Resumen. El análisis de la noción de “espíritu de venganza” permite comparar la voluntad de poder nietzscheana con la libertad trascendental poliana con el fin de ampliar la metafísica con una antropología trascendental. La voluntad de poder supera el espíritu de venganza con el eterno retorno de lo mismo, pero está abocada al nihilismo. La liberta...
Pfänder and Polo both have carried out studies that are worth mentioning with regard to ethics. In this brief work we would like to rescue what is best in these two thinkers who, from rather disparate perspectives and methods, confront topics and resolve problems in ra- ther distinct ways to carry us to the safe port of personal being, each in his ...
This article establishes a dialogue around the concept of truth presented in Leonardo Polo’s thought and three contemporary thinkers. First, this article will perform an analysis of the french thinker Michel Foucault through his work "Discipline and punish: the birth of the prison". Second, it will describe the main points of confluence with the bo...
Published in Current biology : CB
Early embryogenesis is characterized by rapid and synchronous cleavage divisions, which are often controlled by wave-like patterns of Cdk1 activity. Two mechanisms have been proposed for mitotic waves: sweep and trigger waves.1,2 The two mechanisms give rise to different wave speeds, dependencies on physical and molecular parameters, and spatial pr...
Published in Journal of cell science
Polo kinase (PLK1 in mammals) is a master cell cycle regulator that is recruited to various subcellular structures, often by its polo-box domain (PBD), which binds to phosphorylated S-pS/pT motifs. Polo/PLK1 kinases have multiple functions at centrioles and centrosomes, and we have previously shown that in Drosophila phosphorylated Sas-4 initiates ...
Published in Journal of equine veterinary science
When compared with other equestrian sports, Polo players engage in a high number of player-pony interactions. To ensure optimal performance of the player-pony dyad, an understanding of the workloads performed by each pony and the physiological cost placed on the rider are required. This investigation examined the relationship and interaction betwee...
Taking into account the human constitutive and operational complexity, framed in the complexity of the physical, social and cultural reality, especially that of our historical time, we seek, following L. Polo’s thought, simplicity in human life, which is the result of the unity of life, fruit, in turn, of putting the real inferior human dimensions ...
Published in Journal of cell science
The DNA damage sensor Mre11-Rad50-Nbs1 complex and Polo kinase are recruited to DNA lesions during mitosis. However, their mechanism of recruitment is elusive. Here, using live-cell imaging combined with micro-irradiation of single chromosomes, we analyze the dynamics of Polo and Mre11 at DNA lesions during mitosis in Drosophila These two proteins ...
Published in The EMBO journal
Accurate chromosome segregation in mitosis requires sister kinetochores to bind to microtubules from opposite spindle poles. The stability of kinetochore-microtubule attachments is fine-tuned to prevent or correct erroneous attachments while preserving amphitelic interactions. Polo kinase has been implicated in both stabilizing and destabilizing ki...
The historical height of a thinker and a current of philosophy is measured by the cognitive acts that it mainly exercises and by the real acts it discovers. Neither are unrestricted, but we can always exercise more first and discover more of the latter. Polo has discovered the hierarchy of one and the other and has put hierarchical order among the ...
