Lindsey, Hannah M Lalani, Sanam J Mietchen, Jonathan Gale, Shawn D Wilde, Elisabeth A Faber, Jessica MacLeod, Marianne C Hunter, Jill V Chu, Zili D Aitken, Mary E
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Published in
Brain imaging and behavior
Mediation analysis was used to investigate the role of white matter integrity in the relationship between injury severity and verbal memory performance in participants with chronic pediatric traumatic brain injury (TBI). DTI tractography was used to measure fractional anisotropy (FA) within the corpus callosum, fornix, cingulum bundles, perforant p...
Ware, Ashley L. Shukla, Ayushi Goodrich-Hunsaker, Naomi J. Lebel, Catherine Wilde, Elisabeth A. Abildskov, Tracy J. Bigler, Erin D. Cohen, Daniel M. Mihalov, Leslie K. Bacevice, Ann
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Published in
NeuroImage : Clinical
Introduction Mild traumatic brain injury (TBI) is a global public health concern that affects millions of children annually. Mild TBI tends to result in subtle and diffuse alterations in brain tissue, which challenges accurate clinical detection and prognostication. Diffusion tensor imaging (DTI) holds promise as a diagnostic and prognostic tool, b...
Fraunberger, Erik Esser, Michael J.
Published in
Brain Sciences
Compared to traumatic brain injury (TBI) in the adult population, pediatric TBI has received less research attention, despite its potential long-term impact on the lives of many children around the world. After numerous clinical trials and preclinical research studies examining various secondary mechanisms of injury, no definitive treatment has bee...
Narad, Megan E Treble-Barna, Amery Zang, Huaiyu Zhang, Nanhua Smith, Julia Yeates, Keith O Taylor, H Gerry Stancin, Terry Wade, Shari L
Published in
Developmental neurorehabilitation
Purpose: Examine the impact of traumatic brain injury (TBI) on parenting behavior over time. Method: Included 206 children (3-7 years old) with moderate to severe TBI or orthopedic injury, using a prospective longitudinal cohort study design. Assessments completed at baseline, 6-months, 12-months, 18-months, 3.5 years, and 6.8 years after injury. D...
Hajiaghamemar, Marzieh Seidi, Morteza Oeur, R. Anna Margulies, Susan S.
Published in
Experimental neurology
Traumatic brain injury is a leading cause of cognitive and behavioral deficits in children in the US each year. There is an increasing interest in both clinical and pre-clinical studies to discover biomarkers to accurately diagnose traumatic brain injury (TBI), predict its outcomes, and monitor its progression especially in the developing brain. In...
Vander Linden, Catharine Verhelst, Helena Genbrugge, Eva Deschepper, Ellen Caeyenberghs, Karen Vingerhoets, Guy Deblaere, Karel
Published in
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Traumatic brain injury (TBI) is a heterogeneous disorder in which diffuse axonal injury (DAI) is an important component contributing to executive dysfunction. During adolescence, developing brain networks are especially vulnerable to acceleration-deceleration forces. We aimed to examine the correlation between DAI (number and localization) and exec...
Hajiaghamemar, Marzieh Lan, Ingrid S. Christian, Cindy W. Coats, Brittany Margulies, Susan S.
Published in
International Journal of Legal Medicine
Skull fractures are common injuries in young children, typically caused by accidental falls and child abuse. The paucity of detailed biomechanical data from real-world trauma in children has hampered development of biomechanical thresholds for skull fracture in infants. The objectives of this study were to identify biomechanical metrics to predict ...
Catharine, Vander Linden Helena, Verhelst Ellen, Deschepper Guy, Vingerhoets Karel, Deblaere Karen, Caeyenberghs
Published in
NeuroImage. Clinical
Sustaining a traumatic brain injury (TBI) during adolescence has a profound effect on brain development and can result in persistent executive functioning deficits in daily life. Cognitive recovery from pediatric-TBI relies on the potential of neuroplasticity, which can be fostered by restorative training-programs. However the structural mechanisms...
Sarnaik, Ajit Ferguson, Nikki Miller O’Meara, AM Iqbal Agrawal, Shruti Deep, Akash Buttram, Sandra Bell, Michael J. Wisniewski, Stephen R. Luther, James F. Hartman, Adam L.
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Published in
Neurocritical Care
BackgroundAlthough small series have suggested that younger age is associated with less favorable outcome after severe traumatic brain injury (TBI), confounders and biases have limited our understanding of this relationship. We hypothesized that there would be an association between age and mortality in children within an ongoing observational, coh...
Ajdari, Ali Boyle, Linda Ng Kannan, Nithya Wang, Jin Rivara, Frederick P. Vavilala, Monica S.
Published in
Journal for healthcare quality : official publication of the National Association for Healthcare Quality
The treatment of patients in the emergency department (ED) with severe pediatric traumatic brain injury (TBI) is challenging, and treatment process strategies that facilitate good outcomes are not well documented. The overall objective of this study is to identify factors that can impact the care process associated with pediatric TBI. This objectiv...
