He, Keli Xie, Xiaorui Duan, Xiangjie Zhou, Quan Wu, Jianhua
Published in
Cerebrovascular diseases (Basel, Switzerland)
The red blood cell distribution width-to-platelet ratio (RPR), a novel inflammatory index, has already been proven as a prognostic factor in some other diseases, but its prognostic effect on critically ill patients with acute ischemic stroke (AIS) has been rarely investigated. This study aimed to investigate the association between RPR and in-hospi...
Solari, Fiorella A; Krahn, Daniel; Swieringa, Frauke; Verhelst, Steven; 100754; Rassaf, Tienush; Tasdogan, Alpaslan; Zahedi, Rene P; Lorenz, Kristina; Renne, Thomas; Heemskerk, Johan WM;
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Platelets are small anucleate cell fragments (2-4 μm in diameter) in the blood, which play an essential role in thrombosis and hemostasis. Genetic or acquired platelet dysfunctions are linked to bleeding, increased risk of thromboembolic events and cardiovascular diseases. Advanced proteomic approaches may pave the way to a better understanding of ...
Kimmerlin, Quentin Strassel, Catherine Eckly, Anita Lanza, François
Published in
Seminars in cell & developmental biology
Blood platelets are small non-nucleated cellular fragments that prevent and stop hemorrhages. They are produced in the bone marrow by megakaryocytes through megakaryopoiesis. This intricate process involves profound microtubule rearrangements culminating in the formation of a unique circular sub-membranous microtubule array, the marginal band, whic...
David, Victor Wermelinger, Luciana Serrão Frattani, Flávia Serra Lima, Antonio Gilclêr Ferreira Santos, Yasmyn Fernandes Silva Mourão, Paulo Antônio de Souza Almeida, Fabio Ceneviva Lacerda Kurtenbach, Eleonora Zingali, Russolina Benedeta
Published in
Archives of biochemistry and biophysics
Integrins are a family of heterodimeric transmembrane receptors which link the extracellular matrix to the cell cytoskeleton. These receptors play a role in many cellular processes: adhesion, proliferation, migration, apoptosis, and platelet aggregation, thus modulating a wide range of scenarios in health and disease. Therefore, integrins have been...
Li, Xiaohua Zhang, Guoxing Cao, Xia
Published in
Cardiovascular drugs and therapy
In addition to the key role in hemostasis and thrombosis, platelets have also been wildly acknowledged as immune regulatory cells and involving in the pathogenesis of inflammation-related diseases. Since purine receptor P2Y12 plays a crucial role in platelet activation, P2Y12 antagonists such as clopidogrel, prasugrel, and ticagrelor have been wide...
Hao, Lixia Ren, Juan Zhu, Yanlin Ma, Yanping Pan, Jie Yang, Linhua
Published in
International Archives of Allergy and Immunology
Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by excessive inflammatory responses. This study explored the association between laboratory characteristics and outcomes in adult patients with HLH. Methods: The adult patients diagnosed with HLH at the Second Hospital of Shanxi Medical University fr...
Maaninka, Katariina Neuvonen, Maarit Kerkelä, Erja Hyvärinen, Kati Palviainen, Mari Kamali-Moghaddam, Masood Federico, Antonio Greco, Dario Laitinen, Saara Öörni, Katariina
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Platelet extracellular vesicles (PEVs) generated upon platelet activation may play a role in inflammatory pathologies such as atherosclerosis. Oxidized low-density lipoprotein (oxLDL), a well-known contributor to atherogenesis, activates platelets and presensitizes them for activation by other agonists. We studied the effect of oxLDL on the secreti...
Liu, Yufei Hu, Haofei Li, Zongyang Yang, Jihu Zhang, Xiejun Chen, Lei Chen, Fanfan Li, Weiping Ji, Nan Huang, Guodong
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Published in
BMC neurology
Evidence regarding the relationship between preoperative platelet and 30-day postoperative mortality of intracranial tumor patients undergoing craniotomy is still limited. Therefore, the present research was conducted to explore the link of the platelet and 30-day postoperative mortality. Electronic medical records of 18,642 adult patients undergoi...
Pizzato, Sabrina Beal Terraciano, Paula Barros Zanon, Pamela Kuhl, Cristiana Palma Alves Garcez, Tuane Nerissa Passos, Eduardo Pandolfi Tirloni, Lucas Berger, Markus
Published in
Molecular and cellular endocrinology
In this study, we investigated how platelets and aorta contribute to the creation and maintenance of a prothrombotic state in an experimental model of postmenopausal hypertension in ovariectomized rats. Bilateral ovariectomy was performed in both 14-week-old female spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats. The anima...
Li, Quan Zhang, Tiening Wang, Lingfeng Li, Fang Chen, Qiang Cao, Shengjun Ba, Te
Published in
Injury
The aim of this study was to retrospectively analyze Thrombelastography (TEG) data of severe burn patients to provide a clinical basis for timely diagnosis and treatment of coagulation dysfunction. The present study comprised burn patients with full thickness TBSA ≥ 60%. The patients included in the study were admitted to the Third Affiliated Hospi...
