Desale, Smita Eknath Chinnathambi, Subashchandrabose
Published in
Cell Communication and Signaling : CCS
Alzheimer’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells. The pathological protein in neurodegenerative diseases, Tau and amyloid-β contribute to the disrupted microglial signaling pathways, actin cytoskeleton, and...
Corbett, Yolanda Parapini, Silvia Perego, Federica Messina, Valeria Delbue, Serena Misiano, Paola Falchi, Mario Silvestrini, Francesco Taramelli, Donatella Basilico, Nicoletta
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Published in
Malaria Journal
BackgroundThe innate immune response against various life cycle stages of the malaria parasite plays an important role in protection against the disease and regulation of its severity. Phagocytosis of asexual erythrocytic stages is well documented, but little and contrasting results are available about phagocytic clearance of sexual stages, the gam...
Desale, Smita Eknath Chinnathambi, Subashchandrabose
Published in
Molecular Biomedicine
Alzheimer’s disease (AD) is known by characteristic features, extracellular burden of amyloid-β and intracellular neuronal Tau. Microglia, the innate immune cell of the brain has the ability to clear the burden of accumulated proteins via phagocytosis. But the excessive proinflammatory cytokine production, altered cellular signaling and actin remod...
Zhong, Hanhui Lin, Haitao Pang, Qiongni Zhuang, Jinling Liu, Xiaolei Li, Xiaolian Liu, Jinghua Tang, Jing
Published in
Inflammation Research
Objective Intracellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein belonging to the immunoglobulin superfamily, plays a critical role in mediating cell–cell interaction and outside-in cell signaling during the immune response. ICAM-1 is expressed on the cell surface of several cell types including endothelial cells, epithelial cells...
Cai, Xiaoying Li, Ying Zheng, Xiaoyang Hu, Rong Li, Yingyuan Xiao, Liangcan Wang, Zhongxing
Published in
Journal of Neuroinflammation
BackgroundMicroglia are highly motile phagocytic cells in the healthy brain with surveillance and clearance functions. Although microglia have been shown to engulf cellular debris following brain insult, less is known about their phagocytic function in the absence of injury. Propofol can inhibit microglial activity, including phagocytosis. Milk fat...
Kohno, Keizo Koya-Miyata, Satomi Harashima, Akira Tsukuda, Takahiko Katakami, Masataka Ariyasu, Toshio Ushio, Shimpei Iwaki, Kanso
Published in
Journal of Inflammation
BackgroundNK-4 has been used to promote wound healing since the early-1950s; however, the mechanism of action of NK-4 is unknown. In this study, we examined whether NK-4 exerts a regulatory effect on macrophages, which play multiple roles during wound healing from the initial inflammatory phase until the tissue regeneration phase.ResultsNK-4 treatm...
Pons, Vincent Lévesque, Pascal Plante, Marie-Michèle Rivest, Serge
Published in
Alzheimer's Research & Therapy
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the world. Microglia are the innate immune cells of CNS; their proliferation, activation, and survival in pathologic and healthy brain have previously been shown to be highly dependent on CSF1R.MethodsHere, we investigate the impac...
Rivera-Millot, Alex Slupek, Stéphanie Chatagnon, Jonathan Roy, Gauthier Saliou, Jean-Michel Billon, Gabriel Alaimo, Véronique Hot, David Salomé-Desnoulez, Sophie Locht, Camille
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International audience
Titon, Stefanny Christie Monteiro Titon Junior, Braz Assis, Vania Regina Vasconcelos-Teixeira, Ronyelle Garcia Neto, Patrício Getúlio Lima, Alan Siqueira Ferreira, Letícia de França Fernandes, Pedro A Gomes, Fernando Ribeiro Markus, Regina P
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Published in
General and comparative endocrinology
Almost all physiological processes within the organism, including immune parameters and hormones, follow a circadian rhythm. These daily fluctuations are often observed in free-living organisms; however, little is known regarding hormonal and immune daily variations in anurans, particularly under laboratory conditions. This study aimed to investiga...
Jiang, Rui Lu, Xin-Jiang Lu, Jian-Fei Chen, Jiong
Published in
Developmental and comparative immunology
Urocortin (UCN) is a hormone in the hypothalamic-pituitary-adrenal axis that is expressed in various immune cells. However, the function of teleost UCN in the immune system remains unclear. In this study, we cloned the cDNA sequence of UCN from ayu Plecoglossus altivelis (PaUCN). Sequence and phylogenetic tree analyses showed that PaUCN clustered w...
