Bernal, Susana Lopez-Sanz, Laura Jimenez-Castilla, Luna Prieto, Ignacio Melgar, Ana La Manna, Sara Martin-Ventura, Jose Luis Blanco-Colio, Luis Miguel Egido, Jesus Gomez-Guerrero, Carmen
...
Published in
British journal of pharmacology
Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress, and proteolytic activity in the aortic wall. Targeting Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is a promising strategy for chronic inflammatory diseases. We investigated the vasculoprotective ...
Alagumuthu, Manikandan Rajpoot, Sajjan Baig, Mirza S.
Published in
Cellular and Molecular Bioengineering
Purpose SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is a critical factor in the COVID-19 pathogenesis via interactions with the host cell angiotensin-con...
Robson, B.
Published in
Computers in Biology and Medicine
• This paper “drills down” into the studies of the author's previous COVID-19 paper. • Designing vaccine and drugs must seek to avoid escape mutations. • Subsequence KRSFIEDLLFNKV seems recognizable across many coronaviruses. • The ACE2 binding domain is a target, but shows variation. • A steroid dehydrogenase is argued to remain an interesting mod...
Robson, B.
Published in
Computers in Biology and Medicine
• Bioinformatics studies are carried out on the COVID-19 virus. • A sequence motif KRSFIEDLLFNKV is of particular interest. • Based on the above, synthetic peptides are designed. • Preliminary considerations are also given to non-peptide organic molecules.
Ghadam, Mona Sardari, Soroush Shokrgozar, Mohammad Ali Mahdavi, Mahdiyeh Sadat
Published in
Avicenna journal of medical biotechnology
One of the important therapeutic approaches in cancer field is development of compounds which can block the initial tumor growth and the progression of tumor metastasis with no side effects. Thus, the recent study was carried out to design anti-VEGFR2-peptidomimetics as the most significant factor of angiogenesis process- and evaluate their biologi...
Nguyen, Ha Thanh Guegan, Jean-Philippe Best, Daniel Van De Weghe, Pierre Levoin, Nicolas Legembre, Patrick Jean, Mickael
Proceeding our effort to study protein-protein interaction between the death receptor CD95 and phospholipase PLCγ1, we present in the current work chameleon-like traits of peptidomimetic inhibitors. Minute analysis of the interaction suggests that most of the binding energy relies on van der Waals contacts rather than more specific features, such a...
Mott, Helen R Owen, Darerca
Published in
Seminars in cancer biology
Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using peptidomimetics were successful in cell culture but failed spectacularly in clinical trials, making industry wary of targeting this crit...
McAnany, John D Miller, Benjamin L
Published in
Methods in enzymology
The ever-growing number of RNA species that are recognized as having a role in human disease is driving a demand for novel molecular probes and therapeutics. Producing sequence-selective RNA-binding molecules remains a substantial challenge, however. One approach that has been successful in producing molecules with high affinity and specificity for...
Ferrati, Giovanni Bion, Georgi Harris, Andrew J Greenfield, Susan
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Despite the many attempts to understand the aetiology of Alzheimer's disease, the basic mechanisms accounting for the progressive cycle of neuronal loss are still unknown. Previous work has suggested that the pivotal molecule mediating neurodegeneration could be an independently acting peptide cleaved from acetylcholinesterase. This previously unid...
Chen, He Yang, Qian Ding, Yuan Vasylieva, Natalia Bever, Candace S. Hua, Xiude Wang, Minghua Hammock, Bruce D.
Published in
Analytical and Bioanalytical Chemistry
Phage-displayed peptides have been proven to be powerful reagents for competitive and noncompetitive immunoassays. However, they are unconventional reagents, which greatly limit their analytical commercial applications and require additional reagents for detection. In this work, the peptides that specifically bind with anti-benzothiostrobin monoclo...
