peer reviewed / Despite its small size, Belgium has a dynamic and innovative healthcare framework, rich in initiatives and sources of inspiration for other countries. An analysis of the Belgian healthcare system highlights the central role of the pharmacist and the specific advances made by this front-line profession.
Published in British journal of sports medicine
To compare the efficacy of exercise, metformin and their combination on glucose metabolism in individuals with abnormal glycaemic control. Systematic review and network meta-analysis. Embase, Web of Science, PubMed/MEDLINE and SPORTDiscus. Randomised controlled trials involving exercise, metformin or their combined treatments in individuals with pr...
Published in Naunyn-Schmiedeberg's archives of pharmacology
Oswald Schmiedeberg was born in one of the former Baltic provinces of Russia. He studied medicine in Dorpat (Tartu) and joined the Institute of Pharmacology of Rudolf Buchheim in Dorpat. After promotion (1866) and habilitation (1868), he succeeded Buchheim as director of the institute. During this time, he further developed the experimental methods...
Published in Computational and Structural Biotechnology Journal
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Published in Naunyn-Schmiedeberg's archives of pharmacology
Bruceines A-L are among the quassinoid representatives found in the medicinal plant Brucea javanica (L.). An overview of their pharmacological activities is still unknown. The given research deals with highlights in their pharmacological result, molecular mechanism of action, synthetic progress, and pharmacokinetics. From previous evidence, brucein...
Published in Journal of clinical monitoring and computing
Post-induction hypotension (MAP
Published in Purinergic signalling
There is growing interest in the P2X4 receptor as a therapeutic target for several cardiovascular, inflammatory and neurological conditions. Key to exploring the physiological and pathophysiological roles of P2X4 is access to selective compounds to probe function in cells, tissues and animal models. There has been a recent growth in selective antag...
Published in Regional anesthesia and pain medicine
Chat Generative Pre-trained Transformer (ChatGPT), an artificial intelligence chatbot, produces detailed responses and human-like coherent answers, and has been used in the clinical and academic medicine. To evaluate its accuracy in regional anesthesia topics, we produced a ChatGPT review on the addition of dexamethasone to prolong peripheral nerve...
peer reviewed / Hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG) are protoxins produced by Sapindaceae plants, particularly Acer pseudoplatanus, and are responsible for causing atypical myopathy (AM) in equids. These protoxins metabolise into toxic compounds, such as methylenecyclopropylacetyl-CoA (MCPA-CoA), which alters energy metabolis...
Published in BMC medicine
Drug target Mendelian randomization describes the use of genetic variants as instrumental variables for studying the effects of pharmacological agents. The paradigm can be used to inform on all aspects of drug development and has become increasingly popular over the last decade, particularly given the time- and cost-efficiency with which it can be ...
