Gait impairments are well-known in people with Parkinson’s disease (PD). Especially, walking becomes attention demanding when performing a secondary task. Whilst research on dance interventions have recently been found to improve walking in people with PD, there is limited evidence that have objectively assessed the effects of dance on gait with an...
Published in BMC Neuroscience
BackgroundParkinson's disease is a progressive degenerative nervous system disease. Recent studies have shown that secondary changes in the GABA system play directly affect the pathogenesis of PD. There is still much debate about GABA concentrations because currently, GABA concentrations in the brain tissue are obtained indirectly by measuring its ...
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There is a lack of consistent study findings on associations between workplace exposures and the risk of Parkinson disease (PD) and a paucity of such data on women. We assessed PD risk among occupational groups to derive insights about potential occupation-specific exposures in a large cohort of women. The Women's Health Initiative Observational St...
This work proposes an original method for disease subtyping from both longitudinal clinical variables and genetic markers via a mixture of regressions model, with logistic weights function of a potentially large number of genetic variables. In order to address these large-scale problems, variable selection is an essential step. We thus propose to d...
OBJECTIVE: The outer mitochondrial membrane protein Miro1 is a crucial player in mitochondrial dynamics and calcium homeostasis. Recent evidence indicated that Miro1 mediates calcium-induced mitochondrial shape transition (MiST), which is a prerequisite for the initiation of mitophagy. Moreover, altered Miro1 protein levels have emerged as a shared...
Gait impairments are well-known in people with Parkinson’s disease (PD). Parkinson’s gait is characterised by reduced gait speed, stride length, and swing times, and increased stride-to-stride variability. Especially, walking becomes attention demanding when performing a secondary task resulting in a poor gait. Whilst research on dance intervention...
Parkinson’s disease (PD) is a neurodegenerative disorder of the central nervous system which manifests as a broad spectrum of motor and non-motor symptoms. While there is accumulating evidence supporting dance for improving motor features in PD, it is not yet clear if the benefits extend to non-motor features.
Parkinson's disease (PD) is a degenerative disorder of the brain characterized by the impairment of the nigrostriatal system. This impairment leads to specific motor manifestations (i.e., bradykinesia, tremor, and rigidity) that are assessed through clinical examination, scales, and patient-reported outcomes. New sensor-based and wearable technolog...
Magnetic iron oxide nanoparticles, magnetite/maghemite, have been identified in human tissues, including the brain, meninges, heart, liver, and spleen. As these nanoparticles may play a role in the pathogenesis of neurodegenerative diseases, a pilot study explored the occurrence of these particles in the cervical (neck) skin of 10 patients with Par...
