Published in Communications Biology
Heo and Pincet demonstrate the influence of α-synuclein aggregation on in vitro asymmetric membranes using a microfluidic setup. They show that synuclein aggregation on the asymmetric membranes leads to its thinning and formation of pores of discrete sizes and synuclein insertion immobilizes both the leaflets of the asymmetric membrane.
Published in Acta neurologica Belgica
Nocturnal blood pressure (BP) changes are an indicator of autonomic dysfunction. We aim to investigate the correlation between nocturnal blood pressure (BP) variability, vitamin D levels and Parkinson's disease severity (PD) in this study. Thirty-five patients with PD participated in the study. Disease severity was evaluated by United Parkinson's D...
臨床用iPS細胞を用いたパーキンソン病治療の非臨床研究を実施 --ヒトiPS細胞由来のドパミン神経前駆細胞の安全性と有効性を確認--. 京都大学プレスリリース. 2020-07-20. / Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD). The regulatory criteria for the clinical application of these therapies, however, have not been establishe...
Freezing of gait (FOG) is one of the most incapacitating and disconcerting symptom in Parkinson's disease (PD). FOG is the result of neural control disorder and motor impairments, which severely impedes forward locomotion. This paper presents the exploitation of 5G spectrum operating at 4.8 GHz (a potential Chinese frequency band for Internet of Th...
The vast majority of neurodegenerative disease cannot be attributed to genetic causes alone and as a result, there is significant interest in identifying environmental modifiers of disease risk. Epidemiological studies have supported an association between long-term exposure to air pollutants and disease risk. Here, we investigate the mechanisms by...
Closed-loop control strategies for deep brain stimulation (DBS) in Parkinson's disease offer the potential to provide more effective control of patient symptoms and fewer side effects than continuous stimulation, while reducing battery consumption. Most of the closed-loop methods proposed and tested to-date rely on controller parameters, such as co...
Published in Human brain mapping
The dopaminergic system has a unique gating function in the initiation and execution of movements. When the interhemispheric imbalance of dopamine inherent to the healthy brain is disrupted, as in Parkinson's disease (PD), compensatory mechanisms act to stave off behavioral changes. It has been proposed that two such compensatory mechanisms may be ...
Published in Nature
Neurons generated in situ in a mouse model of Parkinson's disease.
Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from the discoveries made in familial and/or sporadic forms of PD in the Caucasian population. The transferability and the clinical utility of genetic discoveries to other ethnically diverse populations are unknown. The Indian population has been under-represe...
Parkinsonova bolezen (PB) je pogosta nevrodegenerativna bolezen možganov, pri kateri pride do zmanjšanja količine nevromelanina (NM) v substanci nigri (SN). Številne magnetnoresonančne (MR) študije so z uporabo T1-obteženih sekvenc dokazale zmanjšano površino in prostornino SN pri bolnikih s PB ter znižano intenziteto signala SN. Motorični simptomi...
