Mei, Dan Tan, W S Daniel Liao, Wupeng Heng, C K Matthew Wong, W S Fred
Published in
Pharmacological research
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of COPD. This study aimed to investigate potential protective effects of angiotensin II type-2 receptor (AT2R) activation in cigarette smoke (CS)-induced COPD models. Compou...
Zhang, Jinwei Cordshagen, Antje Medina, Igor Nothwang, Hans Gerd Wisniewski, Jacek Winklhofer, Michael Hartmann, Anna-Maria
The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in post-transcriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (broad kinase inhibitor) and N-ethylmalemide (NEM) that modulate kinase and phosphatase activit...
Lemanowicz, Joanna Brzezińska, Małgorzata Siwik-Ziomek, Anetta Koper, Jan
Published in
The Science of the total environment
This paper presents phosphorus content, the activity of enzymes, and relationships between chemical properties in former sulphur mine soil ecosystems. Soil sampled 16 years after the completion of open-pit mining works at Machów, and 7 years after sulphur mining by the "melting" method was abandoned in the Jeziórko mine. In these soil samples were ...
Della Mónica, Ivana F Godeas, Alicia M Scervino, José M
Published in
Microbial ecology
Phosphorus (P) is an essential nutrient with low bioavailability in soils for plant growth. The use of P solubilization fungi (PSF) has arisen as an eco-friendly strategy to increase this nutrient's bioavailability. The effect of PSF inoculation and its combination with P-transporting organisms (arbuscular mycorrhizal fungi, AMF) on plant growth ha...
Bellio, Marie Caux, Manuella Vauclard, Alicia Chicanne, Gaëtan Gratacap, Marie-Pierre Terrisse, Anne-Dominique Severin, Sonia Payrastre, Bernard
Published in
Advances in biological regulation
Blood platelets, produced by the fragmentation of megakaryocytes, play a key role in hemostasis and thrombosis. Being implicated in atherothrombosis and other thromboembolic disorders, they represent a major therapeutic target for antithrombotic drug development. Several recent studies have highlighted an important role for the lipid phosphatidylin...
Zhao, Ying Yu, Huan He, Lei Li, Ni Huang, Guo-Hua
Published in
Virus genes
The open reading frame 117 (3h-117) of Heliothis virescens ascovirus 3h (HvAV-3h), which is a conserved coding region present in all completely sequenced ascovirus members, was characterized in this study. By RT-PCR detection, 3h-117 transcription began at 6-h post-infection (hpi) and remained stable until 168 hpi in HvAV-3h-infected Helicoverpa ar...
Yun, B.G. Lee, S.-H. Jeon, J.H. Kim, S.-W. Jung, C.K. Park, G. Kim, S.Y. Jeon, S. Lee, M.S. Park, S.H.
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Stem cell transplantation is a promising therapeutic strategy that includes both cell therapy and tissue engineering for the treatment of many regenerative diseases; however, the efficacy and safety of stem cell therapy depend on the cell type used in therapeutic and translational applications. In this study, we validated the hypothesis that human ...
Játiva, Soraya Calabria, Ines Moyano-Rodriguez, Yolanda Garcia, Patricia Queralt, Ethel
Published in
Cellular and molecular life sciences : CMLS
Exit from mitosis and completion of cytokinesis require the inactivation of mitotic cyclin-dependent kinase (Cdk) activity. In budding yeast, Cdc14 phosphatase is a key mitotic regulator that is activated in anaphase to counteract Cdk activity. In metaphase, Cdc14 is kept inactive in the nucleolus, where it is sequestered by its inhibitor, Net1. At...
Washburn, Alex Abdeen, Sanofar Ovechkina, Yulia Ray, Anne-Marie Stevens, Mckayla Chitre, Siddhi Sivinski, Jared Park, Yangshin Johnson, James Hoang, Quyen Q
...
Published in
Bioorganic & medicinal chemistry letters
Current treatments for Mycobacterium tuberculosis infections require long and complicated regimens that can lead to patient non-compliance, increasing incidences of antibiotic-resistant strains, and lack of efficacy against latent stages of disease. Thus, new therapeutics are needed to improve tuberculosis standard of care. One strategy is to targe...
Gil, Raquel Sales Vagnarelli, Paola
Published in
Biochimica et biophysica acta. Molecular cell research
Chromatin structure and dynamics are highly controlled and regulated processes that play an essential role in many aspects of cell biology. The chromatin transition stages and the factors that control this process are regulated by post-translation modifications, including phosphorylation. While the role of protein kinases in chromatin dynamics has ...