation factor 8 (GDF8)/myostatin is a latent TGF-β family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloid-cleaved GDF8 pro-complexes to understand structural mechanisms underlying latency and activation of GDF8. Negative stain electron microscopy...
Cotton, Thomas R Fischer, Gerhard Wang, Xuelu McCoy, Jason C Czepnik, Magdalena Thompson, Thomas B Hyvönen, Marko
Published in
The EMBO journal
Myostatin, a key regulator of muscle mass in vertebrates, is biosynthesised as a latent precursor in muscle and is activated by sequential proteolysis of the pro-domain. To investigate the molecular mechanism by which pro-myostatin remains latent, we have determined the structure of unprocessed pro-myostatin and analysed the properties of the prote...
