Sanchez-Lopez, Alvaro De Raedt, Rudi Puttevils, Louise Koster, Ernst H W Baeken, Chris Vanderhasselt, Marie-Anne
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Low resilience is characterized by impairments in attention and emotion regulation mechanisms that depend on prefrontal cortical activity. The aim of this study was to test whether transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) can augment the effectiveness of a new computerized mouse-based (gaze...
Sonne, Nina Karsdal, Morten A Henriksen, Kim
Published in
Molecular metabolism
Therapies for metabolic diseases are numerous, yet improving insulin sensitivity beyond that induced by weight loss remains challenging. Therefore, search continues for novel treatment candidates that can stimulate insulin sensitivity and increase weight loss efficacy in combination with current treatment options. Calcitonin gene-related peptide (C...
Sajjad, Sehrish Gowani, Ambreen
Published in
British journal of nursing (Mark Allen Publishing)
Flipped classroom pedagogy has been shown to improve nursing students' academic performance. The study aimed to determine the effect of a flipped classroom approach on students' pharmacology assessment scores in a school of nursing in Karachi, Pakistan. A retrospective chart review was performed. The pharmacology test scores of the BSc nursing coho...
Feng, Sen Ling Zhang, Jing Jin, Hongliu Zhu, Wen Ting Yuan, Zhongwen
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background This network pharmacology study aimed to identify the active compounds and molecular mechanisms involved in the effects of Hypericum japonicum on cholestatic hepatitis. We validated the findings in an alpha-naphthylisothiocyanate (ANIT) rat model of hepatotoxicity. Material/Methods The chemical constituents and targets of H. japonicum an...
Barootes, Hailey C. Peebles, Erin R. Matsui, Doreen Rieder, Michael Abuzgaia, Awatif Mohammed, Javed A.
Published in
Case Reports in Dermatology
Generalized bullous fixed drug eruptions (GBFDEs) are rare in the paediatric population. We present the case of a 7-year-old girl with GBFDE believed to be secondary to oral ibuprofen, who experienced rapid resolution of lesions and cessation of blistering with a 3-week course of oral cyclosporine. To the best of our knowledge, this is the first re...
Askari, Sayyedeh Fatemeh Avan, Razieh Tayarani-Najaran, Zahra Sahebkar, Amirhossein Eghbali, Samira
Published in
Phytochemistry
Salvia is the largest genus of the Lamiaceae family, with over 900 species in the world which about 60 species are distributed in Iran, 17 of them are endemic. In Iran, Salvia species have been used to treat various diseases with a wide spectrum of pharmacological activity in vitro and in vivo. The present review summarizes the phytochemistry and p...
Balan, Irina Aurelian, Laure Schleicher, Riana Boero, Giorgia O’Buckley, Todd Morrow, A. Leslie
Published in
Translational Psychiatry
We have shown that endogenous neurosteroids, including pregnenolone and 3α,5α-THP inhibit toll-like receptor 4 (TLR4) signal activation in mouse macrophages and the brain of alcohol-preferring (P) rat, which exhibits innate TLR4 signal activation. The current studies were designed to examine whether other activated TLR signals are similarly inhibit...
Nishi, Akinori Kaifuchi, Noriko Shimobori, Chika Ohbuchi, Katsuya Iizuka, Seiichi Sugiyama, Aiko Ogura, Keisuke Yamamoto, Masahiro Kuroki, Haruo Nabeshima, Shigeki
...
Published in
Scientific Reports
Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasal...
Lago, Santiago G. Tomasik, Jakub Bahn, Sabine
Published in
Translational Psychiatry
Mental health disorders are a leading cause of disability worldwide. Challenges such as disease heterogeneity, incomplete characterization of the targets of existing drugs and a limited understanding of functional interactions of complex genetic risk loci and environmental factors have compromised the identification of novel drug candidates. There ...
Rodriguez, Steve Hug, Clemens Todorov, Petar Moret, Nienke Boswell, Sarah A. Evans, Kyle Zhou, George Johnson, Nathan T. Hyman, Bradley T. Sorger, Peter K.
...
Published in
Nature Communications
Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have provided largely negative results, so far. Here, the authors present a machine learning framework that quantifies potential associations between the pathology of AD severity and gene-based molecular mechanisms to enable drug repurposing.
