Witte, Alexander Rohlfing, Anne-Katrin Dannenmann, Benjamin Dicenta, Valerie Nasri, Masoud Kolb, Kyra Sudmann, Jessica Castor, Tatsiana Rath, Dominik Borst, Oliver
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Published in
Cardiovascular research
Beyond classical roles in thrombosis and haemostasis, it becomes increasingly clear that platelets contribute as key players to inflammatory processes. The involvement of platelets in these processes is often mediated through a variety of platelet-derived chemokines which are released upon activation and act as paracrine and autocrine factors. In t...
Peng, Wei Li, Chuan Zhang, Xiaoyun Wen, Tianfu Chen, Zheyu
Published in
World journal of surgical oncology
Thrombocytopenia was reported both detrimental and advantageous to hepatocellular carcinoma (HCC). However, there is little evidence showing clearly the clinical value of preoperative thrombocytopenia on the surgical outcome of patients with small HCC. This retrospective study aimed at elucidating the correlation between preoperative thrombocytopen...
Honda, Takeshi Kanaoka, Yuji Furukawa, Hiroshi Tamura, Taishi Kuwada, Noriaki Yamasawa, Takahiko Watanabe, Yoshiko Yunoki, Yasuhiro Tabuchi, Atsushi Tanemoto, Kazuo
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Published in
Journal of Cardiothoracic Surgery
ObjectivesThe aim of this study is to evaluate the possibility of the autologous platelet-rich plasma (PRP) collection from the cardiopulmonary bypass (CPB) circuit and to evaluate its effect on the aggregative function.MethodsFor seventy-two patients undergoing cardiac surgery with CPB, an autologous PRP was prepared using the Haemonetics Componen...
Shimizu, Yuji Arima, Kazuhiko Noguchi, Yuko Kawashiri, Shin-Ya Yamanashi, Hirotomo Tamai, Mami Nagata, Yasuhiro Maeda, Takahiro
Published in
Environmental Health and Preventive Medicine
BackgroundHuman T-cell leukemia virus type 1 (HTLV-1) activates inflammatory cascades by activating the NF-κB pathway. The minor allele of single nucleotide polymorphism (SNP) in breast cancer suppressor BRCA1-associated protein (BRAP), which has a common etiology with HTLV-1 infection, has been reported to be positively associated with carotid ath...
Chen, Yen-Chun Ko, Ping-Hung Lee, Chi-Che Tseng, Chih-Wei Tseng, Kuo-Chih
Published in
BMC Gastroenterology
BackgroundThrombocytopenia can rapidly improve in chronic hepatitis C (CHC) patients receiving direct-acting antiviral agents (DAA). The role of baseline (BL) thrombopoietin (TPO) in this phenomenon is unclear.MethodsFrom June 2016 to February 2019, a total of 104 CHC patients receiving DAA, with a sustained virologic response and BL thrombocytopen...
Pascoal, Martim de Almeida Nóbrega Corre... dos Santos, Nuno Bernardo Malta Completo, António Manuel Godinho Fernandes, Gustavo Vicentis de Oliveira
Published in
International Journal of Implant Dentistry
BackgroundSince the leucocyte-platelet rich fibrin (L-PRF) was published in 2001, many studies have been developed, analyzing its properties, and also verifying new possibilities to improve it. Thereby, it emerges the advanced-platelet rich fibrin (A-PRF) with a protocol that optimizes the properties obtained by the L-PRF. Nonetheless, there is a g...
Wu, Limeng Guo, Ninghong Xu, Zhenyan Wang, Wei Xiong, Qinmei Hu, Jinzhu Wan, Rong Hong, Kui
Published in
BMC Pulmonary Medicine
BackgroundRecent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether the pathophysiological state of the lung affect the platelets is little known. We aim to investigate the incidence of thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated with pulmonary thrombocytop...
Majidpoor, Jamal Mortezaee, Keywan
Published in
Medical Oncology
Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter being less common but more efficient. Initiation of metastasis relies on the tumor cell cross-talking with stromal cells and taking an epithelial-mesenchymal tra...
Jafari Azad, Banafsheh Daneshzad, Elnaz Meysamie, Ali Pasha Koohdani, Fariba
Published in
Critical reviews in food science and nutrition
The findings of trials investigating the effect of cocoa products consumption on vascular stiffness and platelet are controversial. The aim of this study is to summarize the findings on the acute and chronic effects of different forms of cocoa on the risk factors of cardiovascular disease. We searched SCOPUS, Pub Med and Web of Science from incepti...
Balkenhol, Johannes Kaltdorf, Kristin V. Mammadova-Bach, Elmina Braun, Attila Nieswandt, Bernhard Dittrich, Marcus Dandekar, Thomas
Published in
BMC Genomics
BackgroundUnderstanding the molecular mechanisms of platelet activation and aggregation is of high interest for basic and clinical hemostasis and thrombosis research. The central platelet protein interaction network is involved in major responses to exogenous factors. This is defined by systemsbiological pathway analysis as the central regulating s...