Wu, Zhixin Wen, Yinxian Fan, Guanlan He, Hangyuan Zhou, Siqi Chen, Liaobin
Published in
BMC Musculoskeletal Disorders
BackgroundSteroid-induced osteonecrosis of the femoral head (SONFH) is a chronic and crippling bone disease. This study aims to reveal novel diagnostic biomarkers of SONFH.MethodsThe GSE123568 dataset based on peripheral blood samples from 10 healthy individuals and 30 SONFH patients was used for weighted gene co-expression network analysis (WGCNA)...
Cao, Ting Li, NaNa Cai, HuaLin
Published in
Schizophrenia research
Due to the limitations of analytical techniques and the complicity of schizophrenia, nowadays it is still a challenge to diagnose and stratify schizophrenia patients accurately. Many attempts have been made to identify and validate available biomarkers for schizophrenia from CSF and/or peripheral blood in clinical studies with consideration to dise...
Qing, Lili Liu, Linlin Zhou, Li Zhang, Fan Gao, Changqing Hu, Liping Nie, Shengjie
Published in
Psychiatry research
Schizophrenia is a complex disease caused by genetic and environmental factors. Epigenetic regulation mediates gene-environment interactions by modulating gene expression. Abnormal activation of the hypothalamic-pituitary-adrenal (HPA) axis has been widely reported in schizophrenia patients. The DNA methylation levels of critical genes are associat...
Seong, Jin-Hee Song, Yi-Sun Joo, Hyun-Woo Park, In-Hwa Shen, Guang-Yin Shin, Na-Kyoung Lee, A-Hyeon Kwon, Amy M. Lee, Yonggu Kim, Hyuck
...
Published in
Cytotechnology
In previous studies, vascular smooth muscle progenitor cells (vSMPCs) isolated from peripheral blood mononuclear cells (PBMCs) were cultured using medium containing platelet-derived growth factor-BB (PDGF-BB) for 4 weeks. However, this method requires long culture periods of up to 4 weeks and yields low cell counts. Therefore, we proposed the modif...
Zhang, Yiyin Ni, Longgang Li, Qianqian Li, Min Zhu, Jiejie Zhang, Fei Gu, Kangsheng
Published in
Journal of Cancer
Purpose: Heat shock protein 90 (HSP90) is a critical molecular chaperone for protein folding, intracellular disposition and regulation of tumor biological behavior in the extracellular space. HSP90 has received much attention due to its specific effect in gastrointestinal cancer. This clinical study sought to determine whether HSP90 in plasma may s...
Onwuka, Justina Ucheojor Li, Dapeng Liu, Yupeng Huang, Hao Xu, Jing Liu, Ying Zhang, Yuanyuan Zhao, Yashuang
Published in
BMC Cancer
BackgroundDifferential DNA methylation panel derived from peripheral blood could serve as biomarkers of CRC susceptibility. However, most of the previous studies utilized post-diagnostic blood DNA which may be markers of disease rather than susceptibility. In addition, only a few studies have evaluated the predictive potential of differential DNA m...
Nazarullah, Alia Liang, Christine Villarreal, Andrew Higgins, Russell A Mais, Daniel D
Published in
American Journal of Clinical Pathology
Objectives Peripheral blood abnormalities in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been fully elucidated. We report qualitative and quantitative peripheral blood findings in coronavirus disease 2019 (COVID-19) patients and compare them with a control group. Methods We reviewed electronic medical records, complete blo...
Vasanthakumar, Aparna Davis, Justin W. Idler, Kenneth Waring, Jeffrey F. Asque, Elizabeth Riley-Gillis, Bridget Grosskurth, Shaun Srivastava, Gyan Kim, Sungeun Nho, Kwangsik
...
Published in
Clinical Epigenetics
BackgroundAlzheimer’s disease (AD) is a chronic progressive neurodegenerative disease impacting an estimated 44 million adults worldwide. The causal pathology of AD (accumulation of amyloid-beta and tau), precedes hallmark symptoms of dementia by more than a decade, necessitating development of early diagnostic markers of disease onset, particularl...
Wang, Xian Yang, Jiao Qiu, Xianliang Wen, Qing Liu, Min Chen, Qiu
Published in
Medicine
Epidemiology of type 2 diabetes (T2D) is affected by genetic and environmental factors. Deoxyribonucleic acid (DNA) methylation as a kind of epigenetic mechanism has been reported to affect the pathogenesis of T2D. Both global DNA methylation and candidate genes were observed differentially methylated and identified changes. Peripheral blood biomar...
Miyamoto, Kendi Nishino Bonatto, Diego
Published in
Clinical immunology (Orlando, Fla.)
Acute myelogenous leukemia (AML) is an aggressive hematological malignancy associated with high rates of mortality. This incidence is due to the complexity in which the AML cells interact with other healthy human cells. These phenomena create an environment that favors the expansion of leukemic cells, which will affect the patient's prognosis. An i...
