Zahra, Mehdi Durand-Zaleski, Isabelle Górecki, Michal Walleser Autiero, Silke Barnett, Gillian Schüpbach, W. M. Michael
Published in
Health and Quality of Life Outcomes
BackgroundA utility value is a health-related quality of life metric (HRQoL) metric used in a cost-effectiveness analysis. While utilities as outcomes in the treatment of advanced Parkinson’s disease (PD) with deep brain stimulation (DBS) are available, they do not currently exist for PD with early motor complications. The objectives of this study ...
váradi, csaba
Parkinson&rsquo / s disease (PD) is a multi-attribute neurodegenerative disorder combining motor and nonmotor symptoms without well-defined diagnostic clinical markers. The presence of primary motor features (bradykinesia, rest tremor, rigidity and loss of postural reflexes) are the most characteristic signs of PD that are also utilized to identify...
Fu, Xiaoxue Wang, Yu He, Xiaofeng Li, Hongyu Liu, Hong Zhang, Xiangyang
Published in
Lipids in Health and Disease
ObjectivesNumerous studies have reported that lipid metabolic abnormalities may play an important role in the development of Parkinson’s disease (PD), with mixed results. This meta-analysis aims to systematically assess the relationship between serum cholesterol or triglyceride and the PD risk and to further determine the role of dyslipidemia in po...
Melnikova, A. Pozdyshev, D. Barinova, K. Kudryavtseva, S. Muronetz, V. I.
Published in
Biochemistry (Moscow)
AbstractDeterioration of energy metabolism in affected cells is an important feature of synucleinopathies, including Parkinson's disease. Here, we studied the association between α-synuclein accumulation and glycolysis using SH-SY5Y neuroblastoma cell lines stably expressing wild-type α-synuclein or its A53T mutant linked to the autosomal dominant ...
chen, chiung mei lin, chih-hsin yih-ru, wu yen, chien-yu huang, yu-ting lin, jia-lan lin, chung-yin chen, wan-ling chao, chih-ying lee-chen, guey-jen
...
Parkinson&rsquo / s disease (PD) is a neurodegenerative disease characterized by selective dopaminergic (DAergic) neuronal degeneration in the substantia nigra (SN) and proteinaceous &alpha / -synuclein-positive Lewy bodies and Lewy neuritis. As a chemical chaperone to promote protein stability and an autophagy inducer to clear aggregate-prone prot...
Nicastro, Nicolas Garibotto, Valentina Burkhard, Pierre R.
Published in
BMC Neurology
BackgroundNeuropathological data and nuclear medicine imaging show extensive serotonergic impairment in Parkinson’s disease (PD). We undertook a case-controlled analysis of 123I-FP-CIT SPECT images to measure extrastriatal serotonergic transporters (SERT) in PD using the Parkinson’s Progression Markers Initiative (PPMI) cohort.MethodsWe included al...
barata-antunes, sandra teixeira, fábio g. mendes-pinheiro, bárbara domingues, ana v. vilaça-faria, helena marote, ana silva, deolinda sousa, rui a. salgado, antónio j.
Parkinson&rsquo / s disease (PD) is the second most common age-related neurodegenerative disorder. The neurodegeneration leading to incapacitating motor abnormalities mainly occurs in the nigrostriatal pathway due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Several animal models have been developed not only to ...
sim, hyuna lee, joo-eun yoo, hee min cho, sunwha lee, hana baek, aruem kim, jisun seo, hyemyung kweon, mi-na kim, hyung gun
...
The diagnosis of Parkinson&rsquo / s disease (PD) is initiated after the occurrence of motor symptoms, such as resting tremors, rigidity, and bradykinesia. According to previous reports, non-motor symptoms, notably gastrointestinal dysfunction, could potentially be early biomarkers in PD patients as such symptoms occur earlier than motor symptoms. ...
oña, edwin daniel jardón, alberto cuesta-gómez, alicia sánchez-herrera-baeza, patricia cano-de-la-cuerda, roberto balaguer, carlos
In recent decades, gaming technology has been accepted as a feasible method for complementing traditional clinical practice, especially in neurorehabilitation / however, the viability of using 3D Virtual Reality (VR) for the assessment of upper limb motor function has not been fully explored. For that purpose, we developed a VR-based version of the...
dudhipala, narendar gorre, thirupathi
Parkinson&rsquo / s disease (rp) is a progressive neurodegenerative disorder. Ropinirole (RP) is a newer generation dopamine agonist used for the treatment of PD. It is prescribed as oral dosage form. However, limited oral bioavailability and frequent dosing limits the RP usage. The objective of the current investigation was to develop, optimize, e...
