Dachy, A; Collard, L; Krzesinski, JM; Seghaye, MC; Ghuysen, MS; Mekahli, D; 62139; Jouret, F;
Polycystic kidney disease (PKD) is the most prevalent inherited kidney disease. The disease is usually asymptomatic until adulthood. End-stage renal disease occurs generally after the age of 55 years, with a large inter-individual variability. Renal cyst formation begins early in life, and animal models have shown that treatments able to prevent th...
Ghenu, Iuliana Maria Constantin, Rodica Ionescu, Dorin Dragos, Dorin
Published in
The American Journal of Case Reports
Patient: Male, 41-year-old Final Diagnosis: Autosomal dominant polycystic kidney disease Symptoms: Pain Medication: — Clinical Procedure: Computed tomography • ultrasonography Specialty: Gastroenterology and Hepatology • Medicine, General and Internal • Nephrology Objective: Congenital defects/diseases Background: Autosomal dominant polycystic kidn...
El-Damanawi, R Lee, Michael Harris, T Cowley, LB Bond, Simon Pavey, H Sandford, Richard Wilkinson, Ian Karet Frankl, FE Hiemstra, Thomas
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Kollabathula, Arpitha Vishwajeet, Vikarn Gupta, Kirti Mitra, Suvradeep Sharma, Vibhav Ray, Pallab Bhalla, Ashish
ABSTRACT We describe an autopsy case of a 45-year-old male diagnosed with autosomal dominant polycystic kidney disease who presented with complaints of altered sensorium. The autopsy revealed multiple tumor-like masses in the liver, which on histological examination depicted multiple large suppurative granulomas with the presence of variable acid-f...
Kollabathula, Arpitha Vishwajeet, Vikarn Gupta, Kirti Mitra, Suvradeep Sharma, Vibhav Ray, Pallab Bhalla, Ashish
Published in
Autopsy & Case Reports
We describe an autopsy case of a 45-year-old male diagnosed with autosomal dominant polycystic kidney disease who presented with complaints of altered sensorium. The autopsy revealed multiple tumor-like masses in the liver, which on histological examination depicted multiple large suppurative granulomas with the presence of variable acid-fast cocco...
Sanchis, Irina M Shukoor, Shehbaz Irazabal, Maria V Madsen, Charles D Chebib, Fouad T Hogan, Marie C El-Zoghby, Ziad Harris, Peter C Huston, John Brown, Robert D
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Published in
Clinical journal of the American Society of Nephrology : CJASN
Intracranial aneurysm rupture is the most devastating complication of autosomal dominant polycystic kidney disease. Whether selective or widespread intracranial aneurysm screening is indicated remains controversial. Records of 3010 patients with autosomal dominant polycystic kidney disease evaluated at the Mayo Clinic between 1989 and 2017 were rev...
Fowler, Kevin John
Published in
Clinical Journal of the American Society of Nephrology : CJASN
Bruschi, Maurizio Granata, Simona Santucci, Laura Candiano, Giovanni Fabris, Antonia Antonucci, Nadia Petretto, Andrea Bartolucci, Martina Del Zotto, Genny Antonini, Francesca
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Published in
Clinical journal of the American Society of Nephrology : CJASN
Microvesicles and exosomes are involved in the pathogenesis of autosomal dominant polycystic kidney disease. However, it is unclear whether they also contribute to medullary sponge kidney, a sporadic kidney malformation featuring cysts, nephrocalcinosis, and recurrent kidney stones. We addressed this knowledge gap by comparative proteomic analysis....
Bae, Kyongtae T Zhou, Wen Shen, Chengli Landsittel, Douglas P Wu, Zhiyuan Tao, Cheng Chapman, Arlene B Torres, Vicente E Yu, Alan S L Mrug, Michal
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Published in
Clinical journal of the American Society of Nephrology : CJASN
To evaluate the growth pattern of kidney cyst number and cyst volume in association with kidney size, demographics, and genotypes in autosomal dominant polycystic kidney disease. Kidney cyst number and cyst volume were measured from serial magnetic resonance images, giving a maximum follow-up of 14.23 years, from 241 patients with autosomal dominan...
Messchendorp, A Lianne van Londen, Marco Taylor, Jacob M de Borst, Martin H Navis, Gerjan Casteleijn, Niek F Gaillard, Carlo A J M Bakker, Stephan J L Gansevoort, Ron T
Published in
Clinical journal of the American Society of Nephrology : CJASN
It is assumed that in autosomal dominant polycystic kidney disease (ADPKD), kidney function remains in the normal range for several decades because of hyperfiltration of remnant nephrons. In this study, we investigate the extent to which patients with ADPKD hyperfilter. In this cross-sectional study, we measured GFR as urinary clearance using conti...