Published in Naunyn-Schmiedeberg's archives of pharmacology
Envenomation is a common medical problem. The Canon of Medicine written by Avicenna is one of the reliable sources of Persian medicine. The present study aims to identify Avicenna's clinical pharmacology approach and the pharmacopeia used for the treatment of animal envenomations and also to evaluate the related data in light of the current medicin...
Published in Archives of disease in childhood. Education and practice edition
A linfadenite caseosa (LC) é uma doença infectocontagiosa causada pela bactéria Corynebacterium pseudotuberculosis. O tratamento convencional é a drenagem cirúrgica do abscesso e cauterização química com tintura de iodo a 10%, que é caro (mão de obra e materiais), laborioso e apresenta uma baixa biosseguridade. Nesse contexto, decidiu-se validar um...
Published in Psychopharmacology
Fear conditioning is an important aspect in the pathophysiology of anxiety disorders. The fear-potentiated startle test is based on classical fear conditioning and over the years, a broad range of drugs have been tested in this test. Synthesis of the available data may further our understanding of the neurotransmitter systems that are involved in t...
Published in BMJ paediatrics open
This study aims: (a) to evaluate patterns of domperidone dispensing to mothers of very preterm (
Objective: Patients with factitious disorder imposed on self (FDIS) seek medical care for deliberately falsified problems. Although a large amount of work has been published, the scientific literature lacks robust data on FDIS. The present study aimed to estimate the annual mean of in-hospital FDIS codings in France, describe the sociodemographic c...
The physiological significance of metabotropic acetylcholine receptors in parasitic nematodes remains largely unexplored. Here, three different Trichinella spiralis G protein-coupled acetylcholine receptors (TsGAR-1, -2, and -3) were identified in the genome of T. spiralis. The phylogenetic analyses showed that TsGAR-1 and -2 receptors belong to a ...
Published in Biochemical pharmacology
Pancreatic cancer is highly metastatic and lethal with an increasing incidence globally and a 5-year survival rate of only 8%. One of the factors contributing to the high mortality is the lack of effective drugs in the clinical setting. We speculated that effective compounds against pancreatic cancer exist in natural herbs and explored active small...
Published in Frontiers for Young Minds
What is difficult about creating a new drug? In recent times, developing a new drug is based on understanding the specific processes of the disease the drug is meant to treat. However, this was not always the case. Drugs used to be discovered by a trial-and-error process, in which chemists tinkered with chemicals and hoped for success. How did we m...
Abstract Voriconazole is a triazole antifungal indicated for invasive fungal infections that exhibits high degree of inter-individual and intra-individual pharmacokinetic variability. pharmacokinetics non-linear, making dosage adjustments more difficult. Therapeutic drug monitoring recommended by measurement minimum plasma concentrations. Several f...
