Gholivand, Khodayar Faraghi, Mohammad Pooyan, Mahsa Babaee, Leila Sarmadi Malekshah, Rahime Eshaghi Pirastehfar, Foroogh Vahabirad, Mohammad
Published in
Current medicinal chemistry
Graphene oxide (GO)-based systems are among the drug delivery systems and have drawn a lot of interest in the field of medicine. In this work, two novel phosphoramides with the formulas of (NHCHCH2C(CH3)2NHC(CH3)2CH2P(S)(OEt)2 (L1) and (NHCHCH2C(CH3)2 NHC (CH3)2CH2P (O) (NHC6H5) (OC5H6) (L2) were synthesized and characterized by spectroscopic metho...
Kaur, Hardeep; Persoons, Leentje; 47655; Andrei, Graciela; 3409; Singh, Kamaljit;
A novel class of quinoline-dihydropyrimidin-2(1H)-one (DHPM) hybrids was synthesized and in vitro antiplasmodial activity was evaluated against chloroquine sensitive (D10) and chloroquine resistant (Dd2) strains of Plasmodium falciparum, the human malaria parasite. The antiplasmodial activity was compared to previously reported DHPM based molecular...
Gholivand, Khodayar Faraghi, Mohammad Fallah, Nasrin Satari, Mohammad Pooyan, Mahsa
Published in
Bioorganic chemistry
In this study, two new phosphoramides containing imidazolidine; diphenyl (2-imidazolidinone-1-yl)phosphonate (DIOP) and diphenyl (2-Imidazolidinethione -1-yl)phosphonate (DITP) as cytotoxic agents, were synthesized and characterized by using IR, 1H NMR, 13C NMR, 31P NMR, Mass spectroscopy and elemental analysis. The target products were obtained in...
Gholivand, Khodayar Roshanian, Zahra Rahimzadeh Dashtaki, Maryam Hosseini, Zahra Ebrahimi Valmoozi, Ali Asghar Sharifi, Mahboobeh Mohammadpanah, Fahimeh Rajabi, Maryam Ghadamyari, Mohammad Farshadian, Sedigheh
...
Published in
Molecular diversity
Synthesizing new chemical compounds and studying their biological applications have been important issues in scientific research. In this investigation, we synthesized and characterized ten new N-acetyl phosphoramidate compounds and explored the crystal structure of three others. Furthermore, not only were some kinetic inhibition parameters measure...
Gerard, Yvain Voissière, Aurélien Peyrode, Caroline Galmier, Marie-Josephe Maubert, Elise Ghedira, Donia Tarrit, Sebastien Gaumet, Vincent Canitrot, Damien Miot-Noirault, Elisabeth
...
Published in
Bioorganic chemistry
The tumor microenvironment in chondrosarcoma (CHS), a chemo- and radio-resistant cancer provides unique hallmarks for developing a chondrosarcoma targeted drug-delivery system. Tumor targeting could be achieved using a quaternary ammonium function (QA) as a ligand for aggrecan, the main high negative charged proteoglycan of the extracellular matrix...
Shariatinia, Zahra Javeri, Nasrin Shekarriz, Shahla
Published in
Carbohydrate polymers
Flame retardant cotton fibers were successfully produced using five new nanosized phosphoramide compounds synthesized by ultrasonic method. The (1)H NMR spectra of compounds 1-3 illustrate (3)J(H,H)cis and (3)J(H,H)trans corresponding to the splittings of cis and trans protons present in the CHCH2 bond. Comparing the char lengths of cotton fibers t...
Gholivand, Khodayar Mahzouni, Hamid Reza Esrafili, Mehdi D.
Published in
Theoretical Chemistry Accounts
Novel comparison of the structural, electronic and energy aspects of lanthanide complexes of model phosphoramides (PAs) with those of phosphine oxides (POs), phosphate esters (PEs) and phosphoryl trihalides (PHs) has been carried out by ab initio and DFT calculations. Atoms in Molecules (AIM) and Natural Bonding Orbital (NBO) analyses were performe...
FRAIX, Aurore JAFFRES, Paul-Alain
FR
FRAIX, Aurore JAFFRES, Paul-Alain
L'introduction d acides nucléiques dans des cellules cibles présente un intérêt pour le développement de nouvelles stratégies thérapeutiques visant différents types d'affections (e.g. maladies monogéniques, cancers). La famille des lipophosphoramides développée au laboratoire a montré des efficacités de transfection intéressantes tant in vitro qu i...
Shchepin, V. V. Silaichev, P. S. Stepanyan, Yu. G. Russkikh, N. Yu. Vakhrin, M. I. Ezhikova, M. A. Kodess, M. I.
Published in
Russian Journal of Organic Chemistry
Organozinc compounds prepared from bromomalonic acid esters and zinc react with 3-aryl-2-cyanopropenoic acid primary amides giving a single diastereomer of the corresponding 1-R′-4-aryl-2,6-dioxo-5-cyanopiperidine-3-carboxylic acid esters, or 3-R′-6-aryl-2,4-dioxo-5-cyano-3-azabicyclo[3.1.0]hexene-1-carboxylic acid esters.
