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Oka, Tatsuya Rios, Eon J Tsai, Mindy Kalesnikoff, Janet Galli, Stephen J
Published in
The Journal of allergy and clinical immunology
Rapid desensitization transiently prevents severe allergic reactions, allowing administration of life-saving therapies in previously sensitized patients. However, the mechanisms underlying successful rapid desensitization are not fully understood. We sought to investigate whether the mast cell (MC) is an important target of rapid desensitization in...
Mukai, Hidehito Kikuchi, Miharu Fukuhara, Shigetomo Kiso, Yoshiaki Munekata, Eisuke
Published in
Biochemical and Biophysical Research Communications
Amphiphilic peptides with positive charges such as substance P (SP) and mastoparan (MP) are known to induce exocytosis in rat peritoneal mast cells. To elucidate whether and how intracellular Ca 2+ signaling is involved in the peptide-induced exocytosis, here we investigated the relationships between an increase in intracellular free Ca 2+ concentr...
Minami, Kumiko Nakasugi, Toru Sun, Han-Dong Hou, Ai-Jun Ihara, Makoto Morimoto, Masanori Komai, Koichiro
Published in
Journal of Natural Medicines
Seven histamine-release inhibitors were isolated from Pistacia weinmannifolia J. Pisson ex. Franch. They were identified as gallic acid, 3-O-galloylquinic acid, methyl gallate, ethyl gallate, penta-O-galloyl-β-d -glucopyranoside, myricetin 3-O-α-l-rhamnopyranoside, and myricetin- 3-O-(3′′-O-galloyl)-α-l-rhamnopyranoside. These compounds suppressed ...
Joly, F. Charveron, M. Ariès, M.F. Bidault, J. Kahhak, L. Beauvais, F. Gall, Y.
Published in
Skin Pharmacology and Physiology
The biological activity of Avène water from two different springs (‘Sainte Odile’ and ‘Val d’Orb’) was studied in vitro on rat peritoneal mast cell activation. A dilution-dependent inhibition of both histamine and prostaglandin D2 antigen-induced release was observed when cells were preincubated with both Avène spring waters. They also inhibited hi...
