Archives of oral biology
To clarify the role of cellular communication network factor 2/connective tissue growth factor (CCN2/CTGF) in periodontal tissue regeneration by investigating, the proliferative and tubulogenic responses of human endothelial cells obtained from the periodontal ligament to CCN2/CTGF. Endothelial cells were seeded on agar gel medium with or without 5...
The role of the gingiva in the tactile perception of teeth is unclear, and the physiological basis of tooth tactile function needs to be examined at the cortical response level. In the presented study, gingiva from the upper left canine was removed under local anesthesia from five cats. Intrinsic signal optical imaging was used to measure populatio...
The Journal of International Medical Research
Objective The growth factor progranulin (PGRN) is widely expressed and plays important roles in anti-inflammatory signaling and bone regeneration. However, the anti-inflammatory and pro-osteogenic roles of PGRN in periodontitis are seldom studied. We used an in vitro model to investigate whether PGRN can promote osteogenic differentiation of period...
Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie
Nur in der Ibuprofen-Gruppe zeigten sich signifikante Verringerungen der SP-Spiegel an den Tagen 0 und 1 sowie der VAS-Werte zu Studienbeginn.
Clinical oral investigations
The objective of this study was to investigate the optimal range of rotational moment for the mandibular lateral incisor, canine and first premolar to determine tooth movements during orthodontic treatment using hydrostatic stress and logarithmic strain on the periodontal ligament (PDL) as indicators by numerical simulations. Teeth, PDL and alveola...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Periodontitis is the most common chronic inflammatory disease, and a leading cause of tooth loss. Characterized by resorption of alveolar process and destruction of periodontal ligaments, periodontitis can impact not only periodontal tissues but also systemic diseases, such as diabetes, cardiovascular diseases, and respiratory infections. Currently...
Journal of Peking University (Health Sciences)
目的 探索广泛型侵袭性牙周炎(generalized aggressive periodontitis，GAgP)患者牙根形态异常与骨代谢或牙根发育相关基因多态性的关联。 方法 纳入179例GAgP患者，平均(27.23±5.19)岁，男:女=67 : 112，平均存留牙数(26.80±1.84)颗。采用基于基质辅助激光解吸电离飞行时间质谱技术进行9个与骨代谢和牙根发育相关基因的13个单核苷酸多态性位点(single nucleotide polymorphisms，SNPs)的基因型检测。采用全口根尖片评判牙根形态异常，包括锥根、细长根、冠根比例失调、弯曲根、融合根、后牙根形态异常，分析13个SNPs位点不同基因型根形态异常牙的数量及发生率。 结果 GAgP患者根形态异常牙构成比为14.4...
Mesenchymal stem cells (MSCs) are characterized by the potential to differentiate into multiple cell lineages, high proliferation rates, and self-renewal capacity, in addition to the ability to maintain their undifferentiated state. These cells have been identified in physiological oral tissues such as pulp tissue, dental follicle, apical papilla a...
It has been reported that cyclic stretch could induce inflammatory reaction in human periodontal ligament cells (HPDLCs). Though reactive oxygen species (ROS) has been reported to be involved in pathogen-induced periodontal inflammatory reaction, its role in the force-related periodontal diseases has not been well clarified. This study inspected th...
Journal of biomechanics
The periodontal ligament (PDL) is a critical player in the maintenance of tooth health, acting as the primary stabilizer of tooth position. Recent studies have identified two unique regions within the PDL, the 'dense collar' region and the 'furcation' region, which exhibit distinct structural and compositional differences. However, specific functio...