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Biologically effective dose (BED) of stereotactic body radiation therapy (SBRT) was an important factor of therapeutic e...

Published in BMC Cancer

BackgroundTo explore the association between biologically effective dose (BED) and survival rates in Child-Pugh A classification (CP-A) small hepatocellular carcinoma (HCC) patients treated with stereotactic body radiation therapy (SBRT).MethodsThis retrospective study included 108 small HCC patients who were treated with SBRT between 2011 and 2014...

Tubulin in Platelets: When the Shape Matters

1-tubulin modifications may participate in pathological and physiological processes, such as development.

Rapid decline of noninvasive fibrosis index values in patients with hepatitis C receiving treatment with direct-acting a...

Published in BMC Gastroenterology

BackgroundStudies on temporal changes in noninvasive fibrosis indices and liver stiffness measurement (LSM) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral agents (DAAs) are limited.MethodsWe retrospectively enrolled consecutive patients with CHC who had received DAAs.ResultsIn total, we recruited 395 consecutive pat...

Platelet adhesion on commercially pure titanium plates in vitro I: effects of plasma components and involvement of the v...

Published in International Journal of Implant Dentistry

BackgroundPlatelet-rich plasma (PRP) is widely used in regenerative dentistry. Furthermore, it is often applied in the pretreatment of titanium implants to improve their surface bioaffinity and initial stability. However, effects of PRP application on implant surface at cellular and molecular levels remain poorly understood. Therefore, we examined ...

Establishment and maintenance of blood–lymph separation

Published in Cellular and Molecular Life Sciences

Hippocratic Corpus, a collection of Greek medical literature, described the functional anatomy of the lymphatic system in the fifth century B.C. Subsequent studies in cadavers and surgical patients firmly established that lymphatic vessels drain extravasated interstitial fluid, also known as lymph, into the venous system at the bilateral lymphoveno...

C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation

Published in Cell Communication and Signaling

BackgroundMegakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activator of Rap1 GTPases, is involved in platelet activation and regulates several differentiation processes.MethodsWe evaluated C3G func...

Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation

Published in Cell Communication and Signaling

BackgroundPreviously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood.MethodsUsing single receptor-deficient platelets from TAM knockout mice in the C57BL/6 J strain, we performed a knockout study using single T...