James, T W Thomson, B J Naumann, D N Stevenson, D S
Published in
The Journal of laryngology and otology
Post-tonsillectomy bleeding is the most frequent complication of tonsillectomy. Inherited platelet function disorders have an estimated prevalence of 1 per cent. Any association between post-tonsillectomy bleeds and undiagnosed inherited platelet function disorders has not been investigated before. To assess the prevalence of inherited platelet fun...
Osojnik, Irena Kamenik, Mirt
Abstract Objective: To establish whether the use of diclofenac reduces the administration of opioids and how it affects bleeding and platelet function after the coronary artery bypass grafting (CABG) surgery with use of cardiopulmonary bypass (CPB). Methods: A total of 72 patients undergoing CABG surgery were included in this retrospective randomiz...
Osojnik, Irena Kamenik, Mirt
Published in
Brazilian Journal of Cardiovascular Surgery
Objective To establish whether the use of diclofenac reduces the administration of opioids and how it affects bleeding and platelet function after the coronary artery bypass grafting (CABG) surgery with use of cardiopulmonary bypass (CPB). Methods A total of 72 patients undergoing CABG surgery were included in this retrospective randomized study an...
van Geffen, Johanna P Brouns, Sanne LN Batista, Joana McKinney, Harriet Kempster, Carly Nagy, Magdolna Sivapalaratnam, Suthesh Baaten, Constance CFMJ Bourry, Nikki Frontini, Mattia
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Waller, Amie Lantos, Lajos Sammut, Audrienne Salgin, Burak McKinney, Harriet Foster, Holly R Kriek, Neline Gibbins, Jonathan M Stanworth, Simon J Garner, Stephen F
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Neonatal haemorrhaging is often co-observed with thrombocytopenia however no evidence of a causal relationship with low platelet count has been reported. Regardless, the administration of a platelet transfusion is often based upon this parameter. Accurate measurement of platelet function in small volumes of adult blood samples by flow cytometry is ...
Taylor, Kirk A Wilson, Darren GS Harper, Matthew Pugh, Nicholas
Anion channels perform a diverse range of functions and have been implicated in ATP release, volume regulation, and phosphatidylserine exposure. Platelets have been shown to express several anion channels but their function is incompletely understood. Due to a paucity of specific pharmacological blockers, we investigated the effect of extracellular...
Bozorgmanesh, Rana Sutton-Burges, Julie W Tablin, Fern
BackgroundEquine whole blood collection and storage methods have been evaluated to assess red blood cell viability; however, platelet (PLT) viability has not been comprehensively assessed.ObjectivesThe purpose of the study was to compare viability of PLTs collected in whole blood into 2 different anticoagulants.MethodsWhole blood from 6 healthy adu...
Berrou, Eliane Adam, Frédéric Lebret, Marilyne Planche, Virginie Fergelot, Patricia Issertial, Odile Coupry, Isabelle Bordet, Jean-Claude Nurden, Paquita Bonneau, Dominique
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Published in
Arteriosclerosis, thrombosis, and vascular biology
Dominant mutations of the X-linked filamin A (FLNA) gene are responsible for filaminopathies A, which are rare disorders including brain periventricular nodular heterotopia, congenital intestinal pseudo-obstruction, cardiac valves or skeleton malformations, and often macrothrombocytopenia. We studied a male patient with periventricular nodular hete...
Khalaf Adeli, Elham Mostafa Alavi, Seyed Alizadeh-Ghavidel, Alireza Bakhshandeh-Abkenar, Hooman Pourfathollah, Ali Akbar
Published in
Medical journal of the Islamic Republic of Iran
Background: Patients undergoing cardiac surgery are at increased risk of bleeding due to multifactorial coagulopathies. In the present study, we aimed at investigating the changes in platelet count and function during and after surgery as well as determining the association of the platelet dysfunction with bleeding and transfusion requirements in t...
Garner, SF Furnell, A Kahan, BC Jones, CI Attwood, A Harrison, P Kelly, AM Goodall, AH Cardigan, R Ouwehand, Willem
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