Polypharmacy is associate with serious drug event as hospitalizations or falls. Prescribingcascades contribute to polypharmacy by increasing the burden of inappropriate medications.A prescribing cascade occur when a drug is prescribed to treat an unrecognized adversedrug event caused by a previously prescribed drug. Nine clinically important prescr...
Published in Pediatric nephrology (Berlin, Germany)
The objective of this report is to identify and characterize cases of fibrosing colonopathy, a rare and underrecognized adverse event, associated with cysteamine delayed-release (DR) in patients with nephropathic cystinosis. We searched the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) and the medical literature for postm...
La vaccination n'augmente pas le risque d'anémie immunologique chez le chien, même si elle doit être prise en compte lors du diagnostic de ce type d'affection. La mise en place d'un traitement immunosuppresseur implique une adaptation du calendrier et des protocoles vaccinaux. Il est recommandé de mettre à jour les vaccinations avant le début du tr...
Published in Expert opinion on drug safety
Daratumumab is widely used in multiple myeloma (MM) and light chain amyloidosis (AL amyloidosis). The purpose of this study was to identify adverse event (AE) signals for daratumumab through the FDA Adverse Event Reporting System (FAERS) database to assess its safety in a large sample of people. Based on data from the FAERS database, three dispropo...
Published in Expert opinion on drug safety
This study aimed to adopt the conventional signal detection methods to explore a new way of risk identification and to mine important drug risks from the perspective of big data based on Zhenjiang Adverse Event Reporting System (ZAERS). Data were extracted from ZAERS database between 2012 and 2022. The risks of all the reported drug event combinati...
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Farmácia. / A farmacovigilância monitora a segurança dos medicamentos após a comercialização. Este campo ganhou relevância após o desastre da Talidomida em 1961, que levou à criação do Programa Internacional de Monitorização de Medicamentos pela Organização Mundi...
Les effets indésirables et les événements indésirables graves liés aux soins (EIGS) constituent deux facteurs majeurs d’hospitalisation ou de prolongation d’hospitalisation pouvant conduire au décès. Il est crucial de les prévenir. Le pharmacien, en raison de sa proximité avec les usagers et de son implication dans le circuit du médicament, doit êt...
Published in Schizophrenia research
There is growing interest in clozapine clinical use, monitoring, and research, particularly adverse drug reactions (ADRs) other than agranulocytosis. In this study we focused on clozapine pharmacovigilance. Hence, we contacted clinicians and researchers in Latin America and requested information about local psychiatric services, clozapine availabil...
Published in Schizophrenia research
After the introduction of clozapine eight Finnish patients died after developing agranulocytosis. Clozapine was withdrawn from the market and only reintroduced with strict mandatory white blood cell monitoring as long as treatment lasts and thresholds at which clozapine must be discontinued definitively. The fear of agranulocytosis and the need for...
La pharmacovigilance a pour but la sécurité des patients. Ce guide oriente le processus de pharmacovigilance au sein du CHU.Il explique clairement le rôle de chaque acteur qui devrait être impliqué dans le processus de pharmacovigilance. Ce guide a été élaboré pour faciliter la décentralisation de la pharmacovigilance au sein du CHU. Il répond au b...
