Yang, Chengxi Li, Peng Ding, Xiaoli Sui, Hao Chen Rao, Shun Hsu, Chia-Hsiang Leung, Wing-Por Cheng, Gui-Juan Wang, Pan Zhu, Bao Ting
...
Published in
Scientific Reports
It has been known for many years that the peroxidase activity of cyclooxygenase 1 and 2 (COX-1 and COX-2) can be reactivated in vitro by the presence of phenol, which serves as a reducing compound, but the underlying mechanism is still poorly understood. In the present study, we use phenol as a model compound to investigate the mechanism by which t...
Kola-Mustapha, A.T. Yohanna, K.A. Ghazali, Y.O. Ayotunde, H.T.
Published in
Heliyon
Pain; Inflammation; Polyherbal; Carbopol Gel; Chasmanthera Dependens; Chenopodium Ambrosioides; Biological Sciences; Plant Biology; Pharmaceutical Science; Health Sciences; Pharmacology; Alternative Medicine.
Chowdhury, Md. Riad Chowdhury, Kamrul Hasan Hanif, Nujhat Binte Sayeed, Mohammed Abu Mouah, Jannatul Mahmud, Iftekher Kamal, A.T.M. Mostafa Chy, Md. Nazim Uddin Adnan, Md.
Published in
Heliyon
Bischofia javanica ; sedative and anxiolytic; Anti-diabetic; Thrombolytic; Cytotoxic; Molecular docking; Bioinformatics; Evidence-Based Medicine; Neuroscience; Pharmaceutical Science; Pharmacology; Toxicology
Zhan, Xiping Dowell, Sharon Shen, Ying Lee, Dexter L.
Published in
Heliyon
Chloroquine, Hydroxychloroquine, Calcium, HCN, SARS-CoV-2; Cardiology; Pathology; Infectious disease; Neurology; Pharmacology; Immunology; Clinical toxicology; Toxicology; Eye-ear-nose-throat; Internal medicine
Malami, Ibrahim Jagaba, Nasiru Muhammad Abubakar, Ibrahim Babangida Muhammad, Aliyu Alhassan, Alhassan Muhammad Waziri, Peter Maitama Yakubu Yahaya, Ibrahim Zakiyya Mshelia, Halilu Emmanuel Mathias, Sylvester Nefy
Published in
Heliyon
Alternative medicine; Cancer research; Ethnopharmacology; Pharmaceutical science; Pharmacology; Traditional medicine practice; Cancer; Integrative medicine; Medicinal plants; Ethnobotanical survey; Sokoto state
Jones-Tabah, Jace Mohammad, Hanan Hadj-Youssef, Shadi Kim, Lucy E. H. Martin, Ryan D. Benaliouad, Faïza Tanny, Jason C. Clarke, Paul B. S. Hébert, Terence E.
Published in
Scientific Reports
As with many G protein-coupled receptors (GPCRs), the signalling pathways regulated by the dopamine D1 receptor (D1R) are dynamic, cell type-specific, and can change in the face of disease or drug exposures. In striatal neurons, the D1R activates cAMP/protein kinase A (PKA) signalling. However, in Parkinson’s disease (PD), alterations in this pathw...
Ben Ahmed, Ziyad Yousfi, Mohamed Viaene, Johan Dejaegher, Bieke Demeyer, Kristiaan Heyden, Yvan Vander
Published in
Journal of ethnopharmacology
Pistacia atlantica (wild pistachio) belongs to the Anacardiaceae family, and growing from the Mediterranean basin to central Asia, especially in Iran, Turkey, Iraq and Saudi Arabia where it is extensively used in traditional medicine for a wide range of ailments related to relieving upper abdominal discomfort and pain, dyspepsia and peptic ulcer. D...
Pitchai, Arjun Rajaretinam, Rajesh Kannan Mani, Rajasekar Nagarajan, Nagasundaram
Published in
Heliyon
Alzheimer's disease (AD), a neurodegenerative disorder affects more than 35 million people globally. Acetylcholinesterase suppression is the common approach to enhance the well-being of AD patients by increasing the duration of acetylcholine in the cholinergic synapses. Generally, herbal secondary metabolites are reported to be a major resource for...
Jian, Yanlin Hulpia, Fabian Risseeuw, Martijn Forbes, He Eun Munier-Lehmann, Hélène Caljon, Guy Boshoff, Helena I. M. Van Calenbergh, Serge
Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTMPK) for the synthesis of thymidine triphosphates and thus also DNA synthesis. Therefore, this enzyme constitutes a potential Achilles heel of the pathogen. Based on a previously reported MtbTMPK 6-aryl-substituted pyridone inhibitor and guided by two...
Yu, Han Li, Ting-Na Ran, Qian Huang, Qin-Wan Wang, Jin
Published in
Journal of ethnopharmacology
Strobilanthes cusia (Nees) Kuntze (SCK, Malan), a traditional Chinese medicinal plant, has long applied to detoxification, defervescence, detumescence and antiphlogosis. "Southern Banlangen" (Rhizoma et Radix Baphicacanthis Cusiae, RRBC), root and rhizome of SCK, is widely used for treatment of many epidemic diseases. Malanye (Southern Daqingye), s...
