Nasiri, Ebrahim Orimi, Jamal Rezaei Aghabeiglooei, Zahra Walker-Meikle, Kathleen Amrollahi-Sharifabadi, Mohammad
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Envenomation is a common medical problem. The Canon of Medicine written by Avicenna is one of the reliable sources of Persian medicine. The present study aims to identify Avicenna's clinical pharmacology approach and the pharmacopeia used for the treatment of animal envenomations and also to evaluate the related data in light of the current medicin...
Wyness, Benjamin Crook, Joanne D'Silva, Pam McCormick, David
Published in
Archives of disease in childhood. Education and practice edition
SOUSA, N. P. LIMA, A. M. C. ARAÚJO, J. B. de ANDRADE, I. M. FERRANTE, M. FACCIOLI-MARTINS, P. Y.
A linfadenite caseosa (LC) é uma doença infectocontagiosa causada pela bactéria Corynebacterium pseudotuberculosis. O tratamento convencional é a drenagem cirúrgica do abscesso e cauterização química com tintura de iodo a 10%, que é caro (mão de obra e materiais), laborioso e apresenta uma baixa biosseguridade. Nesse contexto, decidiu-se validar um...
Groenink, Lucianne Verdouw, P Monika Zhao, Yulong Ter Heegde, Freija Wever, Kimberley E Bijlsma, Elisabeth Y
Published in
Psychopharmacology
Fear conditioning is an important aspect in the pathophysiology of anxiety disorders. The fear-potentiated startle test is based on classical fear conditioning and over the years, a broad range of drugs have been tested in this test. Synthesis of the available data may further our understanding of the neurotransmitter systems that are involved in t...
McBride, Grace McKenzie Rumbold, Alice R Keir, Amy K Kunnel, Aline Buxton, Michael Jones, Susanne Summers, Laura Stark, Michael Grzeskowiak, Luke E
Published in
BMJ paediatrics open
This study aims: (a) to evaluate patterns of domperidone dispensing to mothers of very preterm (
Berar, Antoine Balusson, Frederic Allain, Jean-Sébastien
Objective: Patients with factitious disorder imposed on self (FDIS) seek medical care for deliberately falsified problems. Although a large amount of work has been published, the scientific literature lacks robust data on FDIS. The present study aimed to estimate the annual mean of in-hospital FDIS codings in France, describe the sociodemographic c...
Ning, Caina Heckmann, Aurélie Mateos-Hernández, Lourdes Karadjian, Grégory Šimo, Ladislav
The physiological significance of metabotropic acetylcholine receptors in parasitic nematodes remains largely unexplored. Here, three different Trichinella spiralis G protein-coupled acetylcholine receptors (TsGAR-1, -2, and -3) were identified in the genome of T. spiralis. The phylogenetic analyses showed that TsGAR-1 and -2 receptors belong to a ...
Qi, Jindan Meng, Mei Liu, Juntao Song, Xiaoxiao Chen, Yu Liu, Yuxi Li, Xu Zhou, Zhou Huang, Xiang Wang, Xiaohua
...
Published in
Biochemical pharmacology
Pancreatic cancer is highly metastatic and lethal with an increasing incidence globally and a 5-year survival rate of only 8%. One of the factors contributing to the high mortality is the lack of effective drugs in the clinical setting. We speculated that effective compounds against pancreatic cancer exist in natural herbs and explored active small...
Ochi, Taichi Hak, Eelko
Published in
Frontiers for Young Minds
What is difficult about creating a new drug? In recent times, developing a new drug is based on understanding the specific processes of the disease the drug is meant to treat. However, this was not always the case. Drugs used to be discovered by a trial-and-error process, in which chemists tinkered with chemicals and hoped for success. How did we m...
Boglione-Kerrien, Christelle Zerrouki, Sélim Le Bot, Audrey Camus, Christophe Marchand, Tony Bellissant, Eric Tron, Camille Verdier, Marie-Clémence Gangneux, Jean-Pierre Lemaitre, Florian
...
Abstract Voriconazole is a triazole antifungal indicated for invasive fungal infections that exhibits high degree of inter-individual and intra-individual pharmacokinetic variability. pharmacokinetics non-linear, making dosage adjustments more difficult. Therapeutic drug monitoring recommended by measurement minimum plasma concentrations. Several f...