Cornejo, Alberto Caballero, Julio Simirgiotis, Mario Torres, Vanessa Sánchez, Luisa Díaz, Nicolás Guimaraes, Marcela Hernández, Marcos Areche, Carlos Alfaro, Sergio
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Published in
Journal of enzyme inhibition and medicinal chemistry
Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most active, we determined the interaction between α-synucl...
Morassi, Mauro Palmerini, Francesco Nici, Stefania Magni, Eugenio Savelli, Giordano Guerra, Ugo Paolo Chieregato, Matteo Morbelli, Silvia Vogrig, Alberto
Published in
Journal of neurology
Considering the similarities with other pandemics due to respiratory virus infections and subsequent development of neurological disorders (e.g. encephalitis lethargica after the 1918 influenza), there is growing concern about a possible new wave of neurological complications following the worldwide spread of SARS-CoV-2. However, data on COVID-19-r...
Katayama, Takayuki Sawada, Jun Takahashi, Kae Yahara, Osamu Hasebe, Naoyuki
Published in
Alzheimer's Research & Therapy
Background This study examined the usefulness of cerebrospinal fluid (CSF) neuron-specific enolase (NSE) levels as a candidate biomarker of neurodegeneration in Alzheimer’s disease (AD), Parkinson’s disease (PD), PD with dementia (PDD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Methods We performed a systematic search of P...
Chang, Min Cheol Park, Jin-Sung Lee, Byung Joo Park, Donghwi
Published in
Dysphagia
Unlike appendicular motor symptoms, such as bradykinesia and rigidity, in Parkinson's disease (PD), which have already been reported to respond well to deep brain stimulation (DBS), there is limited literature on the effects of DBS on swallowing function in patients with PD. The field lacks consensus as there are conflicting reports among existing ...
Enogieru, Adaze Bijou Haylett, William Hiss, Donavon Ekpo, Okobi
Published in
Metabolic brain disease
Many plant-derived bioactive compounds such as rutin are reportedly effective in attenuating neuronal death in most neurodegenerative disorders. Parkinson's disease (PD) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra of the midbrain, and has previously been modelled in-vitro through the specific neuroto...
Wang, Erlei Jia, Yujing Ya, Yang Xu, Jin Mao, Chengjie Luo, Weifeng Fan, Guohua Jiang, Zhen
Published in
Brain imaging and behavior
Previous voxel-based morphometry (VBM) and cortical thickness (CT) studies on Parkinson's disease (PD) have mainly reported the gray matter size reduction, whereas the shape of cortical surface can also change in PD patients. For the first time, we analyzed sulcal depth (SD) patterns in PD patients by using whole brain region of interest (ROI)-base...
Song, Yulu Gong, Tao Saleh, Muhammad G Mikkelsen, Mark Wang, Guangbin Edden, Richard A E
Published in
Magma (New York, N.Y.)
The dopaminergic pathology of Parkinson's disease (PD) impacts circuits involving GABAergic neurons, especially in the brainstem, where the disease manifests early. The aim of this study is to test the hypothesis that levels of gamma-aminobutyric acid (GABA) in the upper brainstem are reduced in patients with PD compared to healthy controls, using ...
Chromiec, Patryk Andrzej Urbaś, Zofia Kinga Jacko, Martyna Kaczor, Jan Jacek
Published in
Aging and Disease
From year to year, we know more about neurodegeneration and Parkinson’s disease (PD). A positive influence of various types of physical activity is more often described in the context of neuroprotection and prevention as well as the form of rehabilitation in Parkinson’s patients. Moreover, when we look at supplementation, clinical nutrition and die...
Carvalho, Joana Cardoso, Rita Guimarães, Isabel Ferreira, Joaquim J
Published in
Logopedics, phoniatrics, vocology
Speech intelligibility, how well a listener comprehends the speaker's message, is related to the listener' expertise and type of the message conveyed. There is no evidence about speech intelligibility in different groups of healthcare professionals and naïve listeners. This study is the first to understand if there were differences in the speech in...
Zhu, Shuzhen Li, Hualing Xu, Xiaoyan Luo, Yuqi Deng, Bin Guo, Xingfang Guo, Yang Yang, Wucheng Wei, Xiaobo Wang, Qing
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Published in
Aging and Disease
Cardiovascular autonomic dysfunctions (CAD) are prevalent in Parkinson’s disease (PD). It contributes to the development of cognitive dysfunction, falls and even mortality. Significant progress has been achieved in the last decade. However, the underlying mechanisms and effective treatments for CAD have not been established yet. This review aims to...
