Hagan, Kobina Mszar, Reed Cainzos-Achirica, Miguel Blaha, Michael J Shapiro, Michael D Arias, Lara Saxena, Anshul Cury, Ricardo Budoff, Matthew J Feldman, Theodore
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Published in
Atherosclerosis
We aimed to investigate the interplay between low-density lipoprotein-cholesterol (LDL-C) and coronary plaque in asymptomatic cohorts undergoing coronary tomography angiography (CCTA) assessment in the United States. A cross-sectional analysis of baseline data from 1808 statin-naïve participants in the Miami Heart Study was conducted. We assessed C...
Isodono, Koji Matsumoto, Hidenari Li, Debiao Slomka, Piotr Dey, Damini Cadet, Sebastien Irie, Daisuke Higuchi, Satoshi Tanisawa, Hiroki Nakazawa, Motoki
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Purpose To clarify the predominant causative plaque constituent for periprocedural myocardial injury (PMI) following percutaneous coronary intervention: (a) erythrocyte-derived materials, indicated by a high plaque-to-myocardium signal intensity ratio (PMR) at coronary atherosclerosis T1-weighted characterization (CATCH) MRI, or (b) lipids, represe...
Sandhu, Yasmin K Bath, Harman S Shergill, Jasmine Liang, Christopher Syed, Amina U Ngo, Allyson Karim, Fariha Serrano, Geidy E Beach, Thomas G Mukherjee, Jogeshwar
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The diagnostic value of imaging Aβ plaques in Alzheimer's disease (AD) has accelerated the development of fluorine-18 labeled radiotracers with a longer half-life for easier translation to clinical use. We have developed [18F]flotaza, which shows high binding to Aβ plaques in postmortem human AD brain slices with low white matter binding. We report...
Butler, Claire A Arvilla, Adrian Mendoza Milinkeviciute, Giedre Da Cunha, Celia Kawauchi, Shimako Rezaie, Narges Liang, Heidi Y Javonillo, Dominic Thach, Annie Wang, Shuling
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BackgroundVariants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD).MethodsCRISPR-Cas9 was used to generate an Abca7V1613M variant in mice, modeling the homologous human ABCA7V1599M variant, and extensive characterization was performed.ResultsAbca7V1...
Yoshinaga, Miyu Yuasa, Eika Matsuoka, Tetsuro Kihara, Shinji Yamamoto, Hiroyasu
Published in
Journal of atherosclerosis and thrombosis
Identifying patients with vulnerable plaque who have poor prognosis among those with coronary artery disease (CAD) is crucial to deciding future therapeutic interventions. We previously reported that male CAD patients with low anti-apolipoprotein B-100 autoantibody (anti-apoB-100 Ab) levels were at an increased risk of developing unstable plaque le...
Aldana-Bitar, Jairo Bhatt, Deepak L Budoff, Matthew J
Published in
Trends in cardiovascular medicine
Atherosclerotic plaque assessment has become a crucial element in the examination of cardiovascular diseases. Plaque may exhibit progression and could become unstable if not treated, making plaque regression and stabilization among the most important goals of any cardiovascular intervention in cardiovascular medicine. In this review, we explore the...
Vu, Ashley A
The purpose of this study is to develop a test method to non-invasively measure the development of subclinical atherosclerosis through acoustic sound wave analysis. This test method involves the manufacturing and use of silicone arteries with varying relative roughness values in their inner diameters to mimic arterial plaque buildup, a flow model, ...
Nurmohamed, Nick van Rosendael, Alexander Danad, Ibrahim Ngo-Metzger, Quyen Taub, Pam Ray, Kausik Figtree, Gemma Bonaca, Marc Hsia, Judith Rodriguez, Fatima
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Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individuals complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary com...
Verstraelen, Sandra; Roymans, Dirk; Jacobs, An; Hollanders, Karen; Remy, Sylvie; Jochmans, Dirk; 15412; Klein, Jelle; Grauwet, Tini;
In 2018, SGS Belgium NV developed RSV-NICA (Respiratory Syncytial Virus-Nasobronchial Infective Challenge Agent), an RSV type A challenge agent for use in RSV Controlled Human Infection Model (CHIM) studies.It is widely recognized that the stability of RSV can be influenced by a variety of environmental parameters, such as temperature and pH. Conse...
Henningfield, Caden Soni, Neelakshi Lee, Ryan Sharma, Rishi Cleland, Jeffrey Green, Kim
BACKGROUND: In Alzheimers disease (AD), microglia surround extracellular plaques and mount a sustained inflammatory response, contributing to the pathogenesis of the disease. Identifying approaches to specifically target plaque-associated microglia (PAMs) without interfering in the homeostatic functions of non-plaque associated microglia would affo...
