Ting, Kay Reen Ong, Pei Yi Wei, Samuel Ow Guan Parameswaran, Rajeev Khoo, Chin Meng Deepak, Doddabele Srinivasa Lee, Soo-Chin
Published in
Hereditary Cancer in Clinical Practice
BackgroundHereditary paraganglioma (PGL) and pheochromocytoma (PCC) syndromes are rare conditions, with limited data on spectrum of causative gene variants of these syndromes in Asian patients.MethodsWe describe the clinical characteristics and genetic testing outcomes of patients with suspected hereditary PGL/PCC who were referred to a tertiary ca...
Seo, Soo Hyun Kim, Jung Hee Kim, Man Jin Cho, Sung Im Kim, Su Jin Kang, Hyein Shin, Chan Soo Park, Sung Sup Lee, Kyu Eun Seong, Moon-Woo
...
Published in
Endocrinology and metabolism (Seoul, Korea)
Pheochromocytoma and paragangliomas (PPGL) are known as tumors with the highest level of heritability, approximately 30% of all cases. Clinical practice guidelines of PPGL recommend genetic testing for germline variants in all patients. In this study, we used whole exome sequencing to identify novel causative variants associated with PPGL to improv...
Choi, Heewon Kim, Kyoung Jin Hong, Namki Shin, Saeam Choi, Jong-Rak Kang, Sang Wook Lee, Seung Tae Rhee, Yumie
Published in
Endocrinology and metabolism (Seoul, Korea)
Pheochromocytoma and paragangliomas (PPGL) are hereditary in approximately 30% to 40% cases. With the advancement of genetic analysis techniques, including next-generation sequencing (NGS), there were attempts to classify PPGL into molecular clusters. With NGS being applied to clinical settings recently, we aimed to review the results of genetic an...
Yang, Yanliang Wang, Guangzhi Lu, Haofeng Liu, Yaqing Ning, Shili Luo, Fuwen
Published in
BMC Surgery
BackgroundParagangliomas (PGLs) are extremely rare neuroendocrine tumours arising from extra-adrenal chromaffin cells. PGLs are clinically rare, difficult to diagnose and usually require surgical intervention. PGLs mostly present catecholamine-related symptoms. We report a case of Acute abdomen as the initial manifestation of haemorrhagic retroperi...
Kong, Hao Yang, Jiao-Nan Tian, Jie Li, Nan Zhang, Yu-Xiu Ye, Peng-Cheng Li, Xue-Ying Zhang, Zheng
Published in
BMC Anesthesiology
BackgroundPreoperative intravenous rehydration for patients with pheochromocytomas and paragangliomas (PPGLs) is widely used in many medical centers, but its usefulness has not been well evaluated. The objective of this study was to compare the perioperative hemodynamics and early outcome between patients who received preoperative intravenous rehyd...
Nam, Jong-Ho Park, Jong-Seon Choi, Joon Hyuk
Published in
BMC Cardiovascular Disorders
BackgroundParagangliomas are tumors that arise from extra-adrenal chromaffin cells. Herein, we present a rare case of a functional paraganglioma in the posterior mediastinum.Case presentationA 36-year-old man presented with paroxysms of chest pain and headache. At presentation, the patient’s blood pressure was 190/120 mmHg. Chest computed tomograph...
Cagney, David Hanrahan, Michael Razzaq, Zeeshan Majeed, Mudassar O'Leary, Donal Peter Redmond, Henry Paul
Published in
Irish journal of medical science
Laparoscopic transperitoneal and retroperitoneoscopic adrenalectomy have largely replaced open adrenal surgery, particularly in benign disease. Laparoscopic surgery results in less post-operative pain, fewer surgical site complications and reduced length of hospital stay. The aim of this retrospective study was to analyse the characteristics of pat...
Kong, Hao Li, Nan Tian, Jie Bao, Zhengqing Liu, Lu Wu, Kai Gao, Ying Jin, Bo Zhang, Zheng Fang, Dong
...
Published in
International urology and nephrology
No conclusion exists for the optimum duration of preoperative administration of doxazosin (DOX) before adrenalectomy for pheochromocytoma. The purpose of this study is to investigate whether perioperative hemodynamics and postoperative outcomes are related to the duration of DOX administration. In total, 132 patients managed preoperatively with sin...
de Silva, Taniya Cosentino, Gina Ganji, Suneeta Riera-Gonzalez, Alejandra Hsia, Daniel S.
Published in
Current Hypertension Reports
Purpose of ReviewTo discuss selected endocrine causes of hypertension and to provide practical clinical recommendations regarding the evaluation and treatment of these disorders.Recent FindingsMore than 15 endocrine disorders with varying rates of prevalence can cause hypertension. For example, primary aldosteronism may exist in up to 20% of patien...
Mitra, Anirban P. Vasquez, Evalynn Kokorowski, Paul Chang, Andy Y.
Published in
BMC Urology
BackgroundLaparoscopic resection is the most well described minimally-invasive approach for adrenalectomy. While it allows for improved cosmesis, faster recovery and decreased length of hospital stay compared with the open approach, instrument articulation limitations can hamper surgical dexterity in pediatric patients. Use of robotic assistance ca...
