Freisem, Dennis; Rodriguez-Alfonso, Armando A.; Lawrenz, Jan; Zhou, Zhixuan; Monecke, Thomas; Preising, Nico; Endres, Sascha; Wiese, Sebastian; Ständker, Ludger; Kuan, Seah-Ling;
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Autophagy is an evolutionarily ancient catabolic pathway and has recently emerged as an integral part of the innate immune system. While the core machinery of autophagy is well defined, the physiological regulation of autophagy is less understood. Here, we identify a C-terminal fragment of human hemoglobin A (HBA1, amino acids 111-132) in human bon...
Zoltowska, Katarzyna Das, Utpal Lismont, Sam Enzlein, Thomas Maesako, Masato Houser, Mei Franco, Maria Özcan, Burcu Gomes Moreira, Diana Karachentsev, Dmitry
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Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimers disease (AD). However, molecular cascades underlying their toxicity are poorly defined. Here, we explored a novel hypothesis for Aβ42 toxicity that arises from its proven affinity for γ-secretases. We hypothesized that the reported increases in Aβ42, particularly i...
Galasko, Douglas Farlow, Martin Lucey, Brendan Honig, Lawrence Elbert, Donald Bateman, Randall Momper, Jeremiah Thomas, Ronald Rissman, Robert Pa, Judy
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BACKGROUND: Amyloid beta protein (Aβ) is a treatment target in Alzheimers Disease (AD). Lowering production of its parent protein, APP, has benefits in preclinical models. Posiphen, an orally administered small molecule, binds to an iron-responsive element in APP mRNA and decreases translation of APP and Aβ. To augment human data for Posiphen, we e...
Naghavi, Morteza Reeves, Anthony Budoff, Matthew Li, Dong Atlas, Kyle Zhang, Chenyu Atlas, Thomas Roy, Sion K Henschke, Claudia I Wong, Nathan D
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IntroductionCoronary artery calcium (CAC) scans contain useful information beyond the Agatston CAC score that is not currently reported. We recently reported that artificial intelligence (AI)-enabled cardiac chambers volumetry in CAC scans (AI-CAC™) predicted incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA). In this ...
Bolsewig, Katharina; van Unnik, Annemartijn A.J.M.; Blujdea, Elena R.; Gonzalez, Maria C.; Ashton, Nicholas J.; Aarsland, Dag; Zetterberg, Henrik; Padovani, Alessandro; Bonanni, Laura; Mollenhauer, Brit;
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BACKGROUND AND OBJECTIVES: Plasma β-amyloid-1-42/1-40 (Aβ42/40), phosphorylated-tau (P-tau), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) have been widely examined in Alzheimer disease (AD), but little is known about their reflection of copathologies, clinical importance, and predictive value in dementia with Lewy bodies (D...
Chen, Wei Kim, Sharon Lee, Alicia Kim, Yun-Jeong Chang, Chungyu Ton-That, Hung Kim, Reuben Kim, Sangjae Park, No-Hee
GV1001, an anticancer vaccine, exhibits other biological functions, including anti-inflammatory and antioxidant activity. It also suppresses the development of ligature-induced periodontitis in mice. Porphyromonas gingivalis (Pg), a major human oral bacterium implicated in the development of periodontitis, is associated with various systemic disord...
Li, Meihan Castro Lingl, Sascha Yang, Jerry
COVID-19 infection is associated with a variety of vascular occlusive morbidities. However, a comprehensive understanding of how this virus can induce vascular complications remains lacking. Here, we show that a peptide fragment of SARS-CoV-2 spike protein, S192 (sequence 192-211), is capable of forming amyloid-like aggregates that can induce agglu...
Odorcic, Ivica; 117947; Hamed, Mohamed Belal; Lismont, Sam; Chavez-Gutierrez, Lucia; 50182; Efremov, Rouslan G.;
Deposition of amyloid-β (Aβ) peptides in the brain is a hallmark of Alzheimer's disease. Aβs are generated through sequential proteolysis of the amyloid precursor protein by the γ-secretase complexes (GSECs). Aβ peptide length, modulated by the Presenilin (PSEN) and APH-1 subunits of GSEC, is critical for Alzheimer's pathogenesis. Despite high rele...
Morris, Owen M Toprakcioglu, Zenon Röntgen, Alexander Cali, Mariana Knowles, Tuomas PJ Vendruscolo, Michele
The deposition of the amyloid-β (Aβ) peptide into amyloid fibrils is a hallmark of Alzheimer's disease. Recently, it has been reported that some proteins can aggregate and form amyloids through an intermediate pathway involving a liquid-like condensed phase. These observations prompted us to investigate the phase space of Aβ. We thus explored the a...
Meyer, Matthew Kirmess, Kristopher Eastwood, Stephanie Wente-Roth, Traci Irvin, Faith Holubasch, Mary Venkatesh, Venky Fogelman, Ilana Monane, Mark Hanna, Lucy
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BACKGROUND: With the availability of disease-modifying therapies for Alzheimers disease (AD), it is important for clinicians to have tests to aid in AD diagnosis, especially when the presence of amyloid pathology is a criterion for receiving treatment. METHODS: High-throughput, mass spectrometry-based assays were used to measure %p-tau217 and amylo...