Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTMPK) for the synthesis of thymidine triphosphates and thus also DNA synthesis. Therefore, this enzyme constitutes a potential Achilles heel of the pathogen. Based on a previously reported MtbTMPK 6-aryl-substituted pyridone inhibitor and guided by two...
Published in Bulletin of the National Research Centre
Strobilanthes kunthiana (Nees) T. Anderson ex Benth locally known as Neelakurinji is an endemic to Western Ghat, India and belongs to the Acanthaceae family. It has a unique flowering pattern to bloom every 12 years. The objective of this review is to highlight the taxonomy, distribution, ecology, biology, pharmacological properties, and conservati...
Aims Hypertension is a major contributor to cardiac diastolic dysfunction. Different therapeutics strategies have been proposed to control blood pressure (BP), but their independent impact on cardiac function remains undetermined. In patients with resistant hypertension, we compared the changes in cardiac parameters between two strategies based on ...
Published in BMC Complementary Medicine and Therapies
BackgroundAfrican Potato (hypoxis hemerocallidea), is used for enhancing immune system in Southern Africa. It is among the plants of intense commercial and scientific interest; hence, the aim of this study was to describe its chemistry and pharmacology.MethodsPubMed, Cochrane Controlled Trials Register (CENTRAL) and Google Scholar were searched ind...
Published in Heliyon
Biochemistry; Toxicology; Pharmaceutical chemistry; Pharmacology; Oncology; Hepatocellular carcinoma; Metabolism; HepG2 cells; Ruthenium complex; HeLa cells: Cell respiration
Published in Scientific Reports
Lipidised analgesic peptide prodrugs self-assemble into peptide nanofibers; with the nanofiber morphology protecting the peptide from plasma degradation and improving therapeutic efficacy. Extending this learning, we hypothesised that a self-assembling lipidized peptide arginine vasopressin (AVP) receptor agonist, that had not been designed as a pr...
Background:The selective occurrence of hepatotoxicity observed with use of pazopanib may be attributed to its high level of plasma protein binding and low hepatic extraction ratio. The primary objective was to investigate changes in free drug concentration amongst patients with varying albumin concentrations. Methods:A HPLC-MS/MS method using C18 c...
Published in Journal of Dental Anesthesia and Pain Medicine
Background The international organization for standardization (ISO) 80601-2-61 dictates that the accuracy of a pulse oximeter should be assessed by a controlled desaturation study. We aimed to characterize the relationship between the fraction of inspired oxygen (FiO2) and peripheral oxygen saturation (SpO2) using a turnover model by retrospectivel...
Published in Heliyon
Cancer surgery; Clinical research; Dental surgery; Dentistry; Oral medicine; Pharmacology; Antiresorptive agents; Drug holiday; Holidays; MRONJ; Osteonecrosis of the jaw; Oral surgery; Tooth extraction.
Published in Heliyon
Pazopanib; Plasma free drug concentration; Fraction unbound; Liquid chromatography-tandem mass spectrometry; Equilibrium dialysis; Pharmacology; Clinical toxicology; Oncology; Evidence-based medicine; Clinical research.
