Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatment...
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Faculty
Madness and Text: The Psychiatric Paper as a Business and as a Means of Censorship
Las revistas son básicamente el único canal a través del cual los científicos pueden hacer que el resultado de su investigación sea conocido por sus colegas. Las revistas científicas seleccionan la información que publican y garantizan su calidad mediante un procedimiento doble ciego de censura por parte de sus pares. Si por un lado este procedimie...
Novel Distinct Roles for Intestinal/Macrophage COX-2 and Apolipoprotein Mimetic Peptides in the Development and Treatmen...
Cyclooxygenase 2 (COX2) has been associated with the development of inflammatory bowel disease (IBD), but the nature of this association has remained unclear. I demonstrate that mice that lack COX2 lose tolerance to pathogen associated molecular patterns. Thus, challenge with dietary cholate—an environmental trigger that I show impairs intestinal b...
Liver injury with direct-acting anticoagulants: has the fog cleared?
Published in Heart (British Cardiac Society)
A versatile optical tool for studying synaptic GABAA receptor trafficking.
...Published in Journal of cell science
Live-cell imaging methods can provide critical real-time receptor trafficking measurements. Here, we describe an optical tool to study synaptic γ-aminobutyric acid (GABA) type A receptor (GABAAR) dynamics through adaptable fluorescent-tracking capabilities. A fluorogen-activating peptide (FAP) was genetically inserted into a GABAAR γ2 subunit tagge...
Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine.
Published in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Novel developments in biomarkers discovery are essential in modern health care, notably in treatment individualization and precision medicine. Clinical metabolomics, which aims to identify small molecule metabolites present in patient-derived samples, has attracted much attention to support discovery of novel biomarkers. However, the step from disc...
PCSK9 inhibition and atherosclerotic cardiovascular disease prevention: does reality match the hype?
Published in Heart (British Cardiac Society)
Within this review we look at whether the potential provided by proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition for prevention of atherosclerotic cardiovascular disease matches the excitement generated. Two fully human monoclonal antibodies to PCSK9 are currently licenced for clinical use both in the USA and the European Union: evo...
A new Drosophila octopamine receptor responds to serotonin.
Published in Insect biochemistry and molecular biology
As the counterparts of the vertebrate adrenergic transmitters, octopamine and tyramine are important physiological regulators in invertebrates. They control and modulate many physiological and behavioral functions in insects. In this study, we reported the pharmacological properties of a new α2-adrenergic-like octopamine receptor (CG18208) from Dro...
Dihydrosanguinarine Enhances Glucose Uptake in Mouse 3T3-L1 Cells
Recently, more studies have aimed at identifying selective peroxisome proliferator-activated receptor gamma (PPARγ) modulators that transactivate the expression of PPARγ-dependent genes as partial agonists to improve diabetic symptoms with fewer side effects compared to classic PPARγ agonists such as thiazolidinediones. We found that dihydrosanguin...
Dihydrosanguinarine Enhances Glucose Uptake in Mouse 3T3-L1 Cells
Recently, more studies have aimed at identifying selective peroxisome proliferator-activated receptor gamma (PPARγ) modulators that transactivate the expression of PPARγ-dependent genes as partial agonists to improve diabetic symptoms with fewer side effects compared to classic PPARγ agonists such as thiazolidinediones. We found that dihydrosanguin...
