Behl, Tapan Kaur, Gagandeep Fratila, Ovidiu Buhas, Camelia Judea-Pusta, Claudia Teodora Negrut, Nicoleta Bustea, Cristiana Bungau, Simona
Published in
Translational Neurodegeneration
Current therapies for Parkinson’s disease (PD) are palliative, of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of neurodegeneration. Due to the complication of such a multifactorial disorder and significant limitations of the therapy, numerous genetic approaches have been proved effective...
Chang, Ta-Chih Chen, Yi-Cun Huang, Yu-Chi Lin, Wei-Che Lu, Cheng-Hsien
Published in
BMC Neurology
BackgroundParkinson’s disease (PD), frequently accompanied by cognitive impairments, is associated with systemic oxidative stress and abnormal structural changes on brain images. We aimed to identify the correlation between systemic oxidative stress and cognitive function in PD patients with different periventricular white matter hyperintensities (...
Underwood, Rachel Gannon, Mary Pathak, Aneesh Kapa, Navya Chandra, Sidhanth Klop, Alyssa Yacoubian, Talene A.
Published in
Acta Neuropathologica Communications
Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies. αSyn is hypothesized to misfold and spread throughout the brain in a prion-like fashion. Transmission of αsyn necessi...
Monteiro Oliveira, Fábio Henrique Fernandes da Cunha, Daniel Gomes Rabelo, Amanda David Luiz, Luiza Maire Fraga Vieira, Marcus Alves Pereira, Adriano de Oliveira Andrade, Adriano
Published in
SN Applied Sciences
Clinical diagnosis of Parkinson’s disease (PD) motor symptoms remains a problem. Most of the current studies focus on objective evaluations to make the evaluation more reliable. Most of these systems are based on the use of inertial and electromyographic sensors that require contact with the body part being assessed. Contact sensors restrict natura...
Baek, Ji-Hoon Nam, Chang Hyun Lee, Su Chan Ahn, Hye Sun Ha, Yong-Chan
Published in
International orthopaedics
The purpose of this study was to compare the functional outcomes, activity levels, mortalities, implant survival rates, and complications of total knee arthroplasty (TKA) of patients with Parkinson's disease (PD) with those of patients in a control group over a minimum ten year follow-up period. From January 2007 to December 2009, 46 TKAs were perf...
Fazekas, Máté Gáspár, Péter Németh, Balázs
Published in
Sensors (Basel, Switzerland)
Localization is a key part of an autonomous system, such as a self-driving car. The main sensor for the task is the GNSS, however its limitations can be eliminated only by integrating other methods, for example wheel odometry, which requires a well-calibrated model. This paper proposes a novel wheel odometry model and its calibration. The parameter...
Xiao, Zhuangzhuang Lei, Tong Liu, Yanyan Yang, Yanjie Bi, Wangyu Du, Hongwu
Published in
Stem Cell Research & Therapy
Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, is caused by the loss of dopaminergic (DAergic) neurons in the substantia nigra resulting in a series of motor or non-motor disorders. Current treatment methods are unable to stop the progression of PD and may bring certain side effects. Cell replacement therapy h...
Tancheva, Lyubka Lazarova, Maria Saso, Luciano Kalfin, Reni Stefanova, Miroslava Uzunova, Diamara Atanasov, Atanas G
Published in
Journal of molecular neuroscience : MN
Previous evidence has shown a link between neurodegenerative diseases, including Parkinson's disease (PD), and melatonin. The data in the literature about the impact of the hormone under different experimental PD conditions are quite controversial, and its effect on memory impairment in the disease is very poorly explored. The current research was ...
Zhang, Dongdong Li, Sheng Hou, Liyan Jing, Lu Ruan, Zhengzheng Peng, Bingjie Zhang, Xiaomeng Hong, Jau-Shyong Zhao, Jie Wang, Qingshan
...
Published in
Journal of Neuroinflammation
BackgroundCognitive decline occurs frequently in Parkinson’s disease (PD), which greatly decreases the quality of life of patients. However, the mechanisms remain to be investigated. Neuroinflammation mediated by overactivated microglia is a common pathological feature in multiple neurological disorders, including PD. This study is designed to expl...
Zhang, Hui Meng, Fanwen Li, Xingyu Ning, Yali Cai, Meng
Published in
BMC Neurology
BackgroundNocturnal symptoms in Parkinson’s disease are often treated after management of daytime manifestations. In order to better understand the unmet needs of nocturnal symptoms management, we analyzed the characteristics and burden of nocturnal symptoms from patients’ perspectives and explored their changes over time. Overall symptoms (occurri...
