Liu, Zhi-Hao Bai, Yu-Di Yu, Zhong-Yuan Li, Hui-Yun Liu, Jie Tan, Cheng-Rong Zeng, Gui-Hua Tu, Yun-Feng Sun, Pu-Yang Jia, Yu-Juan
...
Published in
Neuroscience bulletin
Deficiencies in the clearance of peripheral amyloid β (Aβ) play a crucial role in the progression of Alzheimer's disease (AD). Previous studies have shown that the ability of blood monocytes to phagocytose Aβ is decreased in AD. However, the exact mechanism of Aβ clearance dysfunction in AD monocytes remains unclear. In the present study, we found ...
Khalaji, Amirreza Yancheshmeh, Fatereh Farham, Fatemeh Khorram, Arya Sheshbolouki, Shiva Zokaei, Maryam Vatankhah, Fatemeh Soleymani Goloujeh, Mehdi
Cancer stands as one of the prominent global causes of death, with its incidence burden continuously increasing, leading to a substantial rise in mortality rates. Cancer treatment has seen the development of various strategies, each carrying its drawbacks that can negatively impact the quality of life for cancer patients. The challenge remains sign...
Perron, Clarisse Carme, Pascal Rosell, Arnau Llobet Minnaert, Eva Ruiz-Demoulin, Salomé Szczkowski, Héloïse Neukomm, Lukas Jakob Dura, Jean‐maurice Boulanger, Ana
During animal development, neurons often form exuberant or inappropriate axons and dendrites at early stages, followed by the refinement of neuronal circuits at late stages. Neural circuit refinement leads to the production of neuronal debris in the form of neuronal cell corpses, fragmented axons and dendrites, and pruned synapses requiring disposa...
Dundee, Jacob M Puigdellívol, Mar Butler, Richard Brown, Guy C
During brain development, excess synapses are pruned (i.e., removed), in part by microglial phagocytosis, and dysregulated synaptic pruning can lead to behavioral deficits. The P2Y6 receptor (P2Y6R) is known to regulate microglial phagocytosis of neurons, and to regulate microglial phagocytosis of synapses in cell culture and in vivo during aging. ...
Lefebvre, Marion Razakandrainibe, Romy Schapman, Damien François, Arnaud Genty, Damien Galas, Ludovic Villena, Isabelle Favennec, Loic Costa, Damien
Published in
Parasite
Free-Living Amebae (FLA) and Cryptosporidium oocysts occasionally share the same environment. From 2004 to 2016, Cryptosporidium was responsible for 60% of 905 worldwide waterborne outbreaks caused by protozoan parasites. The aim of this study was to evaluate interactions between C. parvum oocysts and two common FLAs (Acanthamoeba castellanii and V...
Desanti, Guillaume E Fejer, Gyorgy Christophe, Olivier D Onyishi, Chinaemerem U Wilkinson, Alex L Lara-Reyna, Samuel Frickel, Eva-Maria Bryant, Clare E Mukhopadhyay, Subhankar Gordon, Siamon
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Funder: Wellcome Trust / The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised and phagocytosed by macrophages. Here we investigate the role of TLR4 in the non-opsonic phagoc...
Quick, Joseph D Silva, Cristian Wong, Jia Hui Lim, Kah Leong Reynolds, Richard Barron, Anna M Zeng, Jialiu Lo, Chih Hung
Published in
Journal of neuroinflammation
Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Being a professional phagocyte, microglia participate in phagocytic and autophagic clearance of cellular waste ...
Bukeyeva, Tamara A Murzageldinova, Sabina G Serikbay, Aray A Krasnoshtanov, Arkadiy V Korotetskiy, Ilya S
Published in
Data in brief
The aim of this study was to evaluate phagocytic and oxidative activities of monocytes and granulocytes during combined therapy of mice infected by drug-resistant Staphylococcus aureus SCAID OTT1-2022. The treatment of the infected mice was conducted by using an iodine-containing coordination compound CC-195, antibiotic cefazolin and by a combined ...
Xu, Yajing Moulding, Dale Jin, Wenanlan Beggs, Simon
Published in
Brain, behavior, and immunity
Peripheral injury during the early postnatal period alters the somatosensory system, leading to behavioural hyperalgesia upon re-injury in adulthood. Spinal microglia have been implicated as the cellular mediators of this phenomenon, but the mechanism is unclear. We hypothesised that neonatal injury (1) alters microglial phagocytosis of synapses in...
Wuerch, Emily Urgoiti, Gloria Roldan Yong, V Wee
Published in
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Niacin (vitamin B3) is an essential nutrient that treats pellagra, and prior to the advent of statins, niacin was commonly used to counter dyslipidemia. Recent evidence has posited niacin as a promising therapeutic for several neurological disorders. In this review, we discuss the biochemistry of niacin, including its homeostatic roles in NAD+ supp...
