Synthetic meat, racism at the poles, and the long road to the opioid crisis: Books in Brief
Published in Nature
Barbara Kiser reviews five of the week’s best science picks. Books in Brief reel 5th September
CRISPR for Neuromuscular Disorders: Gene Editing and Beyond.
This is a review describing advances in CRISPR/Cas-mediated therapies for neuromuscular disorders (NMDs). We explore both CRISPR-mediated editing and dead Cas approaches as potential therapeutic strategies for multiple NMDs. Last, therapeutic considerations, including delivery and off-target effects, are also discussed.
An in vitro model to explore subchondral perfusion and intraosseous pressure
Published in Journal of Experimental Orthopaedics
BackgroundLittle is known about subchondral perfusion physiology. We developed a 3Rs (Replace, Reduce, Refine) compliant in vitro calf foot model to explore perfusion and intraosseous pressure (IOP).MethodsCalf feet were catheterised and perfused with serum. IOP was measured at three sites, the metacarpal diaphysis (MCD), metacarpal subchondral epi...
Profile of Educational Technology Use by Medical Students and Evaluation of a New Mobile Application Designed for the St...
Published in Journal of Medical Systems
Nowadays, smartphones represent an invaluable tool to access educational material; however, the available information is not always accurate or evidence-based. Therefore, we aimed to evaluate the use of technology by medical students and assess the effect of a newly developed mobile app for the study of human physiology. We used a standardised ques...
Exaggerated cardiovascular responses to muscle contraction and tendon stretch in UCD type-2 diabetes mellitus rats.
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Patients with type-2 diabetes mellitus (T2DM) have exaggerated sympathetic activity and blood pressure responses to exercise. However, the underlying mechanisms for these responses, as well as how these responses change throughout disease progression, are not completely understood. For this study, we examined the effect of the progression of T2DM o...
How a revolutionary technique got people with spinal-cord injuries back on their feet
Published in Nature
Electrical stimulation has promised huge gains for people with paralysis. Now comes the hard part — getting beyond those first steps. Credit: Luke Sharrett for Nature
A saga of extinction, Tesla in his time, and explorations under the surface of skin: Books in brief
Published in Nature
Barbara Kiser reviews five of the week’s best science picks. Five book covers
Ileal interposition surgery targets the hepatic TGF-β pathway, influencing gluconeogenesis and mitochondrial bioenergeti...
Ileal interposition (IT) is a surgical procedure that increases the delivery of incompletely digested nutrients and biliary and pancreatic secretions to the distal intestinal mucosa. Here, we investigated the metabolic impact of this intervention in 2-mo-old prediabetic University of California, Davis type 2 diabetes mellitus rats by assessing live...
Impacts of Potassium Ferrate(VI) on the Growth, Protein, and Enzyme of the Microcystis aeruginosa
Published in Water, Air, & Soil Pollution
As potassium ferrate(VI) is an important kind of water treatment agent which has a high efficiency in algal removal, its effects on the cell substance are rarely discussed. The changing of the protein and enzyme was analyzed here to deeply understand the oxidation of Fe on the protein in the algae. The result of the research showed the inactivation...
Hornets possess long-lasting olfactory memories.
The ability of animals to learn and remember is an important adaptation for coping with environmental changes. The fitness benefits provided by these cognitive skills, in conjunction with social behaviours, contribute to the success of social insects. How these abilities are shared among the different castes and the long-term persistence of memory ...
