Soy, Rodah Babu, Balaji Mack, John Nyokong, Tebello
Published in
Photodiagnosis and photodynamic therapy
A series of tetraarylporphyrin, -chlorin and N-confused porphyrin dyes with 4‑methoxy‑meso-aryl rings (1-Por, 1-Chl and 1-NCP) and their Sn(IV) complexes (1-SnPor, 1-SnChl and 1-SnNCP) have been synthesized and characterized. The heavy atom effect of the Sn(IV) ion results in relatively high singlet oxygen quantum yield values of 0.67, 0.71 and 0.8...
Hlabangwane, Kamogelo Matshitse, Refilwe Managa, Muthumuni Nyokong, Tebello
Published in
Photodiagnosis and photodynamic therapy
The World Health Organization has reported that antimicrobial resistance is one of the top 10 health threats that humanity faces today. Due to this, alternative therapies to the common antimicrobials are being explored and among these is photodynamic antimicrobial chemotherapy, where a combination of light, a photosensitizer and reactive oxygen spe...
Ledwaba, Mahlatse Mokgaetjie Magaela, Ngwanabjala Bridged Ndlovu, Knowledge Siyabonga Mack, John Nyokong, Tebello Managa, Muthumuni
Published in
Photodiagnosis and photodynamic therapy
Pathogenic microorganisms may continue causing infection through the transfer of antibiotic resistance genes. As a result, the efficacy of pharmaceuticals in microbial inactivation is deteriorating. The present study was conducted to investigate the antimicrobial activity of neutral and quaternized free base and Zn 5,10,15,20-tetra(pyridin-3-yl) po...
Sindelo, Azole Nyokong, Tebello
Published in
Heliyon
ClIn(III) octacarboxy phthalocyanine (ClInOCPc) when alone or conjugated to magnetic nanoparticles (MNP-ClInOCPc) was employed for both photodynamic antimicrobial chemotherapy of an unknown water sample and Staphylococcus aureus, and for photo-degradation of methyl red (MR). The singlet oxygen quantum yields (Φ Δ) in water using ClInOCPc and MNP-Cl...
Mafukidze, Donovan M Sindelo, Azole Nyokong, Tebello
Published in
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Silver triangular nanoprisms were synthesized and conjugated to zinc (ZnPc) and indium (InPc) phthalocyanines prior to embedding in asymmetric membranes. Conjugation of nanoparticles increased triplet state and singlet oxygen quantum yields of the phthalocyanines as well as enhancing photodynamic antimicrobial chemotherapy (PACT) activity against b...
de Carvalho Leonel, Leonardo Carvalho, Moisés Lopes da Silva, Bruna Marques Zamuner, Stella Alberto-Silva, Carlos Silva Costa, Maricilia
Published in
Photodiagnosis and photodynamic therapy
Candida albicans is an opportunistic fungus, an etiological agent of human infections, presenting high rates of morbidity and mortality. The resistance of C. albicans to conventional therapies has been reported due to the extensive use of conventional antifungals. Photodynamic antimicrobial chemotherapy (PACT) is a technique that combines a visible...
Carvalho, Moisés Lopes Pinto, Ana Paula Raniero, Leandro José Costa, Maricilia Silva
Published in
Lasers in Medical Science
Candida albicans is an opportunistic fungal producing both superficial and systemic infections in immunocompromised patients. Furthermore, it has been described an increase in the frequency of infections which have become refractory to standard antifungal therapy. Photodynamic antimicrobial chemotherapy (PACT) is a potential antimicrobial therapy t...
Gao, Yiru Mai, Bingjie Wang, Ao Li, Min Wang, Xiaobing Zhang, Kun Liu, Quanhong Wei, Shaohua Wang, Pan
Published in
Photodiagnosis and photodynamic therapy
Bacterial infection is a common clinical problem. Community-associated Staphylococcus aureus (S. aureus) infections can cause extensive tissue damage and necrosis. Photodynamic antimicrobial chemotherapy (PACT) has recently attracted attention as a feasible bacterial therapy. Octa-cationic zinc phthalocyanines are newly identified photosensitizers ...
da Silva, Bruna Graziele Marques Carvalho, Moisés Lopes Rosseti, Isabela Bueno Zamuner, Stella Costa, Maricilia Silva
Published in
Lasers in Medical Science
Among non-albicans Candida species, the opportunistic pathogen Candida krusei emerges because of the high mortality related to infections produced by this yeast. The Candida krusei is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infections produced by C. krusei, its occurrence is incr...
Le Guern, Florent
L’émergence de nouvelles souches bactériennes résistantes a signé la fin de l’« âge d’or » des antibiotiques. L’organisation mondiale de la santé a reconnu l’imminence des problèmes associés à ces nouvelles bactéries, qui engendrent de nouveau une mortalité en augmentation. Afin de palier à ce problème, de nouvelles alternatives aux antibiotiques s...
