Crehan, Helen Liu, Bin Kleinschmidt, Martin Rahfeld, Jens-Ulrich Le, Kevin X. Caldarone, Barbara J. Frost, Jeffrey L. Hettmann, Thore Hutter-Paier, Birgit O’Nuallain, Brian
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Published in
Alzheimer's Research & Therapy
BackgroundPyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive emerging treatment strategy for AD. We address the question of how the effector function of an anti-pGlu-3 Aβ anti...
Khorooshi, Reza Marczynska, Joanna Dieu, Ruthe Storgaard Wais, Vian Hansen, Christian Rønn Kavan, Stephanie Thomassen, Mads Burton, Mark Kruse, Torben Webster, Gill A.
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Published in
Acta Neuropathologica Communications
There is great interest in understanding how the central nervous system (CNS) communicates with the immune system for recruitment of protective responses. Infiltrating phagocytic monocytes and granulocytes are implicated in neuroinflammation in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). To investigate h...
Elberg, Gerard Liraz-Zaltsman, Sigal Reichert, Fanny Matozaki, Takashi Tal, Michael Rotshenker, Shlomo
Published in
Journal of Neuroinflammation
BackgroundRecovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physical impact severed axons, determined by the type of trauma, followed by successfully growing throughout the Wallerian degenerating ne...
Calle, Priscila Muñoz, Angeles Sola, Anna Hotter, Georgina
Published in
Lipids in Health and Disease
BackgroundMacrophage are specialized cells that contributes to the removal of detrimental contents via phagocytosis. Lipid accumulation in macrophages, whether from phagocytosis of dying cells or from circulating oxidized low-density lipoproteins, alters macrophage biology and functionality. It is known that carnitine palmitoyl transferase 1-a (CPT...
Rivera-Escalera, Fátima Pinney, Jonathan J. Owlett, Laura Ahmed, Hoda Thakar, Juilee Olschowka, John A. Elliott, Michael R. O’Banion, M. Kerry
Published in
Journal of Neuroinflammation
BackgroundNeuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus of APP/PS1 mice decreases amyloid plaque burden independent o...
Lian, D W Xu, Y F Deng, Q H Lin, X M Huang, B Xian, S X Huang, P
Published in
Phytomedicine : international journal of phytotherapy and phytopharmacology
Helicobacter pylori infects almost half of the world population and is listed as a type I carcinoma factor since 1994. Pogostemon cablin (Blanco) Benth. (Labiatae) has been used to treat gastro-intestinal diseases for thousands of years in many east Asian countries, and the key ingredient, patchouli alcohol (PA), has been observed to exert anti-H. ...
Jiang, Pingping Yang, Wentao Jin, Yubei Huang, Haibin Shi, Chunwei Jiang, Yanlong Wang, Jianzhong Kang, Yuanhuan Wang, Chunfeng Yang, Guilian
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Published in
Microbial pathogenesis
Lactobacillus reuteri, a typical intestinal symbiotic bacterium, plays an important role in maintaining intestinal flora stability and host health. However, the effect of Lactobacillus reuteri on peritoneal macrophages has not been thoroughly studied. Our study indicated that Lactobacillus reuteri could activate macrophages and that macrophages tre...
Thalla, Maharshi Kant, Kamal Sharma, Dalchand Rawat, Ravi Banerjee, Subham
Published in
Journal of biomolecular structure & dynamics
Macrophage mannose receptor (MMR) is a C-type lectin that regulates the phagocytosis and phagocytosis-lysosome (P-L) fusion in tuberculosis. Mannose-capped lipoarabinomannan (ManLAM), a lipoglycan present at the surface of Mycobacterium tuberculosis (MT), is an important factor in phagocyte attachment and internalization that is specific for MMR. B...
Xia, Bin Zhang, Jing Zhao, Xinguo Feng, Juan Teng, Yao Chen, Bijuan Sun, Xuemei Zhu, Lin Sun, Xiaojie Qu, Keming
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Published in
Environmental pollution (Barking, Essex : 1987)
Microplastics are a growing problem in marine environments due to their ubiquitous occurrence and affinity for chemical pollutants. However, the influence of microplastics on the uptake, depuration and toxicity of decabromodiphenyl ether (BDE-209) in marine organisms is unclear. We exposed the marine scallop Chlamys farreri to polystyrene microplas...
Pedicone, C Fernandes, S Dungan, O M Dormann, S M Viernes, D R Adhikari, A A Choi, L B De Jong, E P Chisholm, J D Kerr, W G
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Published in
Journal of cell science
We show here that both SHIP1 and its paralog SHIP2 are expressed at the protein level in microglia. To examine whether targeting of SHIP paralogs might influence microglial physiology and function we tested the capacity of SHIP1-selective, SHIP2-selective and pan-SHIP1/2 inhibitors for their ability to impact microglia proliferation, lysosomal comp...
