Zhang, Wen-Jin Zhao, Zhen-Yu Chang, Li-Kun Cao, Ye Wang, Sheng Kang, Chuan-Zhi Wang, Hong-Yang Zhou, Li Huang, Lu-Qi Guo, Lan-Ping
...
Published in
Journal of ethnopharmacology
Atractylodis Rhizoma (AR), mainly includes Atractylodes lancea (Thunb.) DC. (A. lancea) and Atractylodes chinensis (DC.) Koidz. (A. chinensis) is widely used in East Asia as a diuretic and stomachic drug, for the treatment of rheumatic diseases, digestive disorders, night blindness, and influenza as it contains a variety of sesquiterpenoids and oth...
Augustynowicz, Daniel Latté, Klaus Peter Tomczyk, Michał
Published in
Journal of ethnopharmacology
Potentilla plants are still common herbal medicines used in folk medicine. This review provides an update of research undertaken on Potentilla from 2009 until 2020. This comprehensive review considers biological updates, recent advances in phytochemical and pharmacological research, and toxicological reports on Potentilla sensu lato based on availa...
Zhu, Wenbo Wang, Zhibin Sun, Yanping Yang, Bingyou Wang, Qiuhong Kuang, Haixue
Published in
Journal of ethnopharmacology
Genus Syringa, which belongs to Oleaceae family, contains 21 accepted species mainly distributed in Southeast Europe, Japan, China, Himalayas, etc. The various parts of Syringa species have been used as traditional Chinese herbal medicines for treatment of cough, myocardial ischemia, acute icteric hepatitis, diarrhea, conjunctivitis, bronchitis and...
Yan, Yu-Dong Chen, Yu-Qing Wang, Chen-Yao Ye, Chen-Bo Hu, Zhen-Zhen Behnisch, Thomas Huang, Zhi-Li Yang, Su-Rong
Published in
Translational Psychiatry
Depression, cognitive deficits, and sleep disturbances are common and often severe in menopausal women. Hormone replacement cannot effectively alleviate these symptoms and sometimes elicits life-threatening adverse reactions. Exploring effective therapies to target psychological problems is urgently needed. In this work, we developed a mouse model ...
Chakrabarti, Srijita Mazumder, Bhaskar Rajkonwar, Jadab Pathak, Manash Pratim Patowary, Pompy Chattopadhyay, Pronobesh
Published in
Scientific Reports
Burn injuries are most challenging to manage since it causes loss of the integrity of large portions of the skin leading to major disability or even death. Over the years, hydrogels are considered as a significant delivery system for wound treatment because of several advantages over other conventional formulations. We hypothesized that the bFGF-co...
Elam, Hannah B. Perez, Stephanie M. Donegan, Jennifer J. Lodge, Daniel J.
Published in
Translational Psychiatry
Post-traumatic stress disorder (PTSD) is a prevalent condition affecting approximately 8% of the United States population and 20% of United States combat veterans. In addition to core symptoms of the disorder, up to 64% of individuals diagnosed with PTSD experience comorbid psychosis. Previous research has demonstrated a positive correlation betwee...
McHugh, Douglas Yanik, Andrew J. Mancini, Michael R.
Published in
BMC Medical Education
BackgroundOngoing developments in medical education recognize the move to curricula that support self-regulated learning processes, skills of thinking, and the ability to adapt and navigate uncertain situations as much as the knowledge base of learners. Difficulties encountered in pursuing this reform, especially for pharmacology, include the tende...
Weisell, Jonna Ruotsalainen, Anna-Kaisa Näpänkangas, Juha Jauhiainen, Matti Rysä, Jaana
Published in
Scientific Reports
In calcific aortic valve disease (CAVD) progressive valvular calcification causes aortic valve dysfunction. CAVD has several risk factors such as age and dyslipidemia. Vitamin K was shown to inhibit vascular calcification in mice and valvular calcification in patients with CAVD. We studied the effect of menaquinone 4 (MK4/vitamin K2) on valvular ca...
Lin, Zhong Chen, Dan-yang Zhu, Yan-Wu Jiang, Zheng-li Cui, Ke Zhang, Sheng Chen, Li-hua
Published in
Scientific Reports
Management of vancomycin administration for intensive care units (ICU) patients remains a challenge. The aim of this study was to describe a population pharmacokinetic model of vancomycin for optimizing the dose regimen for ICU patients. We prospectively enrolled 466 vancomycin-treated patients hospitalized in the ICU, collected trough or approach ...
Sougiannis, Alexander T. Enos, Reilly T. VanderVeen, Brandon N. Velazquez, Kandy T. Kelly, Brittany McDonald, Sierra Cotham, William Chatzistamou, Ioulia Nagarkatti, Mitzi Fan, Daping
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Published in
BMC Pharmacology and Toxicology
BackgroundEmodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surrounding its potential toxicity. The primary purpose of this study was to uncover any potential toxic properties of emodin in mice at d...
