Oral, Alihan Sahin, Tolga Turker, Fatih Kocak, Erdem
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Platelets are considered to be essential in proinflammatory environments, including atherosclerosis. The degree of platelet activation has been demonstrated to be correlated with plateletcrit and platelet distribution width. The main purpose of this study was to assess the relationship between plateletcrit (PCT), platelet distribution, a...
Wang, Lin-Hui Chen, Chi Wang, Qing Song, Jun Cao, Jun Guo, Peng-Xiang
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background In China, evidence regarding to the association between platelet to lymphocyte ratio (PLR) and glucocorticoid (GC) resistance in participants with primary newly identified immune thrombocytopenia (ITP) is limited. We aimed to investigate whether PLR is independently linked with GC-resistant ITP. Material/Methods We non-selectively and co...
Ivanov, Ivelin I Apta, Bonita HR Bonna, Arkadiusz Harper, Matthew
Tissue factor (TF) plays a central role in haemostasis and thrombosis. Following vascular damage, vessel wall TF initiates the extrinsic coagulation cascade. TF can also be exposed by monocytes. Inflammatory or infectious stimuli trigger synthesis of new TF protein by monocytes over the course of hours. It has also been suggested that monocytes can...
Bikulčienė, Inga Golubevaitė, Orinta Žėkas, Vytautas Radzevičius, Mantas Karčiauskaitė, Dovilė Matuzevičienė, Rėda Hendrixson, Vaiva Mažeikienė, Asta Burokienė, Neringa Kaminskas, Arvydas
...
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Platelet membranes are extremely susceptible to peroxidation, forming a variety of lipid peroxides, including malondialdehyde (MDA), which has been implicated in the etiology of cardiovascular diseases. Moreover, platelet-leukocyte aggregates (PLAs) are known to contribute to advanced endothelial injury and atherogenesis. Material/Method...
Li, Ronald HL Nguyen, Nghi Tablin, Fern
BackgroundFunctional Toll-like receptor 4 (TLR4) has been characterized in human and murine platelets indicating that platelets play a role in inflammation and hemostasis during sepsis. It is unclear whether canine platelets could express functional TLR4 by responding to its ligand, lipopolysaccharide (LPS). We sought to determine if dogs express f...
van Geffen, Johanna P Brouns, Sanne LN Batista, Joana McKinney, Harriet Kempster, Carly Nagy, Magdolna Sivapalaratnam, Suthesh Baaten, Constance CFMJ Bourry, Nikki Frontini, Mattia
...
Schroer, Adam B Horowitz, Alana M Villeda, Saul A
Exercise boosts neural stem and progenitor cell proliferation and differentiation in the dentate gyrus region of the hippocampus. In this issue of Stem Cell Reports, Leiter et al. (2019) identify acute exercise-induced platelet activation and platelet factor-4 as novel systemic mediators of adult hippocampal neurogenesis.
Waller, Amie Lantos, Lajos Sammut, Audrienne Salgin, Burak McKinney, Harriet Foster, Holly R Kriek, Neline Gibbins, Jonathan M Stanworth, Simon J Garner, Stephen F
...
Neonatal haemorrhaging is often co-observed with thrombocytopenia however no evidence of a causal relationship with low platelet count has been reported. Regardless, the administration of a platelet transfusion is often based upon this parameter. Accurate measurement of platelet function in small volumes of adult blood samples by flow cytometry is ...
Barrachina, María N Sueiro, Aurelio M Izquierdo, Irene Hermida-Nogueira, Lidia Guitián, Esteban Casanueva, Felipe F Farndale, Richard Moroi, Masaaki Jung, Stephanie Pardo, María
...
Abstract: Background and aims: Platelets play a fundamental role in the increased atherothrombotic risk related to central obesity since they show hyperactivation and lower sensitivity to antiplatelet therapy in obese patients. The main goal of this study was to identify platelet biomarkers related to the risk of suffering atherothrombosis in obese...
Denis, Hélèna L Lamontagne-Proulx, Jérôme St-Amour, Isabelle Mason, Sarah Rowley, Jesse W Cloutier, Nathalie Tremblay, Marie-Ève Vincent, Antony T Gould, Peter V Chouinard, Sylvain
...
Huntington's disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene (Htt) which results in the production of an abnormal protein, mutant huntingtin (mHtt). This protein is ubiquitously expressed and know...
