患者由来iPS細胞を用いた筋強直性ジストロフィー骨格筋病態の再現と薬効評価のための定量的な細胞評価系の確立. 京都大学プレスリリース. 2023-01-11. / Reproducing skeletal muscle pathology of myotonic dystrophy using patient-derived iPS cells and establishing a new system to quantitatively evaluate drug efficacy. 京都大学プレスリリース. 2023-01-11. / Myotonic dystrophy type 1 (DM1) is caused by expanded CTG repeats (CTGexp) in...
Published in Journal of ethnopharmacology
Anadenanthera colubrina (Vell.) Brenan is an endemic tree to South America and different parts of it are used by the population for the treatment of various diseases, as well as in indigenous rituals. This species has high pharmacological potential but may present toxic potential due to the presence of psychotropic compounds. To review published st...
Published in Naunyn-Schmiedeberg's archives of pharmacology
The purpose of this article is the historical survey of the foundation and development of pharmacology in Tartu (Dorpat), Estonia. Pharmacology was founded in Tartu by Naunyn, Buchheim, and Schmiedeberg. Genealogy and biographies including selected references of pharmacologists and pupils, who acted from the very beginning to today as directors of ...
Published in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Non-human animal studies outline precise mechanisms of central mu-opioid regulation of pain, stress, affiliation and reward processing. In humans, pharmacological blockade with non-selective opioid antagonists such as naloxone and naltrexone is typically used to assess involvement of the mu-opioid system in such processing. However, robust estimate...
Despite the common use of oral group treatment in pig rearing, the magnitude of the factors influencing the homogeneity and stability of antimicrobial drugs in medicated feed and medicated drinking water are largely unknown, as well as the residual concentrations of the drugs after the end of the treatment.
This study prese...
This study documented indigenous knowledge and use of medicinal plants among the Kuria communities in Mara Region, Tanzania. Ethnobotanical data were collected in collaboration with 20 traditional healers (THs), by jungle-walk-and-identify, field guides and observation, semi-structured interviews, focus group discussions and scientific identificati...
Recently there has been increase in patronage of herbal medicine due to economic constrain particularly among low income earners in the developing countries such as Nigeria. Gynura procumbens, (Molucan spinach) is widely used in traditional medicine for treatment of wide ailments such as fever, malaria, anti-glycaemic, rheumatism, hypertension, dia...
Published in Naunyn-Schmiedeberg's archives of pharmacology
The Institute of Pharmacology of the University of Strasbourg played an eminent role in the development and international spread of pharmacology between 1872 and 1918. In this article, genealogy and biographies of key players are documented. Unfortunately, lack of data did not permit the complete biographical description of all scientists. Oswald S...
Published in Cardiovascular diabetology
Results of cardiovascular outcome trials enabled a shift from "treat-to-target" to "treat-to-benefit" paradigm in the management of type 2 diabetes (T2D). However, studies validating such approach are limited. Here, we examined whether treatment according to international recommendations for the pharmacological management of T2D had an impact on lo...
Published in Chinese medicine
Taxillus chinensis (DC.) Danser (T. chinensis), known as "Sangjisheng" in Chinese, is a member of the family Loranthaceae, with the traditional functions of "dispelling wind dampness, strengthening bones and muscles, and preventing miscarriage". Since Eastern Han dynasty, it has been used for the treatment of rheumatoid arthritis, arthralgia, threa...
