Siriwannakij, Nitprapa Heimbach, Tycho Serajuddin, Abu T M
Published in
Journal of pharmaceutical sciences
In this study, the lack of complete drug release from amorphous solid dispersions (ASDs), as observed in most published reports, was investigated. ASDs with 20% ritonavir were prepared by HME using polyvinylpyrrolidone vinyl acetate (PVPVA) alone and in combination with 10% poloxamer 407 or Span 20 as carriers. It was established by the film castin...
Rohner, Nathan A Purdue, Linda N von Recum, Horst A
Published in
Journal of pharmaceutical sciences
Drug delivery to specific arms of the immune system can be technically challenging to provide prolonged drug release while limiting off-target toxicity given the limitations of current drug delivery systems. In this work, we test the design of a cyclodextrin (CD) polymer platform to extend immunomodulatory drug delivery via affinity interactions fo...
Le Guellec, S Ehrmann, S Vecellio, L
Published in
Advanced drug delivery reviews
In vitro - in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally inhaled drug based on in vitro drug measurements. In vitro measurements include physical particle characterization and, more recently, deposition studies using anatomical models. Currently, there is a lack of IVIVC for deposition measurements in anato...
Liu, Hengsan Wang, Miaohui Xu, Yifei Ge, Xueyuan Li, Jing Liang, Jinming
Published in
International Journal of Materials Research
The oxidation behavior of two kinds of H13 steel powders were studied at different temperatures in air. Both oxidation kinetics and oxidation products were investigated, and the effect of powder particle size distribution on the powder oxidation was also evaluated. In addition, elemental and microstructural analyses were also conducted to character...
Zhang, Yuemei Puolanne, Eero Ertbjerg, Per
Published in
Food chemistry
This study aims at providing new insight on protein denaturation in freezing-thawing. Freezing-thawing minced pork reduced water-holding of myofibrils and increased surface hydrophobicity. One additional freezing-thawing cycle at slow freezing rate caused appearance of a 160 kDa myosin-4 fragment in SDS-PAGE, further decreased water-holding of myof...
Gui, Hui Xu, Jinpeng Zhang, Yudong Li, Yang
Published in
Arabian Journal of Geosciences
Fault core can act as a fine groundwater seepage conduit or barrier in coal mines in China. The material properties including the granularity and clay mineral content contribute to the complexity of the fault core’s hydrogeological characteristics, especially its permeability. Seven fault core samples in Renlou coal mine were collected for clay min...
Zeyad, Abdullah M. Almalki, Ali
Published in
Arabian Journal of Geosciences
Worldwide consumption of cement must be reduced because of the serious pollution created from its manufacturing process. This study aims to solve this problem and assess efficiency of quarry dust of volcanic pumice as partial alternative to ordinary Portland cement. Investigations on the area of utilization of by-products from pumice industry with ...
Zhang, Qian Zhang, Fangfang Huang, Chengmin
Published in
Environmental Monitoring and Assessment
The heavy metal pollution level in soils is heavily affected by the soil particle size distribution. However, the heavy metal loss during particle size extraction and the effect of calcite on the heavy metals removal in terms of the particle size are unclear. In this study, the distribution of heavy metals (Cu, Cd, Cr, Co, Ni, Zn, Pb, U, and V) was...
Wu, Hongtao Hu, Jinli Shaaban, Muhammad Xu, Peng Zhao, Jinsong Hu, Ronggui
Published in
Ecological Processes
BackgroundThe size of lime material is vital for the efficiency of ameliorating soil acidity, thereby influencing soil biochemical processes. However, the effects of different sized lime material application on soil organic carbon (SOC) mineralization are yet to be elucidated. Therefore, a 35-day incubation experiment was conducted to determine the...
Yu, Bin Yang, Lingwei Chang, Ming van Asch, Theo W. J.
Published in
Environmental Earth Sciences
In areas with strong earthquakes, the triggering rainfall threshold for debris flow initiation decreased dramatically just after the quake, but will increase gradually during the subsequent raining seasons, until the level before the quake. The channel width and particle size in the source area of debris flows in catchments decreased dramatically d...
