Xu, Xingjian Dikiy, Igor Evans, Matthew R Marcelino, Leandro P Gardner, Kevin H
Published in
Magnetic resonance (Gottingen, Germany)
Recent research on fold-switching metamorphic proteins has revealed some notable exceptions to Anfinsen's hypothesis of protein folding. We have previously described how a single point mutation can enable a well-folded protein domain, one of the two PAS (Per-ARNT-Sim) domains of the human ARNT (aryl hydrocarbon receptor nuclear translocator) protei...
Gleichmann, Tobias Diensthuber, Ralph P Möglich, Andreas
Published in
The Journal of biological chemistry
Modular signal receptors empower organisms to process environmental stimuli into adequate physiological responses. At the molecular level, a sensor module receives signals and processes the inherent information into changes of biological activity of an effector module. To better understand the molecular bases underpinning these processes, we analyz...
Ohno, Marumi Ikenaka, Yoshinori Ishizuka, Mayumi
Published in
Biochemical and Biophysical Research Communications
Aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) are well-conserved transcription factors among species. However, there are a very limited number of reports on the physiological function of AHR, particularly on the regulation of AHR by endogenous compounds. We hence investigated the effects of all-trans retinoic acid (atRA) on cy...
Ding, X. Zhang, Q.-Y.
Published in
Comprehensive Toxicology
The expression and activity of enzymes associated with biotransformation are controlled by a wide range of mechanisms. The amount of the enzyme available in a cell can be regulated either at the stage of transcription or at various post-transcriptional steps. This chapter provides a summary of various mechanisms identified thus far, including those...
Evans, Matthew R Card, Paul B Gardner, Kevin H
Published in
Proceedings of the National Academy of Sciences of the United States of America
The aryl hydrocarbon receptor nuclear translocator (ARNT) is a basic helix-loop-helix Period/ARNT/Single-minded (bHLH-PAS) protein that controls various biological pathways as part of dimeric transcriptional regulator complexes with other bHLH-PAS proteins. The two PAS domains within ARNT, PAS-A and PAS-B, are essential for the formation of these c...
Mitchell, Kristen A. Elferink, Cornelis J.
Published in
Biochemical Pharmacology
The aryl hydrocarbon receptor (AhR) was implicated as a mediator of xenobiotic toxicity over three decades ago. Although a complete picture continues to elude us, investigations by many laboratories during the ensuing period have revealed much about AhR biology in normal physiological processes, as well as the toxicities induced by the dioxins and ...
Haarmann-Stemmann, Thomas Bothe, Hanno Abel, Josef
Published in
Biochemical Pharmacology
2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is a widespread environmental pollutant, which causes a variety of severe health effects, e.g. immunosuppression, hepatotoxicity, and carcinogenesis. The main mediator of TCDD toxicity is the arylhydrocarbon receptor (AhR), which, upon activation, translocates into the nucleus and enforces gene expression...
