Guan, Meng-Qi Yao, Lei Zhen, Yu Song, Yang Cui, Yan Li, Shan-Shan
Published in
Microbial pathogenesis
Melanin is an important virulence factor for Sporothrix globosa, the causative agent of sporotrichosis, a subcutaneous mycosis that occurs worldwide. Although previous research suggests that melanin is involved in the pathogenesis of sporotrichosis, little is known about its influence on the macrophages that represent the frontline components of in...
Chen, Jingyin Koduri, Sravanthi Dai, Shuhui Toyota, Yasunori Hua, Ya Chaudhary, Neeraj Pandey, Aditya S Keep, Richard F Xi, Guohua
Published in
Translational stroke research
Intracerebral hemorrhage (ICH) is a stroke subtype with high mortality and severe morbidity. Hemorrhages frequently develop within the white matter, but whether white matter fibers within the hematoma survive after ICH has not been well studied. The current study examines whether white matter fibers persist in the hematoma after ICH, fibers that mi...
Tahk, Siret Vick, Binje Hiller, Björn Schmitt, Saskia Marcinek, Anetta Perini, Enrico D. Leutbecher, Alexandra Augsberger, Christian Reischer, Anna Tast, Benjamin
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Published in
Journal of Hematology & Oncology
Background Acute myeloid leukaemia (AML) stem cells (LSCs) cause disease relapse. The CD47 “don’t eat me signal” is upregulated on LSCs and contributes to immune evasion by inhibiting phagocytosis through interacting with myeloid-specific signal regulatory protein alpha (SIRPα). Activation of macrophages by blocking CD47 has been successful, but th...
Yamazaki, Manabu Maruyama, Satoshi Abé, Tatsuya Sumita, Yoshimasa Katsumi, Yuji Nikkuni, Yutaka Hayashi, Takafumi Tanuma, Jun-ichi
Published in
Journal of Medical Case Reports
Background Spindle cell squamous cell carcinoma is an uncommon variant of squamous cell carcinoma; its diagnosis is sometimes challenging because it histopathologically resembles neoplastic or reactive spindle cell lesions of mesenchymal origins. Here, we report a rare case of spindle cell squamous cell carcinoma exhibiting prominent neutrophil pha...
Habar, Tommy Rubiyanto Islam, Andi Asadul Hatta, Mochammad Warsinggih, Mahmudi, Ahmad Massi, Muhammad Nasrum Bukhari, Agussalim Kusmayadi, Dikki Drajat Diposarosa, Rizki Mappiwali, Asrul
...
Published in
Annals of Medicine and Surgery
• Transfer factors increase the activity of natural killer (NK) cells. • Transfer factors enhanced the phagocytic activity of macrophages in a rat model of peritonitis. • Transfer factors have a role as an immunomodulatory treatment in peritonitis cases.
Hunter, Mandana Spiller, Krista J. Dominique, Myrna A. Xu, Hong Hunter, Francis W. Fang, Terry C. Canter, Rebecca G. Roberts, Christopher J. Ransohoff, Richard M. Trojanowski, John Q.
...
Published in
Acta Neuropathologica Communications
The microglial reaction is a hallmark of neurodegenerative conditions, and elements thereof may exert differential effects on disease progression, either worsening or ameliorating severity. In amyotrophic lateral sclerosis (ALS), a syndrome characterized by cytoplasmic aggregation of TDP-43 protein and atrophy of motor neurons in the cortex and spi...
Enlow, William Bordeleau, Maude Piret, Jocelyne Ibáñez, Fernando González Uyar, Olus Venable, Marie-Christine Goyette, Nathalie Carbonneau, Julie Tremblay, Marie-Eve Boivin, Guy
...
Published in
Journal of Neuroinflammation
Background Zika virus (ZIKV) has been associated with several neurological complications in adult patients. Methods We used a mouse model deficient in TRIF and IPS-1 adaptor proteins, which are involved in type I interferon production, to study the role of microglia during brain infection by ZIKV. Young adult mice were infected intravenously with t...
Boddy, Kirsten C. Zhu, Hongxian D’Costa, Vanessa M. Xu, Caishuang Beyrakhova, Ksenia Cygler, Miroslaw Grinstein, Sergio Coyaud, Etienne Laurent, Estelle M. N. St-Germain, Jonathan
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Published in
Nature Communications
Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal of Rab10 and recruitment of dynamin-2 to drive plasma membrane scission.
Chua, Caroline Lin Lin Ng, Ida May Jen Yap, Bryan Ju Min Teo, Andrew
Published in
Malaria Journal
There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation of a regulated inflammatory response, is beneficial for par...
Wang, Mao Gauthier, Alex G. Kennedy, Thomas P. Wang, Haichao Velagapudi, Uday Kiran Talele, Tanaji T. Lin, Mosi Wu, Jiaqi Daley, LeeAnne Yang, Xiaojing
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Published in
Molecular Medicine
BackgroundHigh mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the clearance of invading pulmonary pathogens and dying neutrophils in the injured lungs of cystic fibrosis (CF) and acute respiratory distre...
