KRALJEVSKA, MELANIJA
Parkinson's disease (PD) is a progressive brain disorder which is characterized by movement problems such as tremor, stiffness, slowness of movement and dizziness, as well as non-motor symptoms, which include sleep disorders, constipation, problems concentrating, depression and emotional changes. Due to the clinical heterogeneity of PD, the existen...
García-Ramos, R Santos-García, D Alonso-Cánovas, A Álvarez-Sauco, M Ares, B Ávila, A Caballol, N Carrillo, F Escamilla Sevilla, F Freire, E
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Published in
Neurologia (Barcelona, Spain)
The main challenge of Parkinson's disease in women of childbearing age is managing symptoms and drugs during pregnancy and breastfeeding. The increase in the age at which women are having children makes it likely that these pregnancies will become more common in future. This study aims to define the clinical characteristics of women of childbearing...
Santos-García, D Catalán, M J Puente, V Valldeoriola, F Regidor, I Mir, P Matías-Arbelo, J Parra, J C Grandas, F
Published in
Neurologia (Barcelona, Spain)
To compare the characteristics of patients undergoing treatment with continuous intestinal infusion of levodopa-carbidopa (CIILC) for advanced Parkinson's disease and the data on the effectiveness and safety of CIILC in the different autonomous communities (AC) of Spain. A retrospective, longitudinal, observational study was carried out into 177 pa...
da Luz, Marcella Campos Lima Bezerra, Gleyce Kelly Araújo Asano, Amdore Guescel C Chaves de Lemos, Maria da Conceição Cabral, Poliana Coelho
Published in
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Evaluate the occurrence of sarcopenia and determinant factors in individuals with Parkinson's disease (PD) in a city in northeastern Brazil. Case series with 77 men and women (adults and older adults) with PD. The risk of sarcopenia was determined using the SARC-F and SARC-CalF screening tools. The diagnosis of sarcopenia was based on the new conse...
Afonso, Luis C. S. Pereira, Clayton R. Weber, Silke A. T. Hook, Christian Falcão, Alexandre X. Papa, João P.
Bag-of-Visual Words (BoVW) and deep learning techniques have been widely used in several domains, which include computer-assisted medical diagnoses. In this work, we are interested in developing tools for the automatic identification of Parkinson's disease using machine learning and the concept of BoVW. The proposed approach concerns a hierarchical...
Ammal Kaidery, Navneet Ahuja, Manuj Sharma, Sudarshana M Thomas, Bobby
Published in
Antioxidants & redox signaling
Significance: Advancements in and access to health care have led to unprecedented improvements in the quality of life and increased lifespan of human beings in the past century. However, aging is a significant risk factor for neurodegenerative diseases (NDs). Hence, improved life expectancy has led to an increased incidence of NDs. Despite intense ...
Oda, Wakana Fujita, Yuki Baba, Kousuke Mochizuki, Hideki Niwa, Hitoshi Yamashita, Toshihide
Published in
Cell Death & Disease
Repulsive guidance molecule-a (RGMa), a glycosylphosphatidylinositol-anchored membrane protein, has diverse functions in axon guidance, cell patterning, and cell survival. Inhibition of RGMa attenuates pathological dysfunction in animal models of central nervous system (CNS) diseases including spinal cord injury, multiple sclerosis, and neuromyelit...
Zhu, Shuzhen Deng, Bin Huang, Zifeng Chang, Zihan Li, Hualin Liu, Hui Huang, Yanjun Pan, Ying Wang, Yanping Chao, Yin-Xia
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Published in
NPJ Parkinson's Disease
To evaluate the correlation between “hot cross bun” sign (HCBs) and disease severity in multiple system atrophy (MSA). We recruited patients with probable and possible MSA with parkinsonism (MSA-P) or the cerebellar ataxia (MSA-C) subtypes. Clinical and imaging characteristics were collected and comparison was performed between MSA-C and MSA-P case...
Shen, Ting Yue, Yumei He, Tingting Huang, Cong Qu, Boyi Lv, Wen Lai, Hsin-Yi
Published in
Frontiers in Aging Neuroscience
Patients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology of PD has also been found in the enteric nervous system (ENS). Many studies have reported significant PD-related alterations of gut microbiota. This meta-analysis was performed to evaluate the differe...
Romero-Gutiérrez, Elizabeth Vázquez-Cárdenas, Paola Moreno-Macías, Hortensia Salas-Pacheco, José Tusié-Luna, Teresa Arias-Carrión, Oscar
Published in
NPJ Parkinson's Disease
Parkinson’s disease (PD), a common neurodegenerative disorder, has a complex etiology where environmental and genetic factors intervene. While a number of genes and variants have been identified in recent decades as causative or protective agents of this condition, a limited number of studies have been conducted in mixed populations, such as Mexica...